Deflecting asteroids is not enough — we need to know when they approach p.7

After NASA’s DART asteroid-deflection experiment, a fully funded telescope for detecting space rocks is an equally pressing priority.

doi: 10.1038/d41586-022-03130-8

Laggard rich countries risk slowing the fight against AIDS, malaria and TB p.8

The United Kingdom and Italy need to renew their commitments to banish these major infectious killers from the world.

doi: 10.1038/d41586-022-03129-1

Alzheimer’s drug slows mental decline in trial — but is it a breakthrough? p.15

Researchers are cautiously optimistic following companies’ announcement of positive results for lecanemab.

doi: 10.1038/d41586-022-03081-0

Geneticist who unmasked lives of ancient humans wins medicine Nobel p.16

Svante Pääbo has made stunning discoveries about human evolution using ancient DNA — and his work helped to spawn the competitive field of palaeogenomics.

doi: 10.1038/d41586-022-03086-9

What a new president in Brazil could mean for science p.17

Science-friendly candidate Luiz Inácio Lula da Silva is leading the election polls ahead of current President Jair Bolsonaro.

doi: 10.1038/d41586-022-03071-2

Troubled biodiversity plan gets billion-dollar funding boost p.19

But urgent progress is needed to secure the global deal to save the environment.

doi: 10.1038/d41586-022-03047-2

Japan’s $2-billion initiative to prep pandemic vaccines in 100 days p.20

A new centre will invest in shots for a range of infectious diseases so the country is ready for future outbreaks.

doi: 10.1038/d41586-022-03000-3

Convictions reversed for US chemical engineer accused of hiding China ties p.21

Judge acquits Feng ‘Franklin’ Tao on three of four charges — another blow for the US government’s former China Initiative programme.

doi: 10.1038/d41586-022-03007-w

Last stand in the Amazon p.22

doi: 10.1038/d41586-022-03043-6

Vibrations probe magnetic fields inside evolved stars p.35

Oscillations in the light emanating from three Sun-like stars reveal the presence of strong magnetic fields deep in their interiors. The discovery could explain a quirk of stellar dynamics that has so far eluded understanding.

doi: 10.1038/d41586-022-02979-z

Seasonal peak in Arctic Ocean acidity could shift to the summer p.36

The acidity of the Arctic Ocean currently peaks in winter. A modelling study suggests that this peak could shift to the summer in the future — this is bad news for ecosystem functions, food webs and Indigenous communities.

doi: 10.1038/d41586-022-03076-x

Narrow hiring practices at US universities revealed p.37

An analysis of faculty members employed at academic institutions in the United States reveals that most employees were trained at just a few universities. The finding provides insights into how hiring perpetuates inequalities.

doi: 10.1038/d41586-022-03065-0

Mouse embryo models built from stem cells take shape in a dish p.39

Two groups have grown self-organizing models of mouse embryos from stem cells in vitro. The models mimic mid-gestation embryos, providing an unparalleled opportunity to study early embryonic development.

doi: 10.1038/d41586-022-03075-y

A stable alternative to an explosive synthetic reaction p.40

The ozonolysis reaction is a classic of organic synthesis, but involves the formation of potentially explosive reaction intermediates. A modern, safer spin on this process makes use of previously overlooked chemistry.

doi: 10.1038/d41586-022-02952-w

Magnetic fields of 30 to 100 kG in the cores of red giant stars p.43

doi: 10.1038/s41586-022-05176-0

Discovering faster matrix multiplication algorithms with reinforcement learning p.47

doi: 10.1038/s41586-022-05172-4

Extending the spectrum of fully integrated photonics to submicrometre wavelengths p.54

doi: 10.1038/s41586-022-05119-9

P-type electrical contacts for 2D transition-metal dichalcogenides p.61

doi: 10.1038/s41586-022-05134-w

Compositionally complex doping for zero-strain zero-cobalt layered cathodes p.67

doi: 10.1038/s41586-022-05115-z

Continuous air purification by aqueous interface filtration and absorption p.74

doi: 10.1038/s41586-022-05124-y

Photoexcited nitroarenes for the oxidative cleavage of alkenes p.81

doi: 10.1038/s41586-022-05211-0

Molecular editing of aza-arene C–H bonds by distance, geometry and chirality p.87

doi: 10.1038/s41586-022-05175-1

Arctic Ocean annual high in p_CO2 could shift from winter to summer p.94

doi: 10.1038/s41586-022-05205-y

Invisible ship tracks show large cloud sensitivity to aerosol p.101

doi: 10.1038/s41586-022-05122-0

The origin of placental mammal life histories p.107

doi: 10.1038/s41586-022-05150-w

The Anglo-Saxon migration and the formation of the early English gene pool p.112

doi: 10.1038/s41586-022-05247-2

Quantifying hierarchy and dynamics in US faculty hiring and retention p.120

doi: 10.1038/s41586-022-05222-x

State-dependent pupil dilation rapidly shifts visual feature selectivity p.128

doi: 10.1038/s41586-022-05270-3

Distinguishing externally from saccade-induced motion in visual cortex p.135

doi: 10.1038/s41586-022-05196-w

Embryo model completes gastrulation to neurulation and organogenesis p.143

doi: 10.1038/s41586-022-05246-3

Context-specific emergence and growth of the SARS-CoV-2 Delta variant p.154

doi: 10.1038/s41586-022-05200-3

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8⁺ T cells p.161

doi: 10.1038/s41586-022-05192-0

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program p.173

doi: 10.1038/s41586-022-05257-0

Antibody targeting of E3 ubiquitin ligases for receptor degradation p.182

doi: 10.1038/s41586-022-05235-6

A cellular hierarchy in melanoma uncouples growth and metastasis p.190

doi: 10.1038/s41586-022-05242-7

Biosynthesis of selenium-containing small molecules in diverse microorganisms p.199

doi: 10.1038/s41586-022-05174-2

Visualizing translation dynamics at atomic detail inside a bacterial cell p.205

doi: 10.1038/s41586-022-05255-2

Structure of dynein–dynactin on microtubules shows tandem adaptor binding p.212

doi: 10.1038/s41586-022-05186-y