Clean energy can fuel the future — and make the world healthier p.245

Research challenges the myth that clean energy acts as a brake on global economic development.

doi: 10.1038/d41586-023-02510-y

GDP at 70: why genuinely sustainable development means settling a debate at the heart of economics p.246

Researchers advocating reform of the world’s main measure of growth have an opportunity to participate in the process that sets the rules.

doi: 10.1038/d41586-023-02509-5

Ancient DNA reveals the living descendants of enslaved people through 23andMe p.251

A landmark genomic study raises the possibility that many more people could find links to distant ancestors through genetic analysis.

doi: 10.1038/d41586-023-02478-9

Claimed superconductor LK-99 is an online sensation — but replication efforts fall short p.253

Social media is abuzz with chatter about the material, but some scientists are pushing back on the hype.

doi: 10.1038/d41586-023-02481-0

Barbie and body image: a scholar’s take on the research — and the blockbuster film p.254

doi: 10.1038/d41586-023-02433-8

Threatened Mexican oasis loses its main researcher and protector — will it survive? p.255

Valeria Souza has long fought the drainage of the Cuatro Ciénegas basin, where ancient microbes offer clues to the origins of life.

doi: 10.1038/d41586-023-02413-y

Alzheimer’s drug trials plagued by lack of racial diversity p.256

Under-representation of people of colour sparks concerns over the safety and efficacy of drugs in diverse populations.

doi: 10.1038/d41586-023-02464-1

ChatGPT-like AIs are coming to major science search engines p.258

The Scopus, Dimensions and Web of Science databases are introducing conversational AI search.

doi: 10.1038/d41586-023-02470-3

Rules to keep AI in check: nations carve different paths for tech regulation p.260

doi: 10.1038/d41586-023-02491-y

How a controversial US drug policy could be harming cancer patients worldwide p.264

doi: 10.1038/d41586-023-02492-x

Past climate unravels the eastern African paradox p.279

Analyses of sediment from a lake in eastern Africa reveal the relationship between temperature and moisture over the past 75,000 years, and hint at why climate-model projections in the Horn of Africa are at odds with modern trends.

doi: 10.1038/d41586-023-02297-y

How the cGAS–STING system links inflammation and cognitive decline p.280

When DNA is misplaced inside cells, the cGAS–STING molecular system triggers inflammation. It emerges that stimulation of this mechanism in microglial cells of the brain during ageing contributes to cognitive decline.

doi: 10.1038/d41586-023-02240-1

Shaped to roll along a programmed periodic path p.282

An algorithm has been developed for constructing a 3D shape that follows an infinitely repeating path as it rolls under gravity. The approach could have applications in quantum computing and medical imaging.

doi: 10.1038/d41586-023-02335-9

Turning cooperative bacteria into probiotics for human health p.283

Understanding how our gut bacteria combine forces to co-exist and produce beneficial molecules will be crucial for developing next-generation probiotics. Key progress towards achieving this goal has been made.

doi: 10.1038/d41586-023-02407-w

Double-headed molecule activates cell-death pathways in cancer cells p.285

Molecules have been developed that switch a transcription factor from being a repressor of gene expression to an activator — and thereby able to kill cancer cells. The findings offer a fresh strategy for designing anticancer drugs.

doi: 10.1038/d41586-023-02213-4

A cool runaway greenhouse without surface magma ocean p.287

doi: 10.1038/s41586-023-06258-3

A broadband thermal emission spectrum of the ultra-hot Jupiter WASP-18b p.292

doi: 10.1038/s41586-023-06230-1

Sustained wet–dry cycling on early Mars p.299

doi: 10.1038/s41586-023-06220-3

Martian dunes indicative of wind regime shift in line with end of ice age p.303

doi: 10.1038/s41586-023-06206-1

Solid-body trajectoids shaped to roll along desired pathways p.310

doi: 10.1038/s41586-023-06306-y

Frequency–angular resolving LiDAR using chip-scale acousto-optic beam steering p.316

doi: 10.1038/s41586-023-06201-6

Oriented nucleation in formamidinium perovskite for photovoltaics p.323

doi: 10.1038/s41586-023-06208-z

Homomeric chains of intermolecular bonds scaffold octahedral germanium perovskites p.328

doi: 10.1038/s41586-023-06209-y

Reversed Holocene temperature–moisture relationship in the Horn of Africa p.336

doi: 10.1038/s41586-023-06272-5

Rift-induced disruption of cratonic keels drives kimberlite volcanism p.344

doi: 10.1038/s41586-023-06193-3

Global hotspots of traded phylogenetic and functional diversity p.351

doi: 10.1038/s41586-023-06371-3

Early contact between late farming and pastoralist societies in southeastern Europe p.358

doi: 10.1038/s41586-023-06334-8

A cell-type-specific error-correction signal in the posterior parietal cortex p.366

doi: 10.1038/s41586-023-06357-1

cGAS–STING drives ageing-related inflammation and neurodegeneration p.374

doi: 10.1038/s41586-023-06373-1

Synergy and oxygen adaptation for development of next-generation probiotics p.381

doi: 10.1038/s41586-023-06378-w

Sub-1.4 cm³ capsule for detecting labile inflammatory biomarkers in situ p.386

doi: 10.1038/s41586-023-06369-x

Therapy-induced APOBEC3A drives evolution of persistent cancer cells p.393

doi: 10.1038/s41586-023-06303-1

Pharmacological targeting of netrin-1 inhibits EMT in cancer p.402

doi: 10.1038/s41586-023-06372-2

Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer p.409

doi: 10.1038/s41586-023-06367-z

Rewiring cancer drivers to activate apoptosis p.417

doi: 10.1038/s41586-023-06348-2

RNA polymerase II associates with active genes during DNA replication p.426

doi: 10.1038/s41586-023-06341-9

Mega-scale experimental analysis of protein folding stability in biology and design p.434

doi: 10.1038/s41586-023-06328-6

Structure of an endogenous mycobacterial MCE lipid transporter p.445

doi: 10.1038/s41586-023-06366-0