Research press release


Nature Aging

Ageing: Mutations in the ageing human heart identified

ヒトの心臓において加齢とともに蓄積する体細胞変異が特定されたことを報告する論文が、Nature Aging に掲載される。この知見は、心臓の機能が年齢とともにどのように低下するかを理解する上で役立つ可能性がある。


今回、Christopher Walshたちの研究グループは、単一細胞の全ゲノム塩基配列解読を行って、0.4〜82歳の12人の心筋細胞における体細胞一塩基変異(DNA塩基配列中の1つの塩基が変異したもの)のプロファイリングを行った。その結果、心筋細胞に酸化的DNA損傷、DNA修復機構の不全と塩基置換の増加を示す変異シグネチャーがあることが明らかになった。これらは、全て加齢とともに蓄積する。


The somatic mutations that accumulate in the human heart with age are identified in a paper in Nature Aging. The findings may help us to understand how the function of the heart declines with age.

The DNA of cells that make up the human body, including the heart, accumulate errors — or somatic mutations — as we age. Although some somatic mutations appear to have little effect, others, for example, underlie the development of cancer or are likely to contribute to physiological ageing. The accumulation of somatic mutations in heart muscle cells may contribute to a decline in cellular function. However, researchers are yet to obtain data concerning these mutations.

Christopher Walsh and colleagues profile somatic single-nucleotide variants — whereby a single nucleotide in the DNA sequence is mutated — in human heart muscle cells from 12 individuals aged between 0.4 and 82 years old, using single-cell whole-genome sequencing. The authors reveal that heart muscle cells show mutational signatures that are indicative of oxidative DNA damage and failed DNA repair mechanisms, as well as an increase in base substitutions — all of which accumulate with age.

Further research will be needed to determine whether the identified processes have a causal role in heart ageing and how they may impair heart function.

doi: 10.1038/s43587-022-00261-5


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