Africa’s vaccines revolution must have research at its core p.487

It’s an injustice that Africa has to import 99% of its vaccines. COVID has sparked a push for change — and researchers have a crucial role.

doi: 10.1038/d41586-021-01038-3

Three million COVID deaths is a grim milestone p.488

The COVID-19 pandemic has taken too many lives, and has set back efforts to tackle other infectious diseases.

doi: 10.1038/d41586-021-01037-4

COVID vaccines and blood clots: five key questions p.495

doi: 10.1038/d41586-021-00998-w

First monkey–human embryos reignite debate over hybrid animals p.497

The chimaeras lived up to 19 days — but some scientists question the need for such research.

doi: 10.1038/d41586-021-01001-2

Biden pursues giant boost for science spending p.498

US president’s first budget proposal emphasizes applied research and public health, and aims to tackle climate change and racial injustice.

doi: 10.1038/d41586-021-00897-0

India’s COVID-vaccine woes — by the numbers p.500

How an explosion of coronavirus cases in India is putting global vaccine supplies at risk.

doi: 10.1038/d41586-021-00996-y

US universities call for clearer rules on science espionage amid China crackdown p.501

As the National Institutes of Health begins implementing Trump-era guidelines, researchers voice concerns over transparency and racial profiling.

doi: 10.1038/d41586-021-00901-7

How COVID hurt the fight against other dangerous diseases p.502

doi: 10.1038/d41586-021-01022-x

Lipid dismantling of lens organelles for clear vision p.509

In the eye, the transparent lens focuses light on the retina. This transparency is achieved during lens development by a newly identified mechanism — whole organelles are destroyed by the degradation of their lipid membranes.

doi: 10.1038/d41586-021-00888-1

Large-scale origami locks into place under pressure p.510

Inflatable, metre-scale origami structures have been designed to transform from flat structures into expanded forms and then to lock into their new shape. This technology opens the way to the use of large origami structures for engineering.

doi: 10.1038/d41586-021-00971-7

AI uses patient data to optimize selection of eligibility criteria for clinical trials p.512

An artificial-intelligence tool called Trial Pathfinder can run clinical-trial emulations using health-care data from people with cancer, and can learn how to optimize trial-inclusion eligibility criteria, while maintaining patient safety.

doi: 10.1038/d41586-021-00845-y

The future costs of methane emissions p.514

An analysis of the costs of climate change caused by adding one tonne of methane to the atmosphere finds that high-income regions of the world should spend much more on efforts to lower such emissions than should low-income regions.

doi: 10.1038/d41586-021-00972-6

Overshooting tipping point thresholds in a changing climate p.517

Ongoing global warming is likely to cause tipping point thresholds to be passed, but an abrupt system change can still be avoided if the warming is reversed quickly relative to the timescale of the tipping element.

doi: 10.1038/s41586-021-03263-2

The changing landscape of atherosclerosis p.524

doi: 10.1038/s41586-021-03392-8

All-sky dynamical response of the Galactic halo to the Large Magellanic Cloud p.534

The detection of structure in the distribution of giant stars in the outer Galactic halo shows the substantial global impact of the Magellanic clouds on our Galaxy.

doi: 10.1038/s41586-021-03385-7

High-entropy ejecta plumes in Cassiopeia A from neutrino-driven convection p.537

doi: 10.1038/s41586-021-03391-9

A single-molecule van der Waals compass p.541

doi: 10.1038/s41586-021-03429-y

Multistable inflatable origami structures at the metre scale p.545

doi: 10.1038/s41586-021-03407-4

A highly stable and flexible zeolite electrolyte solid-state Li–air battery p.551

doi: 10.1038/s41586-021-03410-9

Near-complete depolymerization of polyesters with nano-dispersed enzymes p.558

doi: 10.1038/s41586-021-03408-3

Equity is more important for the social cost of methane than climate uncertainty p.564

doi: 10.1038/s41586-021-03386-6

High and rising economic costs of biological invasions worldwide p.571

doi: 10.1038/s41586-021-03405-6

Fossoriality and evolutionary development in two Cretaceous mammaliamorphs p.577

doi: 10.1038/s41586-021-03433-2

Genomic insights into population history and biological adaptation in Oceania p.583

doi: 10.1038/s41586-021-03236-5

Shifting attention to accuracy can reduce misinformation online p.590

doi: 10.1038/s41586-021-03344-2

Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome p.596

doi: 10.1038/s41586-021-03369-7

Shared mechanisms underlie the control of working memory and attention p.601

doi: 10.1038/s41586-021-03390-w

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche p.606

doi: 10.1038/s41586-021-03283-y

Type III-A CRISPR immunity promotes mutagenesis of staphylococci p.611

doi: 10.1038/s41586-021-03440-3

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants p.616

doi: 10.1038/s41586-021-03324-6

Quadrivalent influenza nanoparticle vaccines induce broad protection p.623

doi: 10.1038/s41586-021-03365-x

Evaluating eligibility criteria of oncology trials using real-world data and AI p.629

doi: 10.1038/s41586-021-03430-5

Organelle degradation in the lens by PLAAT phospholipases p.634

doi: 10.1038/s41586-021-03439-w

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies p.639

doi: 10.1038/s41586-021-03378-6