The gene-therapy revolution risks stalling if we don’t talk about drug pricing p.629

Regulation and new intellectual property laws are needed to reduce the cost of gene-editing treatments and fulfil their promise to improve human health.

doi: 10.1038/d41586-023-01389-z

How Rosalind Franklin was let down by DNA’s dysfunctional team p.630

The story of how the structure of DNA was found is one of team science from which one member was unforgivably excluded.

doi: 10.1038/d41586-023-01390-6

SpaceX Starship: launch of biggest-ever rocket ends with explosion p.635

The SpaceX rocket made it partially through its first full test. It could change astrophysics and astronomy, as well as ferry people to the Moon and Mars.

doi: 10.1038/d41586-023-01377-3

How a rural school teacher became a top COVID sleuth p.636

A self-taught Indiana man is among a cadre of community scientists who scour the SARS-CoV-2 genome for problematic mutations.

doi: 10.1038/d41586-023-01047-4

Massive mosquito factory in Brazil aims to halt dengue p.637

Facility will produce up to five billion bacteria-infected mosquitoes per year.

doi: 10.1038/d41586-023-01266-9

White House to tap cancer leader Monica Bertagnolli as new NIH director p.638

Long-awaited decision comes more than a year after Francis Collins resigned as director of the largest public funder of biomedical research in the world.

doi: 10.1038/d41586-023-01378-2

AI science search engines are exploding in number — are they any good? p.639

Several search tools claim to help researchers do science.

doi: 10.1038/d41586-023-01273-w

Racial inequalities deepened in US prisons during COVID p.640

The proportion of incarcerated people who were Black or Latino increased during the pandemic, mainly because of sentencing differences.

doi: 10.1038/d41586-023-01311-7

Editors quit top neuroscience journal to protest against open-access charges p.641

Members of the departing editorial teams say that the fees to publish articles are unsustainable.

doi: 10.1038/d41586-023-01391-5

Science strengthened banks — but how long will stability last? p.642

doi: 10.1038/d41586-023-01291-8

Rewilding the planet p.644

doi: 10.1038/d41586-023-01370-w

Are repeat COVID infections dangerous? What the science says p.650

doi: 10.1038/d41586-023-01371-9

Mixed plastics upcycled dynamically p.663

Waste plastics contain immiscible polymers, making recycling challenging. A new additive enables the thermal reprocessing of mixed plastics into recyclable, high-performance materials.

doi: 10.1038/d41586-023-01352-y

Extrachromosomal DNA appears before cancer forms p.664

A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation.

doi: 10.1038/d41586-023-00982-6

Yo-yoing stem cells defy dogma to maintain hair colour p.666

The observation that melanocyte stem cells migrate up and down the hair follicle, differentiating into melanocytes and then returning to a stem-cell identity, calls into question long-held assumptions about adult stem cells.

doi: 10.1038/d41586-023-00918-0

Human–AI team halves cost of designing step in microchip fabrication p.667

Engineers and algorithms have competed in a virtual test to design a step in the process of manufacturing computer chips. Pairing human expertise with computational efficiency proves most cost-effective, but only when the timing is right.

doi: 10.1038/d41586-023-01353-x

When influenza viruses don’t play well with others p.668

Influenza viruses that infect the same host can interfere with each other’s replication. This behaviour seems to result in spatial structuring of infected groups of cells in tissue, with implications for viral evolution.

doi: 10.1038/d41586-023-00983-5

Learning the metabolic language of cancer p.670

The conversion of dietary sugar to the molecule lactate is a hallmark of many cancers. The discovery of a new binding partner of lactate provides insight into how cells link nutrient metabolism to the decision to divide.

doi: 10.1038/d41586-023-01024-x

Computational approaches streamlining drug discovery p.673

doi: 10.1038/s41586-023-05905-z

A ring-like accretion structure in M87 connecting its black hole and jet p.686

doi: 10.1038/s41586-023-05843-w

Continuous symmetry breaking in a two-dimensional Rydberg array p.691

doi: 10.1038/s41586-023-05859-2

Build-up and dephasing of Floquet–Bloch bands on subcycle timescales p.696

doi: 10.1038/s41586-023-05850-x

Tracing attosecond electron emission from a nanometric metal tip p.702

doi: 10.1038/s41586-023-05839-6

Human–machine collaboration for improving semiconductor process development p.707

doi: 10.1038/s41586-023-05773-7

Self-powered perovskite photon-counting detectors p.712

doi: 10.1038/s41586-023-05847-6

pH-dependent water permeability switching and its memory in MoS₂ membranes p.719

doi: 10.1038/s41586-023-05849-4

Controlled growth of perovskite layers with volatile alkylammonium chlorides p.724

doi: 10.1038/s41586-023-05825-y

Dynamic crosslinking compatibilizes immiscible mixed plastics p.731

doi: 10.1038/s41586-023-05858-3

Net greenhouse gas balance of fibre wood plantation on peat in Indonesia p.740

doi: 10.1038/s41586-023-05860-9

Clonal haematopoiesis and risk of chronic liver disease p.747

doi: 10.1038/s41586-023-05857-4

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis p.755

doi: 10.1038/s41586-023-05806-1

Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms p.764

doi: 10.1038/s41586-023-05927-7

Dedifferentiation maintains melanocyte stem cells in a dynamic niche p.774

doi: 10.1038/s41586-023-05960-6

Mirusviruses link herpesviruses to giant viruses p.783

doi: 10.1038/s41586-023-05962-4

Lactate regulates cell cycle by remodelling the anaphase promoting complex p.790

doi: 10.1038/s41586-023-05939-3

Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus p.798

doi: 10.1038/s41586-023-05937-5

STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma p.806

doi: 10.1038/s41586-023-05880-5

Ageing-associated changes in transcriptional elongation influence longevity p.814

doi: 10.1038/s41586-023-05922-y

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion p.822

doi: 10.1038/s41586-023-05961-5

mRNA recognition and packaging by the human transcription–export complex p.828

doi: 10.1038/s41586-023-05904-0

Establishment and function of chromatin organization at replication origins p.836

doi: 10.1038/s41586-023-05926-8

The Smc5/6 complex is a DNA loop-extruding motor p.843

doi: 10.1038/s41586-023-05963-3