Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation

2015年10月29日 npj Aging 1, Article number:15009 (2015) doi:10.1038/npjamd.2015.9




Atsushi Nakagomi, Sho Okada, Masataka Yokoyama, Yohko Yoshida, Ippei Shimizu, Takashi Miki, Yoshio Kobayashi & Tohru Minamino

Obesity: A sex-specific appetite signal
A signaling pathway that inhibits appetite in the brain plays an opposite role in fat tissue, with a particularly strong effect in females. Within the brain, the interaction between brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) promotes weight loss and reduced eating. Researchers led by Tohru Minamino at Niigata University in Japan have demonstrated that these proteins exhibit a different activity in fat. Whereas mice lacking BDNF or TrkB in the brain were prone to overeating and obesity, these traits were absent when this pathway was disrupted in fat. Intriguingly, female mice lacking TrkB in their fat cells proved less prone to obesity when fed a high-fat diet, while little change was seen in males. This may result from interactions with estrogen signaling, and the researchers see a potential target for treating female obesity.


npj Aging and Mechanisms of Disease EISSN: 2056-3973(online)