《自然》 目录

Volume 553 Number 7688

Editorials

News

News Features

News & Views

Mice learn to avoid the rat race p.284

Mice can learn to overcome their naturally aggressive approach to conflict resolution, instead adopting a cooperative strategy. This discovery provides a simple animal model in which to investigate a complex social behaviour.

doi: 10.1038/d41586-017-08835-9

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Pathogens boosted by food additive p.285

Epidemic strains of the bacterium Clostridium difficile have now been found to grow on unusually low levels of the food additive trehalose, providing a possible explanation for C. difficile outbreaks since 2001.

doi: 10.1038/d41586-017-08775-4

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Strategy for making safer opioids bolstered p.286

Compounds have been made that activate only the G-protein signalling pathway when bound to the μ-opioid receptor — the target of opioid pain relievers. These compounds lack one of the main side effects of currently used opioids.

doi: 10.1038/d41586-018-00045-1

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Homing in on a key factor of climate change p.288

The sensitivity of Earth’s climate to atmospheric carbon dioxide levels is a big unknown in predicting future global warming. A compelling analysis suggests that we can rule out high estimates of this sensitivity.

doi: 10.1038/d41586-018-00480-0

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Limitless translation limits translation p.289

Evidence has now been found that ribosomes — the cell’s translational apparatus — can pass beyond the main protein-coding region of messenger RNAs to form ‘traffic jams’ that inhibit protein expression.

doi: 10.1038/d41586-017-08785-2

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Articles

Dietary trehalose enhances virulence of epidemic Clostridium difficile p.291

Two hypervirulent ribotypes of the enteric pathogen Clostridium difficile, RT027 and RT078, have independently acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose, suggesting a correlation between the emergence of these ribotypes and the widespread adoption of trehalose in the human diet.

J. Collins, C. Robinson, H. Danhof, C. W. Knetsch, H. C. van Leeuwen, T. D. Lawley, J. M. Auchtung & R. A. Britton

doi: 10.1038/nature25178

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Molecular mechanism of promoter opening by RNA polymerase III p.295

Cryo-EM structures of Pol III preinitiation complexes are presented, comprising Pol III and the transcription factor TFIIIB bound to a natural promoter in different functional states.

Matthias K. Vorländer, Heena Khatter, Rene Wetzel, Wim J. H. Hagen & Christoph W. Müller

doi: 10.1038/nature25440

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Structural basis of RNA polymerase III transcription initiation p.301

Detailed structures of yeast RNA polymerase III and its initiation complex shed light on how the transcription of essential non-coding RNAs begins and allow comparisons with other RNA polymerases.

Guillermo Abascal-Palacios, Ewan Phillip Ramsay, Fabienne Beuron, Edward Morris & Alessandro Vannini

doi: 10.1038/nature25441

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Letters

Black-hole-regulated star formation in massive galaxies p.307

The star formation histories of galaxies, as encapsulated in their integrated optical spectra, depend on the mass of the black holes present at their centres.

Ignacio Martín-Navarro, Jean P. Brodie, Aaron J. Romanowsky, Tomás Ruiz-Lara & Glenn van de Ven

doi: 10.1038/nature24999

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Large granulation cells on the surface of the giant star π1 Gruis p.310

Interferometric images of the surface of the giant star π1 Gruis reveal few but large convective cells, consistent with existing models of stellar surface convection.

C. Paladini, F. Baron, A. Jorissen, J.-B. Le Bouquin, B. Freytag, S. Van Eck, M. Wittkowski, J. Hron, A. Chiavassa, J.-P. Berger + et al.

doi: 10.1038/nature25001

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A global map of travel time to cities to assess inequalities in accessibility in 2015 p.333

Travel time to cities in 2015 is quantified in a high-resolution global map that will be useful for socio-economic policy design and conservation research.

D. J. Weiss, A. Nelson, H. S. Gibson, W. Temperley, S. Peedell, A. Lieber, M. Hancher, E. Poyart, S. Belchior, N. Fullman + et al.

doi: 10.1038/nature25181

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Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus p.337

In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death.

Romain Gibeaux, Rachael Acker, Maiko Kitaoka, Georgios Georgiou, Ila van Kruijsbergen, Breanna Ford, Edward M. Marcotte, Daniel K. Nomura, Taejoon Kwon, Gert Jan C. Veenstra + et al.

doi: 10.1038/nature25188

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An extracellular network of Arabidopsis leucine-rich repeat receptor kinases p.342

A high-throughput assay is used to analyse 40,000 potential extracellular domain interactions of a large family of plant cell surface receptors (LRR-RKs) and provide a cell surface interaction network for these receptors.

Elwira Smakowska-Luzan, G. Adam Mott, Katarzyna Parys, Martin Stegmann, Timothy C Howton, Mehdi Layeghifard, Jana Neuhold, Anita Lehner, Jixiang Kong, Karin Grünwald + et al.

doi: 10.1038/nature25184

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AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation p.356

A regulatory mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1.

Martina M. Yordanova, Gary Loughran, Alexander V. Zhdanov, Marco Mariotti, Stephen J. Kiniry, Patrick B. F. O’Connor, Dmitry E. Andreev, Ioanna Tzani, Paul Saffert, Audrey M. Michel + et al.

doi: 10.1038/nature25174

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