Research press release


Nature Medicine

Farm dust microbes linked with reduced asthma in city children



 P Kirjavainenたちは、フィンランドの小児395人の田舎もしくは郊外にある住居の屋内ダストの微生物相を調べ、微生物存在量のパターンに農家と関連して見られるはっきりした特徴があることを見いだした。さらに、ドイツの小児1031人からなるコホートについての調査でも同様の知見が得られ、農家ではないが、屋内微生物相がフィンランドの農家の微生物相とよく似た家に住む子どもでは、喘息の発症リスクが低下していることが明らかになった。


Exposure to a farm-like house dust microbiome may be associated with reduced asthma development in children living in urban environments, reports a study published online this week in Nature Medicine.

The development of asthma has been linked with urbanization, which may involve the loss of critical house dust microbial species that are still present on farms. However, it has been unclear whether farm bacteria are also associated with reduced asthma prevalence when they are present in urban environments.

Pirkka Kirjavainen and colleagues studied indoor dust microbiota from the rural and suburban homes of 395 Finnish children and identified a distinct microbial abundance pattern associated with farm homes. They then replicated these findings in a cohort of 1,031 German children, showing a reduced risk of asthma in children living in non-farm homes with an indoor microbiota similar to that of Finnish farm homes.

Although this observational study could not conclusively establish that individual microbial species were directly responsible for protection against asthma, it provides further support for the role of environment-derived bacteria in asthma development. The authors suggest that measuring the composition of household microbiota may be useful for assessing and monitoring the relative risk of children developing asthma in suburban and urban homes.

doi: 10.1038/s41591-019-0469-4


メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週各ジャーナルからの最新の「注目のハイライト」をまとめて皆様にお届けいたします。