Research Abstract



Regenerative capacity in newts is not altered by repeated regeneration and ageing

2011年7月12日 Nature Communications 2 : 384 doi: 10.1038/ncomms1389


江口 吾朗1*,江口 幸子1**,中村 研太2,Manisha C. Yadav3,José Luis Millán3 & Panagiotis A. Tsonis2

  1. 自然科学研究機構 基礎生物学研究所
  2. デイトン大学(米国)
  3. サンフォード・バーナム医学研究所(米国)
    *(現所属)学校法人 尚絅学園
The extent to which adult newts retain regenerative capability remains one of the greatest unanswered questions in the regeneration field. Here we report a long-term lens regeneration project spanning 16 years that was undertaken to address this question. Over that time, the lens was removed 18 times from the same animals, and by the time of the last tissue collection, specimens were at least 30 years old. Regenerated lens tissues number 18 and number 17, from the last and the second to the last extraction, respectively, were analysed structurally and in terms of gene expression. Both exhibited structural properties identical to lenses from younger animals that had never experienced lens regeneration. Expression of mRNAs encoding key lens structural proteins or transcription factors was very similar to that of controls. Thus, contrary to the belief that regeneration becomes less efficient with time or repetition, repeated regeneration, even at old age, does not alter newt regenerative capacity.