The WHO deserves more money for its core mission — and more respect p.7

After decades of neglect, the World Health Organization needs to be properly funded. The United States is — wrongly — opposing a new funding plan. Other nations shouldn’t wait to adopt it.

doi: 10.1038/d41586-022-00227-y

UK ‘DARPA’ should let the sunshine in p.8

There’s too much secrecy behind ARIA, the United Kingdom’s ambitious planned agency for high-risk, high-reward research funding.

doi: 10.1038/d41586-022-00226-z

China’s zero-COVID strategy: what happens next? p.15

With Omicron or Delta outbreaks already in multiple provinces, scientists say next week’s Winter Olympics will present a major test of China’s zero-tolerance approach.

doi: 10.1038/d41586-022-00191-7

Three, four or more: what’s the magic number for booster shots? p.17

COVID vaccine boosters are proving a useful tool against Omicron, but scientists say that endless boosting might not be a practical or sustainable strategy.

doi: 10.1038/d41586-022-00200-9

Big dog, little dog: mutation explains range of canine sizes p.18

The genetic variant probably comes from ancient wolves.

doi: 10.1038/d41586-022-00209-0

Deltacron: the story of the variant that wasn’t p.19

News of a ‘super variant’ combining Delta and Omicron spread rapidly last week, but researchers say it never existed and the sequences might have resulted from contamination.

doi: 10.1038/d41586-022-00149-9

Will Omicron end the pandemic? Here’s what experts say p.20

The variant’s rapid spread, different vaccine strategies and varying levels of immunity worldwide make the pandemic’s future difficult to model.

doi: 10.1038/d41586-022-00210-7

What the Omicron wave is revealing about human immunity p.22

doi: 10.1038/d41586-022-00214-3

Where did Omicron come from? Three key theories p.26

doi: 10.1038/d41586-022-00215-2

A subset of immune-system T cells branded as seeds for type 1 diabetes p.35

The identification of a specific subpopulation of immune-system T cells that drives type 1 diabetes provides insight into the development of autoimmune disease, and could point the way to new therapies.

doi: 10.1038/d41586-021-03800-z

Lost magnetism pinned on atomic rotations p.36

Crystal-lattice vibrations reveal the mechanism by which laser pulses can strip a metal of its magnetism. The vibrations absorb the angular momentum of electrons in a sample, allowing it to demagnetize.

doi: 10.1038/d41586-022-00189-1

Important genomic regions mutate less often than do other regions p.38

Genomic regions that are crucial for the viability and reproduction of the model plant Arabidopsis thaliana are enriched with molecular features that are associated with a reduced rate of mutation.

doi: 10.1038/d41586-022-00017-6

Search for single magnetic charges in the largest of fields p.39

Collisions between lead ions have produced the largest measured magnetic field in the Universe, enabling a search for elusive exotic particles that carry an isolated magnetic charge.

doi: 10.1038/d41586-022-00188-2

Reproducibility in the fabrication and physics of moiré materials p.41

doi: 10.1038/s41586-021-04173-z

An open science study of ageing in companion dogs p.51

doi: 10.1038/s41586-021-04282-9

Microwave background temperature at a redshift of 6.34 from H2O absorption p.58

doi: 10.1038/s41586-021-04294-5

Search for magnetic monopoles produced via the Schwinger mechanism p.63

doi: 10.1038/s41586-021-04298-1

Domain-wall dynamics in Bose–Einstein condensates with synthetic gauge fields p.68

doi: 10.1038/s41586-021-04250-3

Polarized phonons carry angular momentum in ultrafast demagnetization p.73

doi: 10.1038/s41586-021-04306-4

Selective sulfidation of metal compounds p.78

doi: 10.1038/s41586-021-04321-5

Fluctuation-induced quantum friction in nanoscale water flows p.84

doi: 10.1038/s41586-021-04284-7

Irreversible synthesis of an ultrastrong two-dimensional polymeric material p.91

doi: 10.1038/s41586-021-04296-3

Novel flight style and light wings boost flight performance of tiny beetles p.96

doi: 10.1038/s41586-021-04303-7

Mutation bias reflects natural selection in Arabidopsis thaliana p.101

doi: 10.1038/s41586-021-04269-6

Malaria protection due to sickle haemoglobin depends on parasite genotype p.106

doi: 10.1038/s41586-021-04288-3

Androgens increase excitatory neurogenic potential in human brain organoids p.112

doi: 10.1038/s41586-021-04330-4

A speech planning network for interactive language use p.117

doi: 10.1038/s41586-021-04270-z

Toroidal topology of population activity in grid cells p.123

doi: 10.1038/s41586-021-04268-7

Brahma safeguards canalization of cardiac mesoderm differentiation p.129

doi: 10.1038/s41586-021-04336-y

Emergence of methicillin resistance predates the clinical use of antibiotics p.135

doi: 10.1038/s41586-021-04265-w

Petabase-scale sequence alignment catalyses viral discovery p.142

doi: 10.1038/s41586-021-04332-2

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection p.148

doi: 10.1038/s41586-021-04280-x

An autoimmune stem-like CD8 T cell population drives type 1 diabetes p.156

doi: 10.1038/s41586-021-04248-x

Life histories of myeloproliferative neoplasms inferred from phylogenies p.162

doi: 10.1038/s41586-021-04312-6