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遗传学: 杀手是怎样炼成的
Genetics: Evolution of a killer
7月1日

气候科学: 湿地既能生成甲烷、又能消耗甲烷
Climate science: Methane is created and destroyed in wetlands
7月1日

微生物学: 生命早期的抗生素使用可能会影响发育
Microbiology: Early-life antibiotic use may affect development
7月1日

衰老: 恢复雄性果蝇的性欲
Ageing: Restoring male flies' mojo
7月1日
 
  最新论文 阅读原文(英语)  
 
利用金星凌日探测行星上层大气 OPEN
Fabio Reale, Angelo F. Gambino, Giuseppina Micela, Antonio Maggio, Thomas Widemann and Giuseppe Piccioni
The atmosphere of a transiting planet shields the stellar radiation enabling size and density stratification to be estimated. Here, the authors study Venus and show that the measured radius depends on the wavelength used, which has implications for Venus’s ionosphere and may help in planning future missions.
23 June 2015 | doi: 10.1038/ncomms8563
Earth Sciences  Atmospheric science  Geology and geophysics 

在过去一百万年位于高轨道倾角时与地球类似的含水泥石流曾活跃于火星 OPEN
T. de Haas, E. Hauber, S. J. Conway, H. van Steijn, A. Johnsson and M. G. Kleinhans
It is thought that water flowed on the surface of Mars in the geological past during periods of high orbital obliquity. Here, the authors assess how much liquid water was present and suggest that debris flows occurred at Earth-like frequencies during high-obliquity periods in the past million years.
23 June 2015 | doi: 10.1038/ncomms8543
Earth Sciences  Geology and geophysics 

一个可能的未来大规模太阳活动极小期对区域性气候的影响 OPEN
Sarah Ineson, Amanda C. Maycock, Lesley J. Gray, Adam A. Scaife, Nick J. Dunstone, Jerald W. Harder, Jeff R. Knight, Mike Lockwood, James C. Manners and Richard A. Wood
Regional surface climate response to a future decline in solar activity remains uncertain. Here, via numerical simulations, the authors show that a return to Maunder Minimum-like lows by 2050 could lead to some areas of significantly reduced surface warming via modulation of the North Atlantic Oscillation.
23 June 2015 | doi: 10.1038/ncomms8535
Earth Sciences  Atmospheric science  Climate science 

灵芝可通过调节肠道微生物群构成以减少小鼠肥胖 OPEN
Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young and Hsin-Chih Lai
Ganoderma lucidum is a medicinal mushroom used in Traditional Chinese Medicine with putative anti-diabetic properties. Here, the authors show that polysaccharides from a water extract of this mushroom exert beneficial metabolic effects by modulating the composition of the gut microbiota in mice.
23 June 2015 | doi: 10.1038/ncomms8489
Biological Sciences  Medical research  Microbiology 

证据表明哮喘是一种受母亲饮食和细菌代谢物影响的发育性起源疾病
Alison N. Thorburn, Craig I. McKenzie, Sj Shen, Dragana Stanley, Laurence Macia, Linda J. Mason, Laura K. Roberts, Connie H. Y. Wong, Raymond Shim, Remy Robert, Nina Chevalier, Jian K. Tan, Eliana Mariño, Rob J. Moore, Lee Wong, Malcolm J. McConville, Dedreia L. Tull, Lisa G. Wood, Vanessa E. Murphy, Joerg Mattes et al.
Growing evidence suggests that environmental rather than genetic factors are major contributors to asthma development. Here the authors show that high intake of dietary fibre by pregnant mice increases resistance of their progeny to the development of allergic airways disease.
23 June 2015 | doi: 10.1038/ncomms8320
Biological Sciences  Immunology 

一种代谢应激诱导的miR-34a-HNF4α通路调节脂质和脂蛋白代谢
Yang Xu, Munaf Zalzala, Jiesi Xu, Yuanyuan Li, Liya Yin and Yanqiao Zhang
The nuclear hormone receptor HNF4α is important for liver function. Here, Xu et al. show that miR-34a regulates expression of HNF4α and is increased under conditions of metabolic stress, suggesting miR-34a promotes the development of non-alcoholic fatty liver disease.
23 June 2015 | doi: 10.1038/ncomms8466
Biological Sciences  Medical research 

水通道蛋白3调节的过氧化氢传输是牛皮癣的发展和角质细胞中的NF-κB信号所必需的
Mariko Hara-Chikuma, Hiroki Satooka, Sachiko Watanabe, Tetsuya Honda, Yoshiki Miyachi, Takeshi Watanabe and A. S. Verkman
Aquaporin-3 (AQP3) mediates cellular uptake of water and hydrogen peroxide (H2O2). Here, the authors show that TNF-induced H2O2 enters keratinocytes via AQP3, eliciting NF-κB activation and the development of psoriasis, and identify AQP3 as a potential therapeutic target for this inflammatory immune-mediated disease.
23 June 2015 | doi: 10.1038/ncomms8454
Biological Sciences  Cell biology  Medical research 

通过嵌段共聚物纳米网格的任意晶格对称性 OPEN
Pawel W. Majewski, Atikur Rahman, Charles T. Black and Kevin G. Yager
Nanoscale patterning methods based on self-assembly promise to revolutionize the fabrication of high-tech devices, but suffer from a limited number of possible lattice symmetries. Here, the authors use a laser zone annealing technique to pattern block copolymers into any 2D mesh motif they desire.
23 June 2015 | doi: 10.1038/ncomms8448
Physical Sciences  Materials science  Nanotechnology 

一种全息超导体的普适将远离平衡态动力学
Julian Sonner, Adolfo del Campo and Wojciech H. Zurek
In strongly coupled systems lacking long-lived quasiparticles, conventional methods are inadequate to study the dynamics of phase transitions. Here, the authors use holographic duality to investigate the superconducting transition and show that critical dynamics and formation of topological defects are universal.
23 June 2015 | doi: 10.1038/ncomms8406
Physical Sciences  Condensed matter  Theoretical physics 

具有反馈回路的生化信号转导中的麦克斯韦尔的恶魔(Maxwell’s demon) OPEN
Sosuke Ito and Takahiro Sagawa
The connection between information and thermodynamics is embodied in the figure of Maxwell’s demon, a feedback controller. Here, the authors apply thermodynamics of information to signal transduction in chemotaxis of E. coli, predicting that its robustness is quantified by transfer entropy.
23 June 2015 | doi: 10.1038/ncomms8498
Physical Sciences  Theoretical physics 

百里香水解酶为CD8+ T细胞的阳性选择产生的独特缩氨酸基序 OPEN
Katsuhiro Sasaki, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama and Shigeo Murata
Proteasomes digest intracellular proteins into peptides that are then presented to lymphocytes as antigens. Here the authors show that a thymic epithelium-specific proteasome subunit cuts model proteins in a pattern favouring their weak binding to T cell receptor, and thus T cell positive selection.
23 June 2015 | doi: 10.1038/ncomms8484
Biological Sciences  Immunology 

在原子水平中揭示二维异质结构的平面化学特征 OPEN
Harry Chou, Ariel Ismach, Rudresh Ghosh, Rodney S. Ruoff and Andrei Dolocan
The properties of 2D materials such as graphene can vary according to the quality and, for vertical devices, the interfaces between materials. Here, the authors report a method using TOF-SIMS, micro-Raman spectroscopy and atomic force microscopy to give high levels of detail of vertical 2D heterostructures.
23 June 2015 | doi: 10.1038/ncomms8482
Chemical Sciences  Materials science  Nanotechnology 

Zic1通过调节视黄酸生产和传输控制基板前体非细胞自主形成
Maria Belen Jaurena, Hugo Juraver-Geslin, Arun Devotta and Jean-Pierre Saint-Jeannet
Cranial placode progenitors arise from a common precursor field known as the preplacodal region. Here the authors show that transcription factor Zic1 induces the localized production and transport of retinoic acid at the anterior neural plate, which in turn activates a placode developmental programme in neighbouring cells.
23 June 2015 | doi: 10.1038/ncomms8476
Biological Sciences  Developmental biology 

利用超快显微镜在钙钛矿薄膜中实现远程电荷传输的空间和时间成像 OPEN
Zhi Guo, Joseph S. Manser, Yan Wan, Prashant V. Kamat and Libai Huang
Determining the mechanism of charge carrier transport in solar cells is important for their development towards higher efficiencies. Here, the authors elucidate the spatial and temporal diffusion of charge carriers in hybrid perovskite thin films through ultrafast transient absorption microscopy.
23 June 2015 | doi: 10.1038/ncomms8471
Physical Sciences  Applied physics  Materials science  Optical physics 

研究铁橄榄石在普通和碳质球粒陨石母体上录得的早期水活动
Patricia M. Doyle, Kaori Jogo, Kazuhide Nagashima, Alexander N. Krot, Shigeru Wakita, Fred J. Ciesla and Ian D. Hutcheon
The parent bodies of many chondritic meteorites experienced aqueous alteration, the chronology of which helps constrain their histories. Here, the authors synthesize a fayalite standard and report reliable ages of secondary fayalite, from which model accretion ages are determined and the place of accretion is inferred.
23 June 2015 | doi: 10.1038/ncomms8444
Earth Sciences  Geology and geophysics  Planetary sciences 

一种蚊子脂氧素/蛋白复合物在冈比亚按蚊(Anopheles gambiae)中介导先天免疫启动效应 OPEN
Jose Luis Ramirez, Giselle de Almeida Oliveira, Eric Calvo, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Jose M. Ribeiro and Carolina Barillas-Mury
A soluble factor induced by Plasmodium infection promotes hemocyte differentiation and increases mosquitoe resistance to subsequent infections. Here the authors show that this factor consists of a Lipocalin/Lipoxin A4 complex, and that insects can metabolize arachidonic acid to produce lipoxins.
23 June 2015 | doi: 10.1038/ncomms8403
Biological Sciences  Immunology  Molecular biology 

PI3K-C2γ是一种Rab5效应物能够有选择地控制胰岛素信号下游溶酶体Akt2的活化 OPEN
Laura Braccini, Elisa Ciraolo, Carlo C. Campa, Alessia Perino, Dario L. Longo, Gianpaolo Tibolla, Marco Pregnolato, Yanyan Cao, Beatrice Tassone, Federico Damilano, Muriel Laffargue, Enzo Calautti, Marco Falasca, Giuseppe D. Norata, Jonathan M. Backer and Emilio Hirsch
The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2.
23 June 2015 | doi: 10.1038/ncomms8400
Biological Sciences  Cell biology  Medical research 

单层半导体叠片中层间取向依赖的光吸收与发射 OPEN
Hoseok Heo, Ji Ho Sung, Soonyoung Cha, Bo-Gyu Jang, Joo-Youn Kim, Gangtae Jin, Donghun Lee, Ji-Hoon Ahn, Myoung-Jae Lee, Ji Hoon Shim, Hyunyong Choi and Moon-Ho Jo
Single atomic layers of transition metal dichalcogenides have outstanding electrical and optical properties. Here, the authors show that light absorption and emission from stacks of different transition metal dichalcogenide monolayers can be tuned by rotating the crystals.
23 June 2015 | doi: 10.1038/ncomms8372
Physical Sciences  Materials science  Optical physics 

胶体元表面在红外波段显示接近理想和可调谐的光吸收 OPEN
Matthew J. Rozin, David A. Rosen, Tyler J. Dill and Andrea R. Tao
Metasurfaces are arrays of subwavelength structures that are tailored to produce specific optical responses. Rozin et al. show that large-area metasurfaces can be readily fabricated by self-assembly of colloidal nanocrystals of different geometries, producing tunable reflectance and absorbance properties.
23 June 2015 | doi: 10.1038/ncomms8325
Physical Sciences  Materials science  Nanotechnology  Optical physics 

高质量的夹黑磷异质结构及其量子振荡 OPEN
Xiaolong Chen, Yingying Wu, Zefei Wu, Yu Han, Shuigang Xu, Lin Wang, Weiguang Ye, Tianyi Han, Yuheng He, Yuan Cai and Ning Wang
Black phosphorus is an atomically thin material that exhibits excellent properties for electronics applications, but these degrade in atmospheric conditions. Here, the authors demonstrate the fabrication of stable, ultra-clean and high-mobility black phosphorus sandwiched between the layers of boron nitride.
23 June 2015 | doi: 10.1038/ncomms8315
Physical Sciences  Materials science  Nanotechnology 

探索自熵测量的强相关性二维等离子体
A. Y. Kuntsevich, Y. V. Tupikov, V. M. Pudalov and I. S. Burmistrov
Electrons trapped to a two-dimensional plane can exhibit many exotic properties. Here, the authors use a technique that measures entropy per electron to explore the evolution of such a system from the Fermi liquid regime to a previously unexplored regime of a strongly correlated charged plasma.
23 June 2015 | doi: 10.1038/ncomms8298

细菌微管蛋白FtsZ需要其内在无序的链接器指挥强壮的细胞壁结构
Kousik Sundararajan, Amanda Miguel, Samantha M. Desmarais, Elizabeth L. Meier, Kerwyn Casey Huang and Erin D. Goley
The bacterial division protein FtsZ recruits cell wall synthesis enzymes to the cytokinetic ring. Sundararajan et al. show that FtsZ deletion variants alter peptidoglycan structure without detectable effects on enzyme recruitment, suggesting an additional role in the regulation of cell wall metabolism.
23 June 2015 | doi: 10.1038/ncomms8281
Biological Sciences  Biochemistry  Microbiology 

双官能团非贵金属氧化物纳米粒子电催化剂通过锂诱导转换实现整体水解离 OPEN
Haotian Wang, Hyun-Wook Lee, Yong Deng, Zhiyi Lu, Po-Chun Hsu, Yayuan Liu, Dingchang Lin and Yi Cui
There is intensive research underway in developing electrocatalysts for water splitting. Here, the authors present a lithium-induced conversion reaction method to develop an active and stable bifunctional catalyst for overall water splitting, outperforming the combination of noble metal catalysts.
23 June 2015 | doi: 10.1038/ncomms8261
Chemical Sciences  Catalysis  Materials science  Nanotechnology 

线索响应腹侧纹状体神经元中眶额叶病变消除信号传输的生物学意义
Nisha K. Cooch, Thomas A. Stalnaker, Heather M. Wied, Sheena Bali-Chaudhary, Michael A. McDannald, Tzu-Lan Liu and Geoffrey Schoenbaum
The ventral striatum (VS) has long been proposed as crucial for integrating biologically significant associative information to drive actions. Here, the authors demonstrate that orbitofrontal cortical inputs to the VS play a critical role in biasing activity to represent reward value.
23 June 2015 | doi: 10.1038/ncomms8195
Biological Sciences  Neuroscience 

用人工制造的随机光场控制小颗粒间的分散力 OPEN
Georges Brügger, Luis S. Froufe-Pérez, Frank Scheffold and Juan José Sáenz
Natural dispersion forces acting between molecules and particles arise from electromagnetic fields generated by quantum and thermal fluctuations. Here, Brügger et al. show that isotropic dispersion forces between colloidal particles can be induced, controlled and tuned with artificial, fluctuating laser light fields.
22 June 2015 | doi: 10.1038/ncomms8460
Physical Sciences  Condensed matter  Optical physics  Physical chemistry 

整数量子霍尔作用机制(hall effect regime)中强劲的电子配对
H K. Choi, I. Sivan, A. Rosenblatt, M. Heiblum, V. Umansky and D. Mahalu
Electron pairing is a rare phenomenon which can result in exotic behaviour such as superconductivity. Here, the authors evidence robust electron pairing in the quantum Hall edge states of a Fabry–Perot interferometer via Aharonov–Bohm conductance oscillations and quantum shot noise measurements.
22 June 2015 | doi: 10.1038/ncomms8435
Physical Sciences  Applied physics  Condensed matter 

量子kagome冰中发现一个二维自旋液体
Juan Carrasquilla, Zhihao Hao and Roger G. Melko
Two-dimensional quantum spin liquid states, which retain spin disorder down to low temperatures, have never been realized experimentally. Here, the authors use quantum Monte Carlo methods to predict a new route to this state in rare-earth pyrochlore quantum spin ices under an applied (111) magnetic field.
22 June 2015 | doi: 10.1038/ncomms8421
Physical Sciences  Theoretical physics 

在植物生长素信号输送过程中肽基脯氨酰异构化以水稻Aux/IAAs为目标实现蛋白酶体降解
Hongwei Jing, Xiaolu Yang, Jian Zhang, Xuehui Liu, Huakun Zheng, Guojun Dong, Jinqiang Nian, Jian Feng, Bin Xia, Qian Qian, Jiayang Li and Jianru Zuo
Auxin signalling requires the degradation of Aux/IAA transcriptional repressors which is mediated by their interaction with F-box proteins. Jing et al. show that in rice, OsIAA11 interaction with the F-box protein TIR1 is enhanced by cyclophilin-dependent cis/trans isomerisation of the repressor.
22 June 2015 | doi: 10.1038/ncomms8395
Biological Sciences  Cell biology  Plant sciences 

在人类体细胞中一种piRNA样小RNA相互作用并调节p-ERM蛋白质 OPEN
Yuping Mei, Yuyan Wang, Priti Kumari, Amol Carl Shetty, David Clark, Tyler Gable, Alexander D. MacKerell, Mark Z. Ma, David J. Weber, Austin J. Yang, Martin J. Edelman and Li Mao
PIWI-interacting RNAs (piRNAs) suppress transposon and gene expression during development. Here, the authors identify many piRNAs and piRNA-like small RNAs in 11 human cell lines, and show that one piRNA-like small RNA binds to phosphorylated ERM proteins to regulate cancer cell migration and invasion.
22 June 2015 | doi: 10.1038/ncomms8316
Biological Sciences  Cell biology  Molecular biology 

癌症相关ASXL1突变可作为ASXL1-BAP1复合体的功能获得性突变 OPEN
Anand Balasubramani, Antti Larjo, Jed A. Bassein, Xing Chang, Ryan B. Hastie, Susan M. Togher, Harri Lähdesmäki and Anjana Rao
Premature truncations of ASXL1, a subunit of a deubiquitinase complex, are frequent in myeloid leukemia. Here, the authors show that expression of truncated ASXL1 in a haematopoietic precursor cell line enhances the deubiquitinase activity and leads to differentiation to the mast cell lineage.
22 June 2015 | doi: 10.1038/ncomms8307
Biological Sciences  Cancer  Molecular biology 

DNA聚合酶γ的核酸外切酶活性是线粒体DNA复制过程中的连接反应所必须的 OPEN
Bertil Macao, Jay P. Uhler, Triinu Siibak, Xuefeng Zhu, Yonghong Shi, Wenwen Sheng, Monica Olsson, James B. Stewart, Claes M. Gustafsson and Maria Falkenberg
Mitochondrial DNA (mtDNA) polymerase γ has a 3′–5′ exonuclease proofreading activity. Here, the authors show it is required for creating ligatable ends during mtDNA replication, and inactivation of the activity in mice causes strand-specific nicks in DNA and the formation of linear mtDNA fragments.
22 June 2015 | doi: 10.1038/ncomms8303
Biological Sciences  Cell biology  Molecular biology 

一个引发酶亚基是利用一个古细菌真核类型引发酶的高效引物合成所必需的
Bing Liu, Songying Ouyang, Kira S. Makarova, Qiu Xia, Yanping Zhu, Zhimeng Li, Li Guo, Eugene V. Koonin, Zhi-Jie Liu and Li Huang
Archaea encode an eukaryotic-type primase comprising a catalytic subunit PriS and a noncatalytic subunit PriL. Here, the authors identify in an archaeon Sulfolobus solfataricus an essential noncatalytic subunit of primase, PriX, that forms PriSLX trimer and increases the efficiency of primer synthesis.
22 June 2015 | doi: 10.1038/ncomms8300
Biological Sciences  Biochemistry  Molecular biology 

TRIM29调节DNA修复蛋白到受损核染色质中的组装
Yasushi Masuda, Hidehisa Takahashi, Shigeo Sato, Chieri Tomomori-Sato, Anita Saraf, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan W. Conaway and Shigetsugu Hatakeyama
Many proteins are assembled into damaged chromatins to repair DNA double-strand breaks (DSBs). Here, the authors show that TRIM29 binds to modified histone H3 and H4 tails following DSB formation and functions as a scaffold protein to assemble DNA repair proteins into chromatin.
22 June 2015 | doi: 10.1038/ncomms8299
Biological Sciences  Cell biology  Molecular biology 

硅纳米线中使用石墨烯隧道壁垒的自旋传输和汉勒效应(Hanle effect)
O. M. J. van ’t Erve, A. L. Friedman, C. H. Li, J. T. Robinson, J. Connell, L. J. Lauhon and B. T. Jonker
Graphene forms low-resistance tunnel barriers for spin injection from a ferromagnet into silicon. Here, the authors fabricate silicon nanowire non-local spin valves with graphene tunnel barriers, evidencing spin accumulation and transport via Hanle spin precession measurements.
19 June 2015 | doi: 10.1038/ncomms8541
Physical Sciences  Applied physics  Condensed matter  Nanotechnology 

胶体辊轴群中的意外旋涡 OPEN
Antoine Bricard, Jean-Baptiste Caussin, Debasish Das, Charles Savoie, Vijayakumar Chikkadi, Kyohei Shitara, Oleksandr Chepizhko, Fernando Peruani, David Saintillan and Denis Bartolo
Confined populations of interacting motile particles often display collective motion in the form of large-scale vortices, such as fish groups and bacteria colonies. Bricard et al. study a model system with self-propelled colloidal rollers and identify the constituents responsible for emergent vortices.
19 June 2015 | doi: 10.1038/ncomms8470
Physical Sciences  Applied physics  Fluids and plasma physics  Materials science 

探索具有宏观谐波振荡器的变形换向器 OPEN
Mateusz Bawaj, Ciro Biancofiore, Michele Bonaldi, Federica Bonfigli, Antonio Borrielli, Giovanni Di Giuseppe, Lorenzo Marconi, Francesco Marino, Riccardo Natali, Antonio Pontin, Giovanni A. Prodi, Enrico Serra, David Vitali and Francesco Marin
A minimal observable length leading to deformed commutation relations is a common feature of theories that aim to merge quantum physics and gravity. Here, the authors analyse the free evolution of micro- and nano-oscillators to lower the limits on the parameters quantifying commutator deformation.
19 June 2015 | doi: 10.1038/ncomms8503
Physical Sciences  Applied physics  Theoretical physics 

随尺寸变化的化学感觉极限 OPEN
Brendan A. Bicknell, Peter Dayan and Geoffrey J. Goodhill
Theoretical studies on chemosensation often invoke a model of three dimensional unbounded diffusion, but many biological problems involve two-dimensional diffusion in a bounded domain. Here Bicknell et al. present a model for chemosensation that covers bounded domains of any dimension, and apply it to biological problems in two dimensions.
19 June 2015 | doi: 10.1038/ncomms8468
Biological Sciences  Biophysics 

应变变形二硫化钼中的人造原子光电晶体 OPEN
Hong Li, Alex W. Contryman, Xiaofeng Qian, Sina Moeini Ardakani, Yongji Gong, Xingli Wang, Jeffery M. Weisse, Chi Hwan Lee, Jiheng Zhao, Pulickel M. Ajayan, Ju Li, Hari C. Manoharan and Xiaolin Zheng
Periodically strained monolayer molybdenum disulphide funnels photogenerated electron-hole pairs across an electric field induced by a spatially graded band gap, mimicking a crystal of artificial atoms. Here, the authors experimentally demonstrate the artificial crystal in strain-textured molybdenum disulphide.
19 June 2015 | doi: 10.1038/ncomms8381
Physical Sciences  Materials science  Nanotechnology 

层状钼联硒化物中伴随结构转换缺乏的由压力诱发的金属化 OPEN
Zhao Zhao, Haijun Zhang, Hongtao Yuan, Shibing Wang, Yu Lin, Qiaoshi Zeng, Gang Xu, Zhenxian Liu, G. K. Solanki, K. D. Patel, Yi Cui, Harold Y. Hwang and Wendy L. Mao
Controlling the properties of transition metal chalcogenides enables the study of new condensed-matter phenomena and the development of potential applications. Here, the authors continuously tune the crystal and electronic structure of molybdenum diselenide away from the pristine state using pressure.
19 June 2015 | doi: 10.1038/ncomms8312
Physical Sciences  Condensed matter  Materials science 

由合成范德瓦尔斯异质结构制造的原子薄共振隧道二极管 OPEN
Yu-Chuan Lin, Ram Krishna Ghosh, Rafik Addou, Ning Lu, Sarah M. Eichfeld, Hui Zhu, Ming-Yang Li, Xin Peng, Moon J. Kim, Lain-Jong Li, Robert M. Wallace, Suman Datta and Joshua A. Robinson
The family of two-dimensional materials is ever growing, but greater functionality can be realized by combining them together. Here, the authors report the direct synthesis of multijunction heterostructures made from graphene, tungsten diselenide and either molybdenum disulphide or molybdenum diselenide.
19 June 2015 | doi: 10.1038/ncomms8311
Physical Sciences  Applied physics  Materials science 

中心纺锤体蛋白与PRC1之间的直接互动增强了中心纺锤体的机械韧性 OPEN
Kian-Yong Lee, Behrooz Esmaeili, Ben Zealley and Masanori Mishima
The central spindle is an anti parallel bundle of microtubules that forms between segregating chromosomes and links the two halves of the mitotic spindle. Lee et al. reveal that interaction between two microtubule bundling proteins at the central spindle confers robustness to cortical pulling forces.
19 June 2015 | doi: 10.1038/ncomms8290
Biological Sciences  Biophysics  Cell biology 

经由大气压等离子体的电子溶剂化 OPEN
Paul Rumbach, David M. Bartels, R. Mohan Sankaran and David B. Go
Free, or solvated, electrons in a solution are known to form at the interface between a liquid and a gas. Here, the authors use absorption spectroscopy in a total internal reflection geometry to probe solvated electrons generated at a plasma in contact with the surface of an aqueous solution
19 June 2015 | doi: 10.1038/ncomms8248
Physical Sciences  Fluids and plasma physics  Physical chemistry 

晶体在玻璃表面上的光诱导爬行 OPEN
Emi Uchida, Reiko Azumi and Yasuo Norikane
Creating the motion of nanosized or microsized objects is essential for building robots at small scales. Here, Uchida et al. move photoresponsive organic crystals on a glass substrate using two lamps, which crystallize and melt the crystal front and the rear, respectively, to generate the moving force.
18 June 2015 | doi: 10.1038/ncomms8310
Physical Sciences  Materials science  Nanotechnology 

外来体交付的小RNA调节针对内毒素的炎症反应 OPEN
Margaret Alexander, Ruozhen Hu, Marah C. Runtsch, Dominique A. Kagele, Timothy L. Mosbruger, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward and Ryan M. O’Connell
Response to inflammatory stimuli such as endotoxin is coordinated at many levels. Here, the authors show that two microRNAs known to regulate inflammatory response inside the cell are secreted by dendritic cells and modulate inflammatory signalling in the neighbouring cells.
18 June 2015 | doi: 10.1038/ncomms8321
Biological Sciences  Immunology 

难溶性有机物在海洋中的低效微生物生产
Helena Osterholz, Jutta Niggemann, Helge-Ansgar Giebel, Meinhard Simon and Thorsten Dittmar
The extent to which the microbial carbon pump contributes to the generation of marine refractory dissolved organic matter (RDOM) remains a matter of debate. Here, the authors report results from a 3-year mesocosm study, and show that most of the microbial DOM is different from RDOM in the ocean.
18 June 2015 | doi: 10.1038/ncomms8422
Earth Sciences  Biogeochemistry  Microbiology  Oceanography 

多价控制HP1α具有沉默染色质状态的关联动力学 OPEN
Sinan Kilic, Andreas L. Bachmann, Louise C. Bryan and Beat Fierz
Chromatin effector proteins often employ multivalent interactions with histone post-translational modifications. Here by using chemically defined nucleosome array and single-molecule microscopy, the authors show that effector multivalency prolongs chromatin retention and accelerates the association rate.
18 June 2015 | doi: 10.1038/ncomms8313
Biological Sciences  Biochemistry  Molecular biology 

一个化学基因组筛选发现CK2可作为PTEN缺失肿瘤中促衰老治疗的目标
Madhuri Kalathur, Alberto Toso, Jingjing Chen, Ajinkya Revandkar, Claudia Danzer-Baltzer, Ilaria Guccini, Abdullah Alajati, Manuela Sarti, Sandra Pinton, Lara Brambilla, Diletta Di Mitri, Giuseppina Carbone, R Garcia-Escudero, Alessandro Padova, Letizia Magnoni, Alessia Tarditi, Laura Maccari, Federico Malusa, Ravi Kiran Reddy Kalathur, Lorenzo A. Pinna et al.
It has been proposed that the identification of genes regulating senescence in the absence of PTEN might help develop pro-senescence compounds for the treatment of cancer. Here, the authors use a combination of chemical and shRNA functional screen and identify CK2 as a potential target.
18 June 2015 | doi: 10.1038/ncomms8227
Biological Sciences  Cancer  Cell biology  Molecular biology 

熊田-格氏型(Kumada–Grignard-type)联芳联轴器遇水反应 OPEN
Anish Bhattacharjya, Piyatida Klumphu and Bruce H. Lipshutz
Organomagnesium reagents have been a staple for carbon–carbon bond formations for over a century, but are notoriously sensitive to water. Here, the authors show a Kumada-type coupling of aryl halides on water, with a potential intermediary of an in situ formed Grignard reagent.
18 June 2015 | doi: 10.1038/ncomms8401
Chemical Sciences  Catalysis  Organic chemistry 

醇类百万分率加载的有机催化对映选择性甲硅烷基化 OPEN
Sang Yeon Park, Ji-Woong Lee and Choong Eui Song
Organocatalytic methods typically do not approach the extremely low loadings that can be achieved with some metal catalysed processes. Here, the authors report a remarkably powerful organocatalyst capable of performing asymmetric silylations with sub parts-per-million level loadings.
18 June 2015 | doi: 10.1038/ncomms8512
Chemical Sciences  Catalysis  Organic chemistry 
 

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