Research press release


Nature Genetics

Hookworm genome sequenced



今回、Makedonka Mitrevaたちは、ヒト鉤虫の一種であるアメリカ鉤虫のゲノムの塩基配列解読を行い、ヒト宿主の感染とヒト宿主との相互作用、そして、吸血と生育に関与する遺伝子の特徴を明らかにし、この知見を利用して、薬物標的と新たな治療介入の候補に優先順位をつけた。また、タンパク質マイクロアレイを用いて、感染者の血液のスクリーニングを行い、抗鉤虫免疫応答の標的候補となる抗原を同定した。

The draft genome sequence of the hookworm, the most common soil-transmitted parasitic worm, which can infect humans and other animals, is reported in Nature Genetics.

Soil transmitted parasitic worms, called helminths, are a major cause of neglected tropical diseases (NTDs), affecting an estimated 1-2 billion individuals worldwide. These parasitic worms are transmitted through contaminated soil and live in the intestines of their animal host. An estimated 700 million individuals worldwide are infected with hookworm, causing a range of possible symptoms including clinical anaemia, malnutrition during pregnancy, as well as impaired cognitive and/or physical development in children.

Makedonka Mitreva and colleagues sequenced the genome of the human hookworm Necator americanus. They characterize genes involved in infection of and interaction with the human host, blood feeding and development, and use this to prioritize candidate genes for drug targets and new interventions. They also use a protein microarray to screen blood of infected individuals and identify antigens that are potential targets of anti-hookworm immune responses.

doi: 10.1038/ng.2875


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