Global science must not be treated as a diplomatic pawn p.589

Science is being used as leverage in international politics. That must not become a barrier to countries working together on climate change, biodiversity loss, pandemic prevention and other pressing goals.

doi: 10.1038/d41586-022-04477-8

Nuclear-fusion lab achieves ‘ignition’: what does it mean? p.597

doi: 10.1038/d41586-022-04440-7

Fauci responds to Musk’s Twitter attack and rates world’s COVID response p.599

doi: 10.1038/d41586-022-04432-7

How JWST revolutionized astronomy in 2022 p.600

doi: 10.1038/d41586-022-01860-3

JWST’s best images: spectacular stars and spiralling galaxies p.601

Nature’s pick of the sharpest science shots this month is dedicated to the James Webb Space Telescope, which began peering into the Universe earlier this year.

doi: 10.1038/d41586-022-03811-4

NIH plans grant-review overhaul to reduce bias p.602

Reviewers would no longer score researchers’ expertise and institutions during grant evaluations for the US biomedical agency.

doi: 10.1038/d41586-022-04385-x

Why is strep A surging — and how worried are scientists? p.603

doi: 10.1038/d41586-022-04403-y

The best science images of 2022 p.604

An almighty eruption, the cosmos remastered, swirling cells and more.

doi: 10.1038/d41586-022-04372-2

Nature’s 10: ten people who helped shape science in 2022 p.611

doi: 10.1038/d41586-022-04185-3

Gut microbes shape athletic motivation p.633

Microorganisms in the gut produce molecules that activate sensory neurons, stimulating exercise-associated reward circuits in the brain. This newly discovered pathway in mice affects motivation for prolonged exercise.

doi: 10.1038/d41586-022-04355-3

Genetics and anatomy sculpt immune-cell partners of ovarian cancer p.634

The therapeutic options available to treat ovarian cancer need improvement. Data that reveal the cellular, molecular and mutational landscape as such tumours grow and spread might aid efforts to develop new targeted therapies.

doi: 10.1038/d41586-022-04169-3

An energetic look at the life in logged forests p.636

What are the ecological consequences of logging in a tropical forest? A detailed assessment of vegetation growth, bird and mammal numbers, and energy flows in logged and unlogged forests offers some surprising findings.

doi: 10.1038/d41586-022-04356-2

Molecular engineering enables bright blue LEDs p.638

Future LEDs could be based on lead halide perovskites. A breakthrough in preparing device-compatible solids composed of nanoscale perovskite crystals overcomes a long-standing hurdle in making blue perovskite LEDs.

doi: 10.1038/d41586-022-04447-0

A refined use of mutations to guide immunotherapy decisions p.639

Assessment of a tumour’s mutational profile offers a way of predicting a person’s response to anticancer therapies called immune-checkpoint inhibitors. It seems that such approaches might fall short for people who are not of European ancestry.

doi: 10.1038/d41586-022-04448-z

X-rays reveal the magnetic field lighting up a stellar graveyard p.641

An X-ray imaging mission has unveiled the magnetic field in the environment of a dead star. The order and symmetry of the field will reshape our understanding of how it accelerates particles to ultra-high energies.

doi: 10.1038/d41586-022-04445-2

Bats, neuroimaging and the origins of life: a year of remarkable science p.643

Highlights from News & Views published this year.

doi: 10.1038/d41586-022-04429-2

Topological kagome magnets and superconductors p.647

doi: 10.1038/s41586-022-05516-0

Vela pulsar wind nebula X-rays are polarized to near the synchrotron limit p.658

doi: 10.1038/s41586-022-05476-5

Distributed quantum sensing with mode-entangled spin-squeezed atomic states p.661

doi: 10.1038/s41586-022-05363-z

Topological lattices realized in superconducting circuit optomechanics p.666

doi: 10.1038/s41586-022-05367-9

A membrane-based seawater electrolyser for hydrogen generation p.673

doi: 10.1038/s41586-022-05379-5

Synthesis-on-substrate of quantum dot solids p.679

doi: 10.1038/s41586-022-05486-3

Additive manufacturing of micro-architected metals via hydrogel infusion p.685

doi: 10.1038/s41586-022-05433-2

Condensed-phase isomerization through tunnelling gateways p.691

doi: 10.1038/s41586-022-05451-0

Strong cloud–circulation coupling explains weak trade cumulus feedback p.696

doi: 10.1038/s41586-022-05364-y

Global hotspots of salt marsh change and carbon emissions p.701

doi: 10.1038/s41586-022-05355-z

Logged tropical forests have amplified and diverse ecosystem energetics p.707

doi: 10.1038/s41586-022-05523-1

Microbial predators form a new supergroup of eukaryotes p.714

doi: 10.1038/s41586-022-05511-5

Genetic diversity fuels gene discovery for tobacco and alcohol use p.720

doi: 10.1038/s41586-022-05477-4

A male germ-cell-specific ribosome controls male fertility p.725

doi: 10.1038/s41586-022-05508-0

Primate gastrulation and early organogenesis at single-cell resolution p.732

doi: 10.1038/s41586-022-05526-y

A microbiome-dependent gut–brain pathway regulates motivation for exercise p.739

doi: 10.1038/s41586-022-05525-z

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors p.748

doi: 10.1038/s41586-022-05513-3

SARS-CoV-2 infection and persistence in the human body and brain at autopsy p.758

doi: 10.1038/s41586-022-05542-y

Decoupling of respiration rates and abundance in marine prokaryoplankton p.764

doi: 10.1038/s41586-022-05505-3

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides p.771

doi: 10.1038/s41586-022-05501-7

Ovarian cancer mutational processes drive site-specific immune evasion p.778

doi: 10.1038/s41586-022-05496-1

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis p.787

doi: 10.1038/s41586-022-05487-2

Structural insights into the mechanism of the sodium/iodide symporter p.795

doi: 10.1038/s41586-022-05530-2