Germline gene-editing research needs rules p.145

doi: 10.1038/d41586-019-00788-5

Violence propels Ebola outbreak towards 1,000 cases p.153

Surging conflict in the Democratic Republic of the Congo is hampering efforts to stamp out the virus.

doi: 10.1038/d41586-019-00805-7

Cuba acknowledges climate change threats in its constitution p.155

Move is the latest in a series that the country has made aimed at dealing with stronger hurricanes, more intense droughts and rising sea levels.

doi: 10.1038/d41586-019-00760-3

Geoengineering debate shifts to UN environment assembly p.156

Countries will discuss whether to commission a study of technologies to blunt the effects of climate change.

doi: 10.1038/d41586-019-00717-6

How AI and satellites could help predict volcanic eruptions p.156

Emerging monitoring methods will allow scientists to keep an eye on many more volcanoes.

doi: 10.1038/d41586-019-00752-3

The mouse in the video game p.158

doi: 10.1038/d41586-019-00791-w

How secret conversations inside cells are transforming biology p.162

doi: 10.1038/d41586-019-00792-9

A newly discovered stem cell that keeps bones growing p.178

Bone elongation requires the maintenance of a growth plate of cartilage. Two studies have now identified stem cells specific to this structure that give rise to both cartilage cells and bone-marrow stem cells.

doi: 10.1038/d41586-019-00527-w

Machine learning in quantum spaces p.179

doi: 10.1038/d41586-019-00771-0

Molecular envoys pave the way for pancreatic cancer to invade the liver p.181

Pancreatic cancer usually spreads to the liver. The identification of signals from cells adjacent to pancreatic tumours that boost liver colonization might suggest ways to block this deadly form of cancer invasion.

doi: 10.1038/d41586-019-00710-z

Forty years of fathoming life in hot springs on the ocean floor p.182

Ocean-floor hot springs teeming with animal life were reported 40 years ago. How has knowledge of life thriving in such extreme conditions grown since then, and what challenges remain for exploration and conservation down there?

doi: 10.1038/d41586-019-00728-3

Molecular-decoration technique offers boost to medicinal chemists p.184

doi: 10.1038/d41586-019-00767-w

Battling disease by giving mosquitoes an antimalarial drug p.185

Insecticides that kill mosquitoes have helped to fight malaria, but insecticide resistance is rising. Treating mosquitoes with drugs that target the disease-causing parasite offers another way of tackling malaria.

doi: 10.1038/d41586-019-00648-2

An integrative systems genetic analysis of mammalian lipid metabolism p.187

doi: 10.1038/s41586-019-0984-y

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals p.194

doi: 10.1038/s41586-019-0953-5

A distance to the Large Magellanic Cloud that is precise to one per cent p.200

doi: 10.1038/s41586-019-0999-4

Optical clock comparison for Lorentz symmetry testing p.204

doi: 10.1038/s41586-019-0972-2

Supervised learning with quantum-enhanced feature spaces p.209

doi: 10.1038/s41586-019-0980-2

Electrical resistivity across a nematic quantum critical point p.213

doi: 10.1038/s41586-019-0923-y

Thermodynamic signatures of quantum criticality in cuprate superconductors p.218

doi: 10.1038/s41586-019-0932-x

Site-selective and versatile aromatic C–H functionalization by thianthrenation p.223

doi: 10.1038/s41586-019-0982-0

Self-formed bedrock waterfalls p.229

doi: 10.1038/s41586-019-0991-z

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate p.234

doi: 10.1038/s41586-019-0989-6

Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission p.239

doi: 10.1038/s41586-019-0973-1

S-Geranylgeranyl- L-glutathione is a ligand for human B cell-confinement receptor P2RY8 p.244

doi: 10.1038/s41586-019-1003-z

Hepatocytes direct the formation of a pro-metastatic niche in the liver p.249

doi: 10.1038/s41586-019-1004-y

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis p.253

doi: 10.1038/s41586-019-0996-7

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma p.257

doi: 10.1038/s41586-019-0987-8

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway p.262

doi: 10.1038/s41586-019-1006-9

TRAIP is a master regulator of DNA interstrand crosslink repair p.267

doi: 10.1038/s41586-019-1002-0