Imaging: Zooming in on a beating heart
Nature Communications
2012년9월12일
A microscope that can take high-resolution images of a beating mouse heart over a period of several hours is reported in Nature Communications this week. The microscopic setup, which combines a motion stabilizer with an algorithm for gated image acquisition, could facilitate in vivo imaging of other organs, if adapted accordingly.
Modern microscopes can take images at high resolution and at high speed but they usually require imaged objects to remain fairly static. This poses a particular challenge for imaging in animals, were cardiac and respiratory motion causes image defects. Claudio Vinegoni and collaborators designed a ring-shaped motion stabilizer that is attached to the heart of anaesthetised mice. Motion defects were further reduced by using only bits of images taken at specific times during the heart and respiratory cycle. The final images were then reconstructed on a computer in real time. The researchers used this microscope to image white blood cells migrating through coronary vessels and towards inflamed areas of the heart in a mouse model of myocardial infarction.
doi: 10.1038/ncomms2060
리서치 하이라이트
-
7월29일
Engineering: Just add water to activate a disposable paper batteryScientific Reports
-
7월26일
Physics: Slab avalanche origin similar to that of earthquakesNature Physics
-
7월13일
Planetary science: Origins of one of the oldest martian meteorites identifiedNature Communications
-
7월12일
Astronomy: Casualty risk from uncontrolled rocket re-entries assessedNature Astronomy
-
7월12일
Physics: Beam vibrations used to measure ‘big G’Nature Physics
-
7월6일
Biotechnology: Mice cloned from freeze-dried somatic cellsNature Communications