Cash and action are needed to avert a biodiversity crisis p.587

To stop catastrophic losses of animal and plant species, countries need to move ahead with talks and give generously — despite the COVID-19 pandemic.

doi: 10.1038/d41586-022-01430-7

Schools need research to guide the recovery from COVID disruption p.588

Evidence from around the world can help children to catch up, and could improve education as a whole.

doi: 10.1038/d41586-022-01429-0

First pig kidneys transplanted into people: what scientists think p.597

The genetically modified organs seemed to function for more than two days but some researchers are sceptical that the experiments had value.

doi: 10.1038/d41586-022-01418-3

Home testing for syphilis gains support in wake of COVID p.598

With cases of sexually transmitted infections growing, researchers hope self-tests — made popular by the pandemic — could stem the tide.

doi: 10.1038/d41586-022-01363-1

Will the FDA change how it vets drugs following the Alzheimer’s debacle? p.600

The accelerated approval of aducanumab has triggered US lawmakers to push for more oversight from the agency.

doi: 10.1038/d41586-022-01316-8

Flu vaccine could cut COVID risk p.602

Health-care workers who got the influenza vaccine were also protected from COVID-19 — but the effect might not last long.

doi: 10.1038/d41586-022-01315-9

Ancient tooth suggests Denisovans ventured far beyond Siberia p.602

Molar found in Laos could be the first fossil evidence that the hominin species was far-ranging and able to adapt to different climates.

doi: 10.1038/d41586-022-01372-0

Mammoth UK research assessment concludes as leaders eye radical shake up p.603

Funding councils are considering changes to the Research Excellence Framework to improve research culture.

doi: 10.1038/d41586-022-01310-0

How the revamped Large Hadron Collider will hunt for new physics p.604

doi: 10.1038/d41586-022-01388-6

COVID derailed learning for 1.6 billion students. Here’s how schools can help them catch up p.608

doi: 10.1038/d41586-022-01387-7

Maternal enzyme reprograms paternal DNA for healthy offspring p.621

It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are fertilized. This leads to metabolic defects in adult progeny.

doi: 10.1038/d41586-022-01237-6

Sinking diatoms trap silicon in deep seawater of acidified oceans p.622

The seas are acidifying as a result of carbon dioxide emissions. It now emerges that this will alter the solubility of the shells of marine organisms called diatoms — and thereby change the distribution of nutrients and plankton in the ocean.

doi: 10.1038/d41586-022-01365-z

Breakthrough in teleportation furthers quantum network development p.624

Innovations have been developed that facilitate quantum teleportation between nodes in a quantum network that do not neighbour each other, paving the way for complex network configurations.

doi: 10.1038/d41586-022-01364-0

Volatile neurons unite to stabilize visual experience p.625

It has been unclear how the brain creates stable visual experiences from the highly variable activity of individual neurons. Imaging from thousands of neurons across the entire mouse visual cortex provides an explanation.

doi: 10.1038/d41586-022-01212-1

Metabolic diversity drives cancer cell invasion p.627

The migration and growth of cancer cells at sites far from the initial tumour is usually fatal. Metabolic heterogeneity — variable expression of an enzyme in the initial tumour — is identified as an early step in this deadly process.

doi: 10.1038/d41586-022-01301-1

Evolution of Earth’s tectonic carbon conveyor belt p.629

doi: 10.1038/s41586-022-04420-x

Defining the risk of SARS-CoV-2 variants on immune protection p.640

doi: 10.1038/s41586-022-04690-5

In situ recording of Mars soundscape p.653

doi: 10.1038/s41586-022-04679-0

Free-electron lasing with compact beam-driven plasma wakefield accelerator p.659

doi: 10.1038/s41586-022-04589-1

Qubit teleportation between non-neighbouring nodes in a quantum network p.663

doi: 10.1038/s41586-022-04697-y

Realizing repeated quantum error correction in a distance-three surface code p.669

doi: 10.1038/s41586-022-04566-8

Demonstration of fault-tolerant universal quantum gate operations p.675

doi: 10.1038/s41586-022-04721-1

Cilia metasurfaces for electronically programmable microfluidic manipulation p.681

doi: 10.1038/s41586-022-04645-w

Cobalt-electrocatalytic HAT for functionalization of unsaturated C–C bonds p.687

doi: 10.1038/s41586-022-04595-3

Enhanced silica export in a future ocean triggers global diatom decline p.696

doi: 10.1038/s41586-022-04687-0

Hmx gene conservation identifies the origin of vertebrate cranial ganglia p.701

doi: 10.1038/s41586-022-04742-w

Mosquito brains encode unique features of human odour to drive host seeking p.706

doi: 10.1038/s41586-022-04675-4

Emergent reliability in sensory cortical coding and inter-area communication p.713

doi: 10.1038/s41586-022-04724-y

Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning p.722

doi: 10.1038/s41586-022-04711-3

Extricating human tumour immune alterations from tissue inflammation p.728

doi: 10.1038/s41586-022-04718-w

Intracellular lipid surveillance by small G protein geranylgeranylation p.736

doi: 10.1038/s41586-022-04729-7

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs p.741

doi: 10.1038/s41586-022-04685-2

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis p.747

doi: 10.1038/s41586-022-04758-2

Transcriptional coupling of distant regulatory genes in living embryos p.754

doi: 10.1038/s41586-022-04680-7

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency p.761

doi: 10.1038/s41586-022-04756-4

Molecular basis for the initiation of DNA primer synthesis p.767

doi: 10.1038/s41586-022-04695-0