Research press release


Nature Medicine

A transplantable bioengineered kidney



Harald Ottたちは、ラット、ブタ、ヒトの死体腎から細胞成分を取り除き、腎臓の完全な構造を保ち、体液の濾過、分泌、再吸収に重要な老廃物回収系、尿管をもつ腎臓骨格を作製した。ラットの腎臓骨格にラットの腎細胞と血管細胞とを混ぜて戻した後、臓器再生用バイオリアクターで組織を増殖させたところ、この再生腎臓では尿が生成した。この生体工学による人工腎臓は排泄機能ももち、ラットに移植後も、出血や血栓形成の兆候は見られなかった。

A bioengineered kidney that shows renal function and produces urine both outside of a body and after transplantation in a rat, is reported online this week in Nature Medicine. Although the functional studies have only been shown in rats, the findings suggest a promising approach for bioengineering kidneys using patient-derived cells to circumvent rejection.

Even though hemodialysis-the use of a machine to filter wastes and fluids from the body-has increased survival of individuals with advanced kidney disease, organ transplantation remains the only curable treatment. However, there are not sufficient donor kidneys and a considerable number of transplant rejections or even post-operative deaths still occur.

Harald Ott and his colleagues remove the cellular components of cadaveric rat, porcine and human kidneys to create renal scaffolds that hold intact renal structures, waste collecting system and ureters, which are important for filtration, secretion and reabsorption of body liquids. After adding back a combination of rat kidney and blood vessel cells to a rat renal scaffold, the authors grew the tissue in a whole-organ bioreactor; the regenerated kidneys produce urine. These bioengineered kidneys also have excretory function without signs of bleeding or clot formation after transplantation in rats.

doi: 10.1038/nm.3154


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