Research collaborations bring big rewards: the world needs more p.301

A special issue on COVID-era research collaboration highlights the benefits to science and society of working across borders, cultures and disciplines.

doi: 10.1038/d41586-021-01581-z

COVID has shown the power of science–industry collaboration p.302

But a thriving relationship needs clearer rules around data ownership and intellectual property – and public trust in the process.

doi: 10.1038/d41586-021-01580-0

Landmark Alzheimer’s drug approval confounds research community p.309

Many scientists say there is not enough evidence that Biogen’s aducanumab is an effective therapy for the disease.

doi: 10.1038/d41586-021-01546-2

First science adviser in US president’s cabinet talks COVID, spying and more p.311

doi: 10.1038/d41586-021-01501-1

Does vaccinating adults stop kids from spreading COVID too? p.312

Mass vaccination drives in several countries are providing new data on the extent to which adult vaccination protects children — but the conclusions are mixed.

doi: 10.1038/d41586-021-01549-z

The COVID lab-leak hypothesis: what scientists do and don’t know p.313

doi: 10.1038/d41586-021-01529-3

How the COVID pandemic is changing global science collaborations p.316

doi: 10.1038/d41586-021-01570-2

Forensic database challenged over ethics of DNA holdings p.320

doi: 10.1038/d41586-021-01584-w

Most rivers and streams run dry every year p.335

A model of the world’s rivers and streams has been developed to predict which of these watercourses flow all year round and which go dry. The analysis shows that rivers and streams that run dry are ubiquitous throughout the world.

doi: 10.1038/d41586-021-01528-4

Contact-tracing app curbed the spread of COVID in England and Wales p.336

Digital contact tracing has the potential to limit the spread of COVID-19. A contact-tracing smartphone app that has been readily adopted by people in England and Wales has shown efficacy in reducing disease spread.

doi: 10.1038/d41586-021-01354-8

Glutamate receptor complexes open up and reveal their molecular dialect p.338

AMPA receptors are a class of protein complexes crucial for neuronal communication. Two complementary studies converge on structures of AMPA receptors found in a brain region called the hippocampus.

doi: 10.1038/d41586-021-01380-6

Cancer stem cells in the gut have a bad influence on neighbouring cells p.340

Malignant stem cells in the gut secrete factors that promote the differentiation of neighbouring stem cells, thereby aiding the replacement of normal stem cells by those with cancer-promoting mutations.

doi: 10.1038/d41586-021-01379-z

Attraction and repulsion cooperate during brain-circuit wiring p.341

Examination of the molecular interactions that govern the assembly of neural circuits in a brain region called the hippocampus reveals that neuronal projections are guided to their targets by both attractive and repulsive cues.

doi: 10.1038/d41586-021-01502-0

Great Dimming of Betelgeuse explained p.343

Observations suggest that an unexpected dimming of the massive star Betelgeuse resulted from dust forming over a cold patch in the star’s southern hemisphere. This finding improves our understanding of such massive stars.

doi: 10.1038/d41586-021-01526-6

Peopling of the Americas as inferred from ancient genomics p.356

doi: 10.1038/s41586-021-03499-y

The rise of intelligent matter p.345

doi: 10.1038/s41586-021-03453-y

A dusty veil shading Betelgeuse during its Great Dimming p.365

doi: 10.1038/s41586-021-03546-8

Correlated charge noise and relaxation errors in superconducting qubits p.369

doi: 10.1038/s41586-021-03557-5

Symmetry-enforced topological nodal planes at the Fermi surface of a chiral magnet p.374

doi: 10.1038/s41586-021-03543-x

Double-helical assembly of heterodimeric nanoclusters into supercrystals p.380

doi: 10.1038/s41586-021-03564-6

Localization atomic force microscopy p.385

doi: 10.1038/s41586-021-03551-x

Global prevalence of non-perennial rivers and streams p.391

doi: 10.1038/s41586-021-03565-5

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics p.398

doi: 10.1038/s41586-021-03552-w

Intercalated amygdala clusters orchestrate a switch in fear state p.403

doi: 10.1038/s41586-021-03593-1

The epidemiological impact of the NHS COVID-19 app p.408

doi: 10.1038/s41586-021-03606-z

Thymic development of gut-microbiota-specific T cells p.413

doi: 10.1038/s41586-021-03531-1

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma p.418

doi: 10.1038/s41586-021-03515-1

A phase-separated nuclear GBPL circuit controls immunity in plants p.424

doi: 10.1038/s41586-021-03572-6

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer p.430

doi: 10.1038/s41586-021-03525-z

Apc-mutant cells act as supercompetitors in intestinal tumour initiation p.436

doi: 10.1038/s41586-021-03558-4

Tracing oncogene-driven remodelling of the intestinal stem cell niche p.442

doi: 10.1038/s41586-021-03605-0

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition p.448

doi: 10.1038/s41586-021-03540-0

Gating and modulation of a hetero-octameric AMPA glutamate receptor p.454

doi: 10.1038/s41586-021-03613-0