Research press release


Nature Medicine

Imaging responses to anti-angiogenic cancer therapy


核磁気共鳴画像化法(MRI)を用いた脳組織の画像化では、組織内灌流、血液量、血管径に関する情報が得られる。Kyrre Emblemたちは、血管の構造や血流量、組織酸素飽和度といった血管の機能に関する情報が得られるVAI技術を開発した。これらの情報は、現在の非侵襲的画像化技術では簡単には評価できない。コンピューター・シミュレーションを利用して、Emblemたちは、VAIによって見つかった血管のループが、特定の血管構造を示すことを明らかにした。またEmblemたちは、再発性多形神経膠芽腫患者30人について、血管新生阻害剤セジラニブ(血管形成のカギとなるタンパク質受容体を阻害する)投与の前後で後ろ向き解析を行って、この方法の臨床での評価も行った。


Vessel architectural imaging (VAI) can be used in patients with glioblastoma-a type of brain tumor-to show improved microcirculation and tissue oxygenation in response to anti-angiogenic therapies. This technique, reported this week in Nature Medicine, can be used to identify those patients who respond to such therapies, as it allows for non-invasive observation of drug effects in tumor blood vessels and the surrounding tissue, which correlates to patient survival.

Imaging brain tissue using magnetic resonance imaging (MRI) provides information about tissue perfusion, blood volume and vessel caliber. Kyrre Emblem and colleagues develop the VAI technique that provides information about vessel anatomy and function, such as blood flow and tissue oxygen saturation, which cannot be easily assessed with current non-invasive imaging techniques. Using computational simulations, the authors show that vessels loops identified with VAI indicate a particular vessel architecture. They also validate the approach in the clinic using a retrospective analysis of 30 patients with recurrent glioblastoma multiforme before and after treatment with the angiogenic inhibitor cediranib, which inhibits a key protein receptor for vasculature growth.

The authors found that reduced vessel calibers correlated with improved microcirculation and oxygen saturation in patients who responded to anti-angiogenic therapy and who ultimately survived longer. They could identify a larger group of responding patients using the VAI approach, suggesting this technique may be a more sensitive biomarker than traditional MRI biomarkers for angiogenic inhibitor efficacy, in part probably because of the sensitivity of VAI to changes in oxygen saturation levels.

doi: 10.1038/nm.3289


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