Tracking nanodiamond-tagged stem cells
Nature Nanotechnology
2013년8월5일
A method that is used to track the fate of a single stem cell within mouse lung tissue is reported in a study published online this week in Nature Nanotechnology. The method may offer insights into the factors that determine the acceptance of transplanted stem cells, and their ability to regenerate within a host.
Stem cell therapy has the potential to repair and regenerate damaged tissues. Implanted cells might, however, be rejected, migrate or die; tracking stem cells in vivo may help to further understand what happens once these cells are inside the host.
Huan-Cheng Chang and colleagues used fluorescent nanodiamonds to tag lung stem cells and implant them in mice with damaged lungs. They found that not only did the damaged lung cells of the mice restore rapidly, but that the uptake and regeneration of stem cells could be tracked with single-cell resolution. The authors suggest that, in the future, the technique could also be used to monitor the uptake of different kinds of stem cell, such as bone marrow stem cells.
doi: 10.1038/nnano.2013.147
리서치 하이라이트
-
7월29일
Engineering: Just add water to activate a disposable paper batteryScientific Reports
-
7월26일
Physics: Slab avalanche origin similar to that of earthquakesNature Physics
-
7월13일
Planetary science: Origins of one of the oldest martian meteorites identifiedNature Communications
-
7월12일
Astronomy: Casualty risk from uncontrolled rocket re-entries assessedNature Astronomy
-
7월12일
Physics: Beam vibrations used to measure ‘big G’Nature Physics
-
7월6일
Biotechnology: Mice cloned from freeze-dried somatic cellsNature Communications