Replicating scientific results is tough — but essential p.359

A high-profile replication study in cancer biology has obtained disappointing results. Scientists must redouble their efforts to find out why.

doi: 10.1038/d41586-021-03736-4

Gender balance at Nature Conferences: an update p.360

Nature has made progress in improving the representation and participation of women at scientific conferences — but there is still much more to do.

doi: 10.1038/d41586-021-03735-5

Omicron likely to weaken COVID vaccine protection p.367

Early lab results suggest that existing vaccines could be less effective against the fast-spreading coronavirus variant, but boosters should improve immunity.

doi: 10.1038/d41586-021-03672-3

Half of top cancer studies fail high-profile reproducibility effort p.368

Barriers to reproducing preclinical results included unhelpful author communication, but critics argue that one-time replication attempts don’t tell the whole story.

doi: 10.1038/d41586-021-03691-0

What Sci-Hub’s latest court battle means for research p.370

Delhi court will scrutinize whether the pirate paper website falls foul of India’s copyright law. The verdict could have implications for academic publishers further afield.

doi: 10.1038/d41586-021-03659-0

DeepMind AI tackles one of chemistry’s most valuable techniques p.371

Machine-learning algorithm predicts material properties using electron density.

doi: 10.1038/d41586-021-03697-8

Science misinformation alarms Francis Collins as he leaves top NIH job p.372

doi: 10.1038/d41586-021-03611-2

How the mixed-race mestizo myth warped science in Latin America p.374

doi: 10.1038/d41586-021-03622-z

The race to make vaccines for a dangerous respiratory virus p.379

doi: 10.1038/d41586-021-03704-y

Context is key for learning motor skills p.387

A sophisticated theory for learning motor skills places emphasis on the need for inferring context — drawing conclusions about the structure of the environment — for efficiently storing and expressing motor memories.

doi: 10.1038/d41586-021-03028-x

Hominin footprints at Laetoli reveal a walk on the wild side p.388

Bipedalism is a defining feature of the human lineage, but not all hominin species walked in the same way. New data from a famous palaeoanthropology site reveal that at least two differently bipedal hominins roamed eastern Africa.

doi: 10.1038/d41586-021-03469-4

Human genetic variants identified that affect COVID susceptibility and severity p.390

An individual’s genetics can influence their risk of infection and the severity of disease symptoms. A large international study has identified parts of the human genome that can affect the risk of severe COVID-19.

doi: 10.1038/d41586-021-01773-7

Benefits of megastudies for testing behavioural interventions p.392

Trials of behavioural interventions are hard to compare, hampering policy decision-making. The effects of more than 50 interventions on exercise behaviour have been compared using an experimental design called a megastudy.

doi: 10.1038/d41586-021-03400-x

The emergence, genomic diversity and global spread of SARS-CoV-2 p.408

doi: 10.1038/s41586-021-04188-6

Biogeochemical extremes and compound events in the ocean p.395

doi: 10.1038/s41586-021-03981-7

Sublimation-driven convection in Sputnik Planitia on Pluto p.419

doi: 10.1038/s41586-021-04095-w

Direct limits for scalar field dark matter from a gravitational-wave detector p.424

doi: 10.1038/s41586-021-04031-y

Observation of Feshbach resonances between a single ion and ultracold atoms p.429

doi: 10.1038/s41586-021-04112-y

Detecting spins by their fluorescence with a microwave photon counter p.434

doi: 10.1038/s41586-021-04076-z

Fractional Chern insulators in magic-angle twisted bilayer graphene p.439

doi: 10.1038/s41586-021-04002-3

Tritiation of aryl thianthrenium salts with a molecular palladium catalyst p.444

doi: 10.1038/s41586-021-04007-y

A large West Antarctic Ice Sheet explains early Neogene sea-level amplitude p.450

doi: 10.1038/s41586-021-04148-0

Uncovering global-scale risks from commercial chemicals in air p.456

doi: 10.1038/s41586-021-04134-6

Deep-mantle krypton reveals Earth’s early accretion of carbonaceous matter p.462

doi: 10.1038/s41586-021-04092-z

Footprint evidence of early hominin locomotor diversity at Laetoli, Tanzania p.468

doi: 10.1038/s41586-021-04187-7

Mapping the human genetic architecture of COVID-19 p.472

doi: 10.1038/s41586-021-03767-x

Megastudies improve the impact of applied behavioural science p.478

doi: 10.1038/s41586-021-04128-4

Cognitive control persistently enhances hippocampal information processing p.484

doi: 10.1038/s41586-021-04070-5

Contextual inference underlies the learning of sensorimotor repertoires p.489

doi: 10.1038/s41586-021-04129-3

Exercise plasma boosts memory and dampens brain inflammation via clusterin p.494

doi: 10.1038/s41586-021-04183-x

Combinatorial, additive and dose-dependent drug–microbiome associations p.500

doi: 10.1038/s41586-021-04177-9

Genomic reconstruction of the SARS-CoV-2 epidemic in England p.506

doi: 10.1038/s41586-021-04069-y

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape p.512

doi: 10.1038/s41586-021-04005-0

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination p.517

doi: 10.1038/s41586-021-04060-7

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity p.523

doi: 10.1038/s41586-021-04085-y

Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants p.530

doi: 10.1038/s41586-021-04117-7

A multi-scale map of cell structure fusing protein images and interactions p.536

doi: 10.1038/s41586-021-04115-9

Accuracy mechanism of eukaryotic ribosome translocation p.543

doi: 10.1038/s41586-021-04131-9

De novo protein design by deep network hallucination p.547

doi: 10.1038/s41586-021-04184-w

The conformational cycle of prestin underlies outer-hair cell electromotility p.553

doi: 10.1038/s41586-021-04152-4