Research press release


Nature Genetics

New genes associated with intelligence and neuroticism found


Danielle Posthumaたちの研究グループは、25万人以上についての遺伝的データと知能の測定値を解析した。その結果、ゲノム上の知能に関連する207の座位(うち190が新規)、および知能に関連する特異的な1016の遺伝子(うち939が新規)が見つかった。Posthumaたちは、今回の解析結果に基づいて、知能が高い場合にアルツハイマー病とADHDに対する防御効果が認められるという考えを示している。また、Posthumaたちは、神経系の発達とシナプス構造に関連する遺伝的経路も同定した。



Hundreds of new genetic loci associated with intelligence and neuroticism have been identified, substantially broadening understanding of cognitive function, report two papers published online this week in Nature Genetics.

Danielle Posthuma and colleagues analysed the genetic data and measurements of intelligence of more than 250,000 individuals. They find 190 new genomic loci and 1,016 specific genes - of which 939 are new - that are associated with intelligence. Based on their analysis, the authors suggest that increased intelligence may protect against both Alzheimer’s disease and ADHD. They also identify genetic pathways relating to nervous system development and synaptic structure.

In another study, the same authors focus on neuroticism, which is an important risk factor for depression and schizophrenia. Analysing almost half a million individuals, they identify over 500 genes associated with neuroticism. The authors describe two distinct genetic subclusters of neuroticism, one relating to depressed affect and the other to worry.

Together, these studies provide new insights into the neurobiology and genetics of cognition. The authors suggest that these datasets may aid future research into neuropsychiatric diseases.

doi: 10.1038/s41588-018-0152-6


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