Research press release


Nature Communications

Biotechnology: Contact lens measures pressure and delivers glaucoma drug

ワイヤレスで眼圧を感知し、必要なときに抗緑内障薬を送達するコンタクトレンズについて報告する論文が、Nature Communications に掲載される。このコンタクトレンズは、柔軟性があり、電池を必要とせず、コンパクトな設計で、有望な緑内障治療システムとなる可能性を秘めている。


今回、Xi Xie、Cheng Yangたちは、電気センサーを用いて眼圧を測定し、必要に応じて薬物を投与できるセラノスティック・コンタクトレンズを開発した。このコンタクトレンズは、ブタとウサギの眼で検証され、眼圧の変化を検出できることが確認された。また、眼圧の測定値がハイリスクのレベルに達すると、薬物送達モジュール(ワイヤレス給電で駆動する)が、抗緑内障薬を角膜のバリアを通過して眼の前房へと送達する。


A contact lens capable of wireless intraocular pressure sensing and on-demand anti-glaucoma drug delivery, is reported in Nature Communications. The device is flexible and battery-free, with a compact design, and may be a promising system for the treatment of glaucoma.

Glaucoma (and its associated diseases) can cause irreversible vision loss, with damage often caused by an increase of intraocular pressure due to the abnormal circulation of fluid within the eye. This pressure can vary with human activities and circadian rhythm, which makes treatment challenging as it requires the long-term and continuous tracking of the eye’s condition. Theranostic devices — which combine therapeutics and diagnostics — are capable of monitoring a determined condition and applying an appropriate treatment.

Xi Xie, Cheng Yang and colleagues developed a theranostic contact lens, which uses electrical sensing to measure intraocular pressure and can deliver a drug on demand. The device was tested in porcine and rabbit eyes and was able to detect changes in intraocular pressure. When the measured intraocular pressure reaches a high-risk level, the drug delivery module (powered by wireless power transfer) has the ability to trigger delivery of an anti-glaucoma drug into the anterior chamber of the eye across corneal barriers.

The authors suggest that fabrication of the device is compatible with existing large-scale and cost-effective manufacturing processes. However, they indicate that further research is needed before it can move towards clinical tests.

doi: 10.1038/s41467-022-29860-x


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