Research press release


Scientific Reports

Medical research: Electrical stimulation helps control bleeding in rats



今回、Daniel Palanker 研究室に所属するYossi Mandelたちは、ラットの大腿部(鼠径部)と腹腔の動脈と静脈にマイクロ秒の電流パルスを印加した。その結果、これらの血管が数秒以内に収縮し、それから数分以内に血管が元の大きさに拡張した。そして、電流を強くしたところ、血管が完全かつ永続的に遮断された。ラットの大腿動脈と腹部動脈の出血速度は低下し、出血が急速に止まり、大腿動脈からの出血量は、処置をしない場合の7分の1に減った。また、組織の損傷は、この血管収縮から最長3時間半後まで観察されなかったが、組織に対する長期影響の可能性を評価するには、これよりも長期間の追跡調査が必要となる。

Electrical stimulation of the veins and arteries of rats, using microsecond pulses, may be able to help control bleeding and reduce haemorrhage in non-compressible wounds, a study published in Scientific Reports suggests. Further research is needed to establish whether the technique would be effective in human patients, but the technique might potentially be helpful for controlling non-compressible haemorrhages in traumatic injury or during surgery.

Applying a tourniquet to a haemorrhage can help to reduce traumatic mortality on the battlefield, but the technique cannot be used on non-compressible haemorrhages, including bleeding into body cavities, such as the abdomen, and wounds in the junction between the trunk and the limbs or neck. In the 1970s, it was shown that applying a direct electric current to a clamped blood vessel for several minutes could induce thrombosis. However, the resulting thermal damage prevented the use of the technology in clinical practice.

Yossi Mandel and colleagues from Daniel Palanker’s lab, applied microsecond pulses of electric current to the veins and arteries in the femoral (groin) area and abdominal cavities of rats. This induced vasoconstriction in these blood vessels within seconds, with the blood vessels dilating back to their original size within a few minutes. With a stronger current complete and permanent blocking of the blood vessels occurred. The bleeding rate in the rats’ femoral and abdominal arteries decreased, rapidly stopping the haemorrhage, and reducing the blood loss from the femoral artery by a factor of seven compared to untreated animals. The authors observed no damage to the tissue up to 3.5 hours after the vasoconstriction, although a longer follow-up is needed to evaluate any potential longer term effects on the tissue.

doi: 10.1038/srep02111


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