Do the science on sustainability now p.605

The United Nations Sustainable Development Goals are not a priority for research in high-income countries. That must change.

doi: 10.1038/d41586-022-03389-x

There’s only one choice in Brazil’s election — for the country and the world p.606

A second term for Jair Bolsonaro would represent a threat to science, democracy and the environment.

doi: 10.1038/d41586-022-03388-y

First known map of night sky found hidden in Medieval parchment p.613

Fabled star catalogue by ancient Greek astronomer Hipparchus had been feared lost.

doi: 10.1038/d41586-022-03296-1

First known Neanderthal family discovered in Siberian cave p.615

Ancient DNA from closely related individuals offers fresh insight into Neanderthals’ lives and social structures.

doi: 10.1038/d41586-022-03339-7

Chinese team syncs clocks over record distance using lasers p.616

Physicist Jian-Wei Pan and his colleagues have achieved an important milestone towards redefining the second.

doi: 10.1038/d41586-022-03297-0

Orangutan genome mix-up muddies conservation efforts p.617

Reanalysis of landmark paper finds that eight genome sequences were mistakenly assigned to the wrong orangutans. The impacts on research are as-yet unclear.

doi: 10.1038/d41586-022-03193-7

Renowned Arecibo telescope won’t be rebuilt — and astronomers are heartbroken p.618

The US National Science Foundation has decided to instead open an educational centre at the site.

doi: 10.1038/d41586-022-03293-4

Do soaring energy costs mean we are using less? p.619

Behavioural scientists want to know how much energy people are conserving, and how long new habits will last.

doi: 10.1038/d41586-022-03261-y

Cancer drugs are closing in on some of the deadliest mutations p.620

doi: 10.1038/d41586-022-03392-2

Missing heritability found for height p.631

A combined analysis of 281 genome-wide association studies finds 12,111 common DNA variants associated with a person’s height — and shows that larger studies will not yield more variants in populations of European ancestry.

doi: 10.1038/d41586-022-03029-4

A leap forward in the quest for general catalysts p.632

Truly general chemical reactions work well regardless of the structural features and functional groups in the starting molecule. A new screening protocol speeds up the identification of such reactions in the field of asymmetric catalysis.

doi: 10.1038/d41586-022-03173-x

Global soil map pinpoints key sites for conservation p.634

A map of Earth reveals hotspots of soil biodiversity and regions to target for conservation. Many of these areas are currently unprotected, which suggests that it is time to rethink our soil management and conservation priorities.

doi: 10.1038/d41586-022-03079-8

Mystery find of microbial DNA elements called Borgs p.635

Microorganisms store some genetic information on non-chromosomal elements. The emergence of a surprising version of these elements shifts our understanding of their diversity and potential roles.

doi: 10.1038/d41586-022-02975-3

Early gills exchanged ions before hosting gas transfer p.637

During evolution, key physiological changes enabled vertebrates to achieve a more active lifestyle. A comparison between living animals challenges current ideas on the timing of one such change in our ancestors.

doi: 10.1038/d41586-022-03220-7

How regulatory T cells are primed to aid tolerance of gut bacteria p.638

The immune system must be actively controlled to prevent inflammatory bowel disease. Cell populations have been found that promote immunosuppressive regulatory T cells of the immune system in the gut.

doi: 10.1038/d41586-022-03368-2

An underground route to grasping the Milky Way’s oldest stars p.640

Nuclear-fusion experiments performed deep under Earth’s surface reveal one possible scenario that could have resulted in the chemical abundances found in an ancient star in the Milky Way.

doi: 10.1038/d41586-022-03367-3

The missing risks of climate change p.643

doi: 10.1038/s41586-022-05243-6

General-relativistic precession in a black-hole binary p.652

doi: 10.1038/s41586-022-05212-z

Measurement of ¹⁹F(p, γ)²⁰Ne reaction suggests CNO breakout in first stars p.656

doi: 10.1038/s41586-022-05230-x

Free-space dissemination of time and frequency with 10−19 instability over 113 km p.661

doi: 10.1038/s41586-022-05228-5

The time-programmable frequency comb and its use in quantum-limited ranging p.667

doi: 10.1038/s41586-022-05225-8

Shape memory in self-adapting colloidal crystals p.674

doi: 10.1038/s41586-022-05232-9

Screening for generality in asymmetric catalysis p.680

doi: 10.1038/s41586-022-05263-2

Comprehensive evidence implies a higher social cost of CO₂ p.687

doi: 10.1038/s41586-022-05224-9

Global hotspots for soil nature conservation p.693

doi: 10.1038/s41586-022-05292-x

Ion regulation at gills precedes gas exchange and the origin of vertebrates p.699

doi: 10.1038/s41586-022-05331-7

A saturated map of common genetic variants associated with human height p.704

doi: 10.1038/s41586-022-05275-y

Programmable RNA sensing for cell monitoring and manipulation p.713

doi: 10.1038/s41586-022-05280-1

Gut–brain circuits for fat preference p.722

doi: 10.1038/s41586-022-05266-z

Borgs are giant genetic elements with potential to expand metabolic capacity p.731

doi: 10.1038/s41586-022-05256-1

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation p.737

doi: 10.1038/s41586-022-05089-y

ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut p.744

doi: 10.1038/s41586-022-05141-x

Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota p.752

doi: 10.1038/s41586-022-05309-5

Clathrin-associated AP-1 controls termination of STING signalling p.761

doi: 10.1038/s41586-022-05354-0

HRG-9 homologues regulate haem trafficking from haem-enriched compartments p.768

doi: 10.1038/s41586-022-05347-z

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron p.775

doi: 10.1038/s41586-022-05333-5

Activation of γ-globin expression by hypoxia-inducible factor 1α p.783

doi: 10.1038/s41586-022-05312-w

Structures of α-synuclein filaments from human brains with Lewy pathology p.791

doi: 10.1038/s41586-022-05319-3

Structures of the TMC-1 complex illuminate mechanosensory transduction p.796

doi: 10.1038/s41586-022-05314-8