Research press release


Nature Medicine

Arthritis is spreading


関節リウマチは数カ所の関節から始まって、その後ほとんどの関節へと広がるが、この進行の原因となる経路はこれまで解明されていなかった。Elena Neumannたちは、滑膜繊維芽細胞(関節を浸している関節液中に存在する細胞で、関節炎患者の軟骨破壊にかかわっている)が、炎症を広める働きをするかを検証した。


A mechanism that accounts for the spreading of arthritis between joints is presented in a study published online in this week's Nature Medicine.

Rheumatoid arthritis starts in a few joints but subsequently spreads to affect most joints, though the pathways that account for this progression were previously unknown. Elena Neumann and her colleagues tested whether synovial fibroblasts ― cells present in the fluid that bathes the joints and also implicated in cartilage destruction in arthritis patients ― could spread the disease.

Using mice, the scientists implanted healthy human cartilage plus synovial fibroblasts from arthritis patients into one side of their bodies, and healthy cartilage without the fibroblasts into the opposite side. Synovial fibroblasts actively moved from one side to the other via blood vessels, leading to marked cartilage destruction.

doi: 10.1038/nm.2050


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