Being a PhD student shouldn’t be bad for your health p.307

The first international meeting on postgraduate mental health opens this week, but much more is needed to solve academia’s crisis.

doi: 10.1038/d41586-019-01492-0

Springer Nature journals unify their policy to encourage preprint sharing p.307

doi: 10.1038/d41586-019-01493-z

US environment agency cuts funding for kids’ health studies p.315

The Environmental Protection Agency's decision leaves fate of more than a dozen decades-long projects in doubt.

doi: 10.1038/d41586-019-01491-1

Artificial intelligence is selecting grant reviewers in China p.316

The country's major funding agency says the tool reduces the time it takes to find referees.

doi: 10.1038/d41586-019-01517-8

Intolerance and funding concern Indian scientists ahead of election p.317

Researchers are troubled by a flat budget, and a rise in extremism and pseudoscience.

doi: 10.1038/d41586-019-01465-3

Brazilian biomedical science faces reproducibility test p.318

Researchers at more than 60 Brazilian labs will assess the replicability of research by their country’s scientists.

doi: 10.1038/d41586-019-01485-z

Russia joins in global gene-editing bonanza p.319

A US$1.7-billion programme aims to develop 30 gene-edited plant and animal varieties in the next decade.

doi: 10.1038/d41586-019-01519-6

The trickster microbes that are shaking up the tree of life p.322

doi: 10.1038/d41586-019-01496-w

Chinese investments fuel growth in African science p.325

doi: 10.1038/d41586-019-01398-x

The Moon’s mantle unveiled p.338

doi: 10.1038/d41586-019-01479-x

Scaling up quantum simulations p.339

doi: 10.1038/d41586-019-01483-1

Protein assembles into Archimedean geometry p.340

A natural protein has been engineered to self-associate into an architecture previously unknown among biological molecules: a cage structure based on one of the classic polyhedra identified by Archimedes.

doi: 10.1038/d41586-019-01407-z

A map of β-cell differentiation pathways supports cell therapies for diabetes p.342

The use of stem-cell-derived β-cells to replace those destroyed in pancreatic islets has the potential to cure diabetes. A new analysis provides a deep mechanistic understanding of islet-cell differentiation from stem cells.

doi: 10.1038/d41586-019-01211-9

Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets p.343

Tumours often become resistant to treatment, but how this occurs is poorly understood. An analysis of how the protein Rb affects tumour growth and the response to therapy might cast light on the problem.

doi: 10.1038/d41586-019-01319-y

Transcription factors and 3D genome conformation in cell-fate decisions p.345

doi: 10.1038/s41586-019-1182-7

Self-verifying variational quantum simulation of lattice models p.355

doi: 10.1038/s41586-019-1177-4

The emergent landscape of the mouse gut endoderm at single-cell resolution p.361

doi: 10.1038/s41586-019-1127-1

Charting cellular identity during human in vitro β-cell differentiation p.368

doi: 10.1038/s41586-019-1168-5

A rapidly changing jet orientation in the stellar-mass black-hole system V404 Cygni p.374

doi: 10.1038/s41586-019-1152-0

Chang’E-4 initial spectroscopic identification of lunar far-side mantle-derived materials p.378

doi: 10.1038/s41586-019-1189-0

Temporal and spectral fingerprints of ultrafast all-coherent spin switching p.383

doi: 10.1038/s41586-019-1174-7

Subthreshold firing in Mott nanodevices p.388

doi: 10.1038/s41586-019-1159-6

Atomic rheology of gold nanojunctions p.393

doi: 10.1038/s41586-019-1178-3

Sampling the volatile-rich transition zone beneath Bermuda p.398

doi: 10.1038/s41586-019-1183-6

Climatic controls of decomposition drive the global biogeography of forest-tree symbioses p.404

doi: 10.1038/s41586-019-1128-0

A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau p.409

doi: 10.1038/s41586-019-1139-x

Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics p.413

doi: 10.1038/s41586-019-1166-7

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs p.418

doi: 10.1038/s41586-019-1191-6

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis p.423

doi: 10.1038/s41586-019-1172-9

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy p.428

doi: 10.1038/s41586-019-1162-y

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors p.433

doi: 10.1038/s41586-019-1161-z

An ultra-stable gold-coordinated protein cage displaying reversible assembly p.438

doi: 10.1038/s41586-019-1185-4