Cities must protect people from extreme heat p.331

The North American heatwave highlights the need for urban planners to target extreme heat when designing climate-adaptation strategies.

doi: 10.1038/d41586-021-01903-1

Does the fight against hunger need its own IPCC? p.332

Any plan to create an intergovernmental science panel on food science and policy must protect its independence.

doi: 10.1038/d41586-021-01904-0

Mounting evidence suggests Sputnik COVID vaccine is safe and effective p.339

Russia’s vaccine is in use in nearly 70 nations, but its adoption has been slowed by controversies and questions over rare side effects, and it has yet to garner World Health Organization approval.

doi: 10.1038/d41586-021-01813-2

The COVID pandemic’s lingering impact on clinical trials p.341

Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.

doi: 10.1038/d41586-021-01569-9

COVID vaccines to reach poorest countries in 2023 — despite recent pledges p.342

Amid a COVID surge in Africa, vaccine promises from richer nations are not enough to bring an early end to the pandemic, experts say.

doi: 10.1038/d41586-021-01762-w

Will COVID become a disease of the young? p.343

A growing share of infections among unvaccinated youths in countries with high vaccination rates is putting the spotlight on the role of young people in the pandemic.

doi: 10.1038/d41586-021-01862-7

Mix-and-match COVID vaccines: the case is growing, but questions remain p.344

A slew of studies suggests that mixing vaccines provokes potent immune responses, but scientists still want answers on real-world efficacy and rare side effects.

doi: 10.1038/d41586-021-01805-2

The quest to find genes that drive severe COVID p.346

doi: 10.1038/d41586-021-01827-w

Racism is magnifying the deadly impact of rising city heat p.349

doi: 10.1038/d41586-021-01881-4

Southeast Amazonia is no longer a carbon sink p.354

Atmospheric measurements show that deforestation and rapid local warming have reduced or eliminated the capacity of the eastern Amazonian forest to absorb carbon dioxide — with worrying implications for future global warming.

doi: 10.1038/d41586-021-01871-6

Deciphering metabolism, one microbe at a time p.355

Small molecules produced and modified by gut microorganisms can influence human physiology. An atlas of metabolic outputs of diverse gut microbes offers new ways to decipher the microbial mechanisms behind their production.

doi: 10.1038/d41586-021-01774-6

Measurement-based system provides quantum control of nanoparticles p.357

Precise measurements of the position of a levitating nanosphere have been used to control forces that damp the nanosphere’s motion — potentially opening the way to quantum control of larger objects.

doi: 10.1038/d41586-021-01872-5

A long-term perspective on immunity to COVID p.359

Determining the duration of protective immunity to infection by SARS-CoV-2 is crucial for understanding and predicting the course of the COVID-19 pandemic. Clinical studies now indicate that immunity will be long-lasting.

doi: 10.1038/d41586-021-01557-z

Designing the next generation of proton-exchange membrane fuel cells p.361

doi: 10.1038/s41586-021-03482-7

The 13CO-rich atmosphere of a young accreting super-Jupiter p.370

doi: 10.1038/s41586-021-03616-x

Real-time optimal quantum control of mechanical motion at room temperature p.373

doi: 10.1038/s41586-021-03602-3

Quantum control of a nanoparticle optically levitated in cryogenic free space p.378

doi: 10.1038/s41586-021-03617-w

Exponential suppression of bit or phase errors with cyclic error correction p.383

doi: 10.1038/s41586-021-03588-y

Amazonia as a carbon source linked to deforestation and climate change p.388

doi: 10.1038/s41586-021-03629-6

A lithium-isotope perspective on the evolution of carbon and silicon cycles p.394

doi: 10.1038/s41586-021-03612-1

Pleistocene sediment DNA reveals hominin and faunal turnovers at Denisova Cave p.399

doi: 10.1038/s41586-021-03675-0

Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia p.404

doi: 10.1038/s41586-021-03672-3

Microbiota regulate social behaviour via stress response neurons in the brain p.409

doi: 10.1038/s41586-021-03669-y

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome p.415

doi: 10.1038/s41586-021-03707-9

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans p.421

doi: 10.1038/s41586-021-03647-4

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection p.426

doi: 10.1038/s41586-021-03696-9

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma p.432

doi: 10.1038/s41586-021-03642-9

A transcriptional switch governs fibroblast activation in heart disease p.438

doi: 10.1038/s41586-021-03674-1

Shape of promoter antisense RNAs regulates ligand-induced transcription activation p.444

doi: 10.1038/s41586-021-03589-x

G-protein activation by a metabotropic glutamate receptor p.450

doi: 10.1038/s41586-021-03680-3

Asymmetric activation of the calcium-sensing receptor homodimer p.455

doi: 10.1038/s41586-021-03691-0