Liz Truss must value science, not fear it p.219

Populist slogans won’t cut it: the new UK government has nothing to lose and everything to gain by working constructively with scientists and universities.

doi: 10.1038/d41586-022-02819-0

Zero tolerance for threats against scientists p.220

Too often, researchers who share their expertise on contentious topics such as COVID-19 are subjected to abuse. Their institutions must step in to defend and protect them.

doi: 10.1038/d41586-022-02818-1

Webb telescope spots CO2 on exoplanet for first time: what it means for finding alien life p.229

Report heralds what’s to come from the landmark observatory, which is set to explore 76 worlds during its first year.

doi: 10.1038/d41586-022-02350-2

Mouse embryos grown without eggs or sperm: why, and what’s next? p.230

Two research teams grew synthetic embryos using stem cells for long enough to see some organs develop.

doi: 10.1038/d41586-022-02334-2

New Omicron-specific vaccines offer similar protection to existing boosters p.232

Updated COVID jabs have been approved in the United States and United Kingdom, but they offer roughly the same protection as existing vaccines, a study suggests.

doi: 10.1038/d41586-022-02806-5

Wellcome says it has perpetuated ‘systemic racism’ in science p.233

The research funder’s admission has been largely welcomed, but experts say many institutions need to do much more to implement anti-racism pledges.

doi: 10.1038/d41586-022-02299-2

US government reveals big changes to open-access policy p.234

Biden administration instructs all US agencies to require immediate access to federally funded research after it is published, starting in 2026.

doi: 10.1038/d41586-022-02351-1

Pioneering stem-cell trials in Japan report promising early results p.235

The country has invested hundreds of millions of dollars into research on induced pluripotent stem cells to treat diseased organs.

doi: 10.1038/d41586-022-02232-7

What scientists have learnt from COVID lockdowns p.236

doi: 10.1038/d41586-022-02823-4

How nasal-spray vaccines could change the pandemic p.240

doi: 10.1038/d41586-022-02824-3

Microgravity makes fully mobile droplets measurable p.247

Experiments conducted in Earth’s orbit have probed the complicated dynamics of moving droplets by circumventing the size limits imposed by gravity. The findings could lead to improved microchip fabrication techniques.

doi: 10.1038/d41586-022-02342-2

Structural keys unlock RAS–MAPK cellular signalling pathway p.248

Activation of the RAF protein is key to the RAS–MAPK signalling pathway, and involves the SMP protein complex. Structures for SMP shed light on the process, and suggest fresh targets for anticancer drug discovery.

doi: 10.1038/d41586-022-02189-7

How red pigments are produced in fish and fowl p.250

The enzymatic pathway has been characterized for the production of ketocarotenoids: the red pigment in some birds’ feathers and in eye cells that detect red light.

doi: 10.1038/d41586-022-02343-1

Declining crop yields limit the potential of bioenergy p.250

Global-warming projections that rely on bioenergy strategies to offset carbon dioxide emissions could be unduly optimistic, according to a study that accounts for how climate change affects crop yields.

doi: 10.1038/d41586-022-02344-0

A ‘replace me’ signal from dying brown fat fires up weight loss p.252

Brown fat in the body converts energy into heat. The discovery that inosine molecules are released from dying brown fat and induce heat production in nearby brown fat cells could point to a way of combating obesity.

doi: 10.1038/d41586-022-01826-5

Synergistic active sites observed in a solid catalyst p.253

A solid catalyst has been prepared in which pairs of active sites work synergistically to promote an industrial chemical reaction, and the mechanism has been determined — a breakthrough for ‘pair site’ catalysis.

doi: 10.1038/d41586-022-02345-z

Capillary forces generated by biomolecular condensates p.255

doi: 10.1038/s41586-022-05138-6

Rapid quasi-periodic oscillations in the relativistic jet of BL Lacertae p.265

doi: 10.1038/s41586-022-05038-9

A sustained high-temperature fusion plasma regime facilitated by fast ions p.269

doi: 10.1038/s41586-022-05008-1

Imaging hydrodynamic electrons flowing without Landauer–Sharvin resistance p.276

doi: 10.1038/s41586-022-05002-7

Exciton-coupled coherent magnons in a 2D semiconductor p.282

doi: 10.1038/s41586-022-05024-1

Bifunctional hydroformylation on heterogeneous Rh-WOx pair site catalysts p.287

doi: 10.1038/s41586-022-05075-4

Intrinsically unidirectional chemically fuelled rotary molecular motors p.293

doi: 10.1038/s41586-022-05033-0

Delayed use of bioenergy crops might threaten climate and food security p.299

doi: 10.1038/s41586-022-05055-8

Chiral monoterpenes reveal forest emission mechanisms and drought responses p.307

doi: 10.1038/s41586-022-05020-5

Africa’s oldest dinosaurs reveal early suppression of dinosaur distribution p.313

doi: 10.1038/s41586-022-05133-x

A brainstem map for visceral sensations p.320

doi: 10.1038/s41586-022-05139-5

Fos ensembles encode and shape stable spatial maps in the hippocampus p.327

doi: 10.1038/s41586-022-05113-1

Archaic chaperone–usher pili self-secrete into superelastic zigzag springs p.335

doi: 10.1038/s41586-022-05095-0

A microbial supply chain for production of the anti-cancer drug vinblastine p.341

doi: 10.1038/s41586-022-05157-3

LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages p.348

doi: 10.1038/s41586-022-05111-3

MYB orchestrates T cell exhaustion and response to checkpoint inhibition p.354

doi: 10.1038/s41586-022-05105-1

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine p.361

doi: 10.1038/s41586-022-05041-0

Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL p.369

doi: 10.1038/s41586-022-05140-y

Spatial profiling of chromatin accessibility in mouse and human tissues p.375

doi: 10.1038/s41586-022-05094-1

Selective TnsC recruitment enhances the fidelity of RNA-guided transposition p.384

doi: 10.1038/s41586-022-05059-4

In vivo single-molecule analysis reveals COOLAIR RNA structural diversity p.394

doi: 10.1038/s41586-022-05135-9

Structural basis for SHOC2 modulation of RAS signalling p.400

doi: 10.1038/s41586-022-04838-3

Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex p.408

doi: 10.1038/s41586-022-04928-2

Structure of the MRAS–SHOC2–PP1C phosphatase complex p.416

doi: 10.1038/s41586-022-05086-1