Wanted: better systems for turning evidence into action p.7

The pandemic created a colossal demand for scientific evidence to inform decision-making. Now researchers are mapping out what went wrong and what needs to change.

doi: 10.1038/d41586-022-00559-9

Nature is trialling transparent peer review — the early results are encouraging p.8

Last year, nearly half of Nature authors agreed to publish anonymous referee reports. We hope that more will consider doing so this year.

doi: 10.1038/d41586-022-00493-w

Wuhan market was epicentre of pandemic’s start, studies suggest p.15

Report authors say that the coronavirus SARS-CoV-2 jumped to people from animals sold at the market on two occasions in late 2019 — but some scientists want more definitive evidence.

doi: 10.1038/d41586-022-00584-8

Fossil fish reveal timing of asteroid that killed the dinosaurs p.17

The discovery is likely to reignite controversy over the US site where the fossils were found.

doi: 10.1038/d41586-022-00511-x

A year on Mars: How NASA’s Perseverance hit a geological jackpot p.18

The rover collected exciting rock samples on the first leg of its epic journey. Next, it will turn towards an ancient river delta to look for past life.

doi: 10.1038/d41586-022-00469-w

Asteroids, Hubble rival and Moon base: China sets out space agenda p.19

In the next five years, the nation hopes to launch a robotic craft to an asteroid and two lunar missions.

doi: 10.1038/d41586-022-00439-2

Two scientists will replace disgraced US science adviser Eric Lander p.21

Celebrated sociologist Alondra Nelson and genome leader Francis Collins will temporarily split Lander’s duties.

doi: 10.1038/d41586-022-00484-x

Omicron’s lasting mysteries: four questions scientists are racing to answer p.22

doi: 10.1038/d41586-022-00428-5

Hundreds of COVID trials could provide a deluge of new drugs p.25

doi: 10.1038/d41586-022-00562-0

Mechanism underlying a risk gene in neurodegeneration p.33

Messenger RNA from the gene UNC13A is misprocessed in people who have neurodegenerative diseases known as ALS and FTD. The discovery could explain the disease risk associated with variants in this gene.

doi: 10.1038/d41586-022-00383-1

Plasmas primed for rapid pulse production p.34

A plasma-based device is set to challenge particle accelerators that generate high-quality light pulses, with evidence that the cheaper plasma platform can run at competitive repetition rates.

doi: 10.1038/d41586-022-00544-2

Isotopes tracked on a sub-nanometre scale using electron spectroscopy p.36

Measurements of atomic vibrations can now identify chemical isotopes on a sub-nanometre scale in an electron microscope. An innovative approach makes use of this resolution to build and track isotopic domains.

doi: 10.1038/d41586-022-00545-1

Light-dependent development is tailored in visual neurons p.37

When mouse pups first open their eyes, what they see shapes neuronal connectivity. A study shows that this visual experience has cell-type-specific effects, acting only on a subset of malleable neurons.

doi: 10.1038/d41586-022-00463-2

Lung microbes mediate spinal-cord autoimmunity p.38

Lung bacteria modulate the activity of immune cells in the central nervous system in a rodent model of autoimmunity. This finding might shed light on the neuroinflammation associated with multiple sclerosis.

doi: 10.1038/d41586-022-00468-x

Progress and prospects in magnetic topological materials p.41

doi: 10.1038/s41586-021-04105-x

A persistent ultraviolet outflow from an accreting neutron star binary transient p.52

doi: 10.1038/s41586-021-04324-2

Recovery time of a plasma-wakefield accelerator p.58

doi: 10.1038/s41586-021-04348-8

High-density switchable skyrmion-like polar nanodomains integrated on silicon p.63

doi: 10.1038/s41586-021-04338-w

Imaging of isotope diffusion using atomic-scale vibrational spectroscopy p.68

doi: 10.1038/s41586-022-04405-w

All-perovskite tandem solar cells with improved grain surface passivation p.73

doi: 10.1038/s41586-021-04372-8

Biocatalytic oxidative cross-coupling reactions for biaryl bond formation p.79

doi: 10.1038/s41586-021-04365-7

A wet heterogeneous mantle creates a habitable world in the Hadean p.86

doi: 10.1038/s41586-021-04371-9

The Mesozoic terminated in boreal spring p.91

doi: 10.1038/s41586-022-04446-1

Genetic associations of protein-coding variants in human disease p.95

doi: 10.1038/s41586-022-04394-w

Determinants of emissions pathways in the coupled climate–social system p.103

doi: 10.1038/s41586-022-04423-8

A global timing mechanism regulates cell-type-specific wiring programmes p.112

doi: 10.1038/s41586-022-04418-5

A biophysical account of multiplication by a single neuron p.119

doi: 10.1038/s41586-022-04428-3

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A p.124

doi: 10.1038/s41586-022-04424-7

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A p.131

doi: 10.1038/s41586-022-04436-3

The lung microbiome regulates brain autoimmunity p.138

doi: 10.1038/s41586-022-04427-4

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19 p.145

doi: 10.1038/s41586-022-04421-w

Twin study reveals non-heritable immune perturbations in multiple sclerosis p.152

doi: 10.1038/s41586-022-04419-4

Low-dose metformin targets the lysosomal AMPK pathway through PEN2 p.159

doi: 10.1038/s41586-022-04431-8

Effective drug combinations in breast, colon and pancreatic cancer cells p.166

doi: 10.1038/s41586-022-04437-2

Structure and receptor recognition by the Lassa virus spike complex p.174

doi: 10.1038/s41586-022-04429-2

Structural architecture of the human NALCN channelosome p.180

doi: 10.1038/s41586-021-04313-5