COP26 didn’t solve everything — but researchers must stay engaged p.347

The climate summit’s organizers stopped researchers accessing the negotiations in Glasgow, UK. A zero-carbon world needs science and social science to bridge divides.

doi: 10.1038/d41586-021-03433-2

‘COP26 hasn’t solved the problem’: scientists react to UN climate deal p.355

The Glasgow Climate Pact is a step forward, researchers say, but efforts to decarbonize are not enough to limit global temperature rises to 2 °C.

doi: 10.1038/d41586-021-03431-4

Scientist Rebellion: researchers join protesters at COP26 p.357

Scientists are among hundreds of demonstrators at the COP26 climate conference — and want more to join them.

doi: 10.1038/d41586-021-03430-5

COVID antiviral pills: what scientists still want to know p.358

doi: 10.1038/d41586-021-03074-5

How protein-based COVID vaccines could change the pandemic p.359

Jabs from Novavax and other biotech firms are coming. Scientists say they have a lot to offer.

doi: 10.1038/d41586-021-03025-0

Scammers impersonate guest editors to get sham papers published p.361

Hundreds of junk-science papers have been retracted from reputable journals after fraudsters used ‘special issues’ to manipulate the publication process. And the problem is growing.

doi: 10.1038/d41586-021-03035-y

The chase for fusion energy p.362

doi: 10.1038/d41586-021-03401-w

Iodine powers low-cost engines for satellites p.373

Solid iodine transforms directly into gas when heated — a property that has been used to create cheap, compact engines that could make large networks of small satellites commercially viable.

doi: 10.1038/d41586-021-03384-8

GABA molecules made by B cells can dampen antitumour responses p.374

Analysis of immune cells shows that, unexpectedly, B cells secrete GABA, a molecule best known as a neurotransmitter. B-cell-derived GABA can modulate immune responses against tumours, raising the prospect of new therapies.

doi: 10.1038/d41586-021-02953-1

Fifty years of the brain’s sense of space p.376

Neurons in a brain region called the hippocampus were found to be selectively active when rats are in a specific spatial location during natural navigation. The discovery launched research efforts into how the brain supports spatial memory.

doi: 10.1038/d41586-021-03010-7

A mediator of metabolic signals influences puberty and growth p.377

Variants of the melanocortin 3 receptor are associated with delayed puberty and reduced growth, suggesting that this receptor might integrate signals of metabolic status that affect body growth and sexual maturation.

doi: 10.1038/d41586-021-02954-0

Californium—carbon bond captured in a complex p.379

The scarcity and high radioactivity of the heaviest actinide elements, such as californium, make their study a formidable challenge. A landmark report describes the first structural characterization of a californium—carbon bond.

doi: 10.1038/d41586-021-03385-7

Role of bile acids and gut bacteria in healthy ageing of centenarians p.380

A study in humans indicates that certain bile acids that are produced by bacteria and commonly found in people over 100 boost gut health and protect against infection. These findings shed light on the contributors to healthy ageing.

doi: 10.1038/d41586-021-02196-0

Excitons and emergent quantum phenomena in stacked 2D semiconductors p.383

doi: 10.1038/s41586-021-03979-1

Observation of Stark many-body localization without disorder p.393

doi: 10.1038/s41586-021-03988-0

Measuring phonon dispersion at an interface p.399

doi: 10.1038/s41586-021-03971-9

Approaching the intrinsic exciton physics limit in two-dimensional semiconductor diodes p.404

doi: 10.1038/s41586-021-03949-7

In-orbit demonstration of an iodine electric propulsion system p.411

doi: 10.1038/s41586-021-04015-y

Exploding and weeping ceramics p.416

doi: 10.1038/s41586-021-03975-5

Isolation and characterization of a californium metallocene p.421

doi: 10.1038/s41586-021-04027-8

Widespread changes in surface temperature persistence under climate change p.425

doi: 10.1038/s41586-021-03943-z

Cardiopharyngeal deconstruction and ancestral tunicate sessility p.431

doi: 10.1038/s41586-021-04041-w

MC3R links nutritional state to childhood growth and the timing of puberty p.436

doi: 10.1038/s41586-021-04088-9

Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation p.442

doi: 10.1038/s41586-021-03989-z

The orbitofrontal cortex maps future navigational goals p.449

doi: 10.1038/s41586-021-04042-9

Temporal controls over inter-areal cortical projection neuron fate diversity p.453

doi: 10.1038/s41586-021-04048-3

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians p.458

doi: 10.1038/s41586-021-03832-5

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy p.465

doi: 10.1038/s41586-021-04017-w

B cell-derived GABA elicits IL-10⁺ macrophages to limit anti-tumour immunity p.471

doi: 10.1038/s41586-021-04082-1

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs p.477

doi: 10.1038/s41586-021-04061-6

Dietary palmitic acid promotes a prometastatic memory via Schwann cells p.485

doi: 10.1038/s41586-021-04075-0

AKIRIN2 controls the nuclear import of proteasomes in vertebrates p.491

doi: 10.1038/s41586-021-04035-8

Target site selection and remodelling by type V CRISPR-transposon systems p.497

doi: 10.1038/s41586-021-04030-z

Nucleation landscape of biomolecular condensates p.503

doi: 10.1038/s41586-021-03905-5

A synthetic antibiotic class overcoming bacterial multidrug resistance p.507

doi: 10.1038/s41586-021-04045-6

Architecture and assembly mechanism of native glycine receptors p.513

doi: 10.1038/s41586-021-04022-z