Get childhood immunizations back on track after COVID p.7

The effects of the pandemic mean childhood vaccination rates are the lowest for a generation. There is a risk of preventable diseases resurging unless governments treat this as a priority.

doi: 10.1038/d41586-022-02087-y

How AlphaFold can realize AI’s full potential in structural biology p.8

To make the most of artificial intelligence, data and software must be freely shared, and computational, theoretical and experimental researchers must work together closely.

doi: 10.1038/d41586-022-02088-x

‘The entire protein universe’: AI predicts shape of nearly every known protein p.15

DeepMind’s AlphaFold tool has determined the structures of around 200 million proteins.

doi: 10.1038/d41586-022-02083-2

How long is COVID infectious? What scientists know so far p.16

Those with SARS-CoV-2 are often advised to isolate for only a few days. But evidence is mounting that some people can continue to pass on the virus for much longer.

doi: 10.1038/d41586-022-02026-x

Four revelations from the Webb telescope about distant galaxies p.18

Astronomers are rapidly analysing spectacular snapshots of the faraway Universe.

doi: 10.1038/d41586-022-02056-5

Exclusive: Laser-fusion facility heads back to the drawing board p.20

US scientists evaluate their options after failing to replicate record-setting experiment from 2021.

doi: 10.1038/d41586-022-02022-1

Sri Lanka is in crisis — and so are its scientists p.21

doi: 10.1038/d41586-022-01946-y

Hybrid brains: the ethics of transplanting human neurons into animals p.22

doi: 10.1038/d41586-022-02073-4

Heart disease after COVID: what the data say p.26

doi: 10.1038/d41586-022-02074-3

The social connections that shape economic prospects p.37

Data on 21 billion Facebook connections reveal that a new measure of social capital — childhood friendships between people of high and low socio-economic status — is linked to economic mobility later in life.

doi: 10.1038/d41586-022-01843-4

Escort proteins for cellular zinc ions p.38

A metallochaperone protein that ensures that zinc ions are delivered to a crucial cellular enzyme has now been discovered. The finding underscores the subtleties of controlling cellular zinc allocation when the metal is scarce.

doi: 10.1038/d41586-022-01988-2

Nanowire device slips ahead in race to a primary standard for current p.40

A phenomenon known as quantum phase slip has been used to generate a current by moving pairs of electrons through an ultrathin wire. The feat is good news for efforts to pin down the standard unit of current.

doi: 10.1038/d41586-022-01994-4

Risk management alone fails to limit the impact of extreme climate events p.41

An analysis of floods or droughts that hit the same place twice shows that using risk management alone does not reduce the effect of extreme events. Addressing the social drivers of hazard impact, equitably, is essential.

doi: 10.1038/d41586-022-02031-0

Akt protein boosts cancer metabolism through a two-pronged attack p.43

Mutated forms of the protein Akt can be central drivers of cancer metabolism. A mechanism by which Akt promotes synthesis of the metabolic molecule coenzyme A broadens our understanding of the protein’s activity.

doi: 10.1038/d41586-022-01603-4

Quantized current steps due to the a.c. coherent quantum phase-slip effect p.45

doi: 10.1038/s41586-022-04947-z

Non-Hermitian morphing of topological modes p.50

doi: 10.1038/s41586-022-04929-1

Highly efficient blue InGaN nanoscale light-emitting diodes p.56

doi: 10.1038/s41586-022-04933-5

Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing p.62

doi: 10.1038/s41586-022-04914-8

Pulsed hydraulic-pressure-responsive self-cleaning membrane p.69

doi: 10.1038/s41586-022-04942-4

Site-selective, stereocontrolled glycosylation of minimally protected sugars p.74

doi: 10.1038/s41586-022-04958-w

The challenge of unprecedented floods and droughts in risk management p.80

doi: 10.1038/s41586-022-04917-5

Timescales for pluton growth, magma-chamber formation and super-eruptions p.87

doi: 10.1038/s41586-022-04921-9

A male steroid controls female sexual behaviour in the malaria mosquito p.93

doi: 10.1038/s41586-022-04908-6

A time-resolved, multi-symbol molecular recorder via sequential genome editing p.98

doi: 10.1038/s41586-022-04922-8

Social capital I: measurement and associations with economic mobility p.108

doi: 10.1038/s41586-022-04996-4

Social capital II: determinants of economic connectedness p.122

doi: 10.1038/s41586-022-04997-3

Women are credited less in science than men p.135

doi: 10.1038/s41586-022-04966-w

Visual recognition of social signals by a tectothalamic neural circuit p.146

doi: 10.1038/s41586-022-04925-5

Prefrontal feature representations drive memory recall p.153

doi: 10.1038/s41586-022-04936-2

Secreted fungal virulence effector triggers allergic inflammation via TLR4 p.161

doi: 10.1038/s41586-022-05005-4

Akkermansia muciniphila phospholipid induces homeostatic immune responses p.168

doi: 10.1038/s41586-022-04985-7

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy p.174

doi: 10.1038/s41586-022-04817-8

Integrated multi-omic characterization of congenital heart disease p.181

doi: 10.1038/s41586-022-04989-3

PI3K drives the de novo synthesis of coenzyme A from vitamin B5 p.192

doi: 10.1038/s41586-022-04984-8

Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer p.199

doi: 10.1038/s41586-022-04975-9

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila p.209

doi: 10.1038/s41586-022-04960-2

Recording gene expression order in DNA by CRISPR addition of retron barcodes p.217

doi: 10.1038/s41586-022-04994-6