Research press release


Nature Neuroscience

Non-neuronal cells regulate feeding behavior


レプチンはホルモンであって、体内の脂肪細胞から放出され、摂食行動と代謝を調節するとされている。Tamas Horvathたちは、摂食行動と代謝を調節するとされる脳の部位(視床下部)に存在するグリア細胞(膠細胞)の一種、アストロサイト(星状膠細胞)がレプチン受容体を含むことを示した。



The satiety hormone leptin can act on non-neuronal cells in the brain and affect feeding behavior in mice, reports a study published online in Nature Neuroscience.

Leptin is a hormone released by fat cells in the body and is known to regulate feeding behavior and metabolism. Tamas Horvath and colleagues showed that astrocytes-a type of glial cell-in a part of the brain known to regulate feeding and metabolism, the hypothalamus, contain leptin receptors.

Deletion of the gene that encodes leptin receptors, from astrocytes, altered their shape, as well as changing the number of synapses formed by neurons in the hypothalamus. Leptin normally suppresses feeding, but in mice, with no astrocytic leptin receptors, its effects were lessened. Since hypothalamic neurons are known to control feeding behavior, changes in their connectivity brought about by deletion of astrocytic leptin receptors might underlie the resulting changes in feeding behavior.

This study is the first to show that leptin acts on astrocytes, in addition to its effects on neurons, adding another dimension to how the brain and its various cell types regulate feeding behavior.

doi: 10.1038/nn.3725

「Nature 関連誌注目のハイライト」は、ネイチャー広報部門が報道関係者向けに作成したリリースを翻訳したものです。より正確かつ詳細な情報が必要な場合には、必ず原著論文をご覧ください。

メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週最新のNature 関連誌のハイライトを皆様にお届けいたします。