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Selective killing of antibiotic-resistant bacteria from within p.449

Some bacteria naturally transfer pieces of their DNA within and between species. Such a piece of DNA has been engineered to act as a molecular ‘Trojan horse’ that unleashes a toxin to selectively kill antibiotic-resistant Vibrio cholerae bacteria.

doi: 10.1038/d41586-019-01852-w

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A universal control system for synthetic gene networks p.452

A module for implementing robust feedback control in synthetic cellular networks has been reported. Its design is first proved mathematically to be universal for all networks, and then implemented in living cells.

doi: 10.1038/d41586-019-01772-9

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Microbes make metabolic mischief by targeting drugs p.453

Tests of whether a range of gut bacteria can metabolize a diverse group of drugs has revealed that all the microbes metabolized some drugs and that more than half of the drugs were metabolized.

doi: 10.1038/d41586-019-01851-x

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