Immunostimulatory nanoparticles for cancer therapy
Nature Materials
2012년7월17일
Nanoparticle gels that deliver an immunostimulatory molecule and an inhibitor of an immunosuppressive factor to tumours over a period of a few days are reported online this week in Nature Materials. When injected in melanoma tumours in mice, the nanoparticles facilitate sustained delivery of the molecules, delay tumour growth and significantly increase the survival time of the mice.
One of the mechanisms by which aggressive cancers such as melanomas evade the immune system is by the secretion, from tumours, of immunosuppressive factors such as TGF-beta. This protein inhibits the effects of Interleukin-2 (IL-2) - a signalling molecule used in conventional immunotherapy that mediates immune responses. Tarek Fahmy and colleagues designed a nanoparticle consisting of a protective lipid bilayer surrounding a degradable polymer gel encapsulating a lipid-soluble TGF-beta inhibitor and the water-soluble IL-2 immunostimulatory protein. The researchers show that the nanoparticles enhance the activity of innate and adaptive immune responses against subcutaneous and metastatic melanomas in tumour-bearing mice.
doi: 10.1038/nmat3355
리서치 하이라이트
-
7월29일
Engineering: Just add water to activate a disposable paper batteryScientific Reports
-
7월26일
Physics: Slab avalanche origin similar to that of earthquakesNature Physics
-
7월13일
Planetary science: Origins of one of the oldest martian meteorites identifiedNature Communications
-
7월12일
Astronomy: Casualty risk from uncontrolled rocket re-entries assessedNature Astronomy
-
7월12일
Physics: Beam vibrations used to measure ‘big G’Nature Physics
-
7월6일
Biotechnology: Mice cloned from freeze-dried somatic cellsNature Communications