Volume 587 Issue 7833



News Features

News & Views

DNA-binding proteins meet their mismatch p.199

Mismatches are alterations in DNA that prevent the bases on each strand of the double helix from aligning correctly. It emerges that mismatches can bend DNA into favourable conformations for binding by proteins.

doi: 10.1038/d41586-020-02658-x

Caspase-8 protein cuts a brake on immune defences p.201

The enzyme caspase-8 can induce cell death or promote survival and the expression of inflammatory proteins. The discovery of a previously unknown caspase-8 target solves one mystery about immune-defence regulation.

doi: 10.1038/d41586-020-02994-y

Primordial element production studied beneath a mountain p.203

Experiments conducted deep beneath a mountain have provided the most precise measurements yet of a key nuclear reaction that occurred seconds after the Big Bang — refining our knowledge of the constituents of the Universe.

doi: 10.1038/d41586-020-03117-3