Trump’s goal to eradicate the HIV epidemic in the United States is achievable — yet remote p.153

The president’s pledge rings hollow without a major shift in policy and rhetoric.

doi: 10.1038/d41586-019-00557-4

Artificial intelligence alone won’t solve the complexity of Earth sciences p.153

doi: 10.1038/d41586-019-00556-5

Sizzling interest in lab-grown meat belies lack of basic research p.161

‘Clean meat’ firms have drawn tens of millions of dollars in investment in recent years, but technical hurdles remain.

doi: 10.1038/d41586-019-00373-w

Ukraine’s science revolution stumbles five years on p.162

On the anniversary of an uprising that propelled Ukraine away from Russia and towards Europe, scientists say things are improving too slowly.

doi: 10.1038/d41586-019-00512-3

France set to get first national strategy for research p.164

Plan promises funding stability and better career prospects for young researchers, but scientists say significant new investment is crucial.

doi: 10.1038/d41586-019-00484-4

Europe’s next €1-billion science projects: six teams make it to final round p.164

AI enhancement and a virtual time machine are included in the shortlist of pitches.

doi: 10.1038/d41586-019-00541-y

Tropical Africa could be a key to solving methane mystery p.165

Project analyses wetlands’ contribution to a spike in atmospheric concentrations of the potent greenhouse gas.

doi: 10.1038/d41586-019-00457-7

Quake-prone Myanmar leads the way in seismic monitoring p.166

The fledgling democracy is opening up to the world – leading to a transformation in how it monitors earthquakes.

doi: 10.1038/d41586-019-00501-6

Maya bones bring a lost civilization to life p.168

doi: 10.1038/d41586-019-00517-y

Optical cooling achieved by tuning thermal radiation p.186

doi: 10.1038/d41586-019-00526-x

Signalling protein protects the heart muscle from pressure-related stress p.187

If blood flow from the heart is impeded, the pressure created causes tissue dysfunction. It emerges that different signals converge on the TSC2 and mTOR proteins to fine-tune the response of heart cells to stress.

doi: 10.1038/d41586-019-00245-3

One rogue agent suffices for genomic chaos p.188

Genetic instability is a hallmark of cancer cells, and occurs when genes required for genomic maintenance are inactivated. It emerges that altering just one of the two copies of certain genes can drive genetic instability in yeast.

doi: 10.1038/d41586-019-00260-4

Resilient meerkats p.190

How do meerkat populations respond to extreme climatic variations?

doi: 10.1038/d41586-019-00530-1

Host protein mimics viral protein to hinder infection by Ebola virus p.190

Infection by Ebola virus can be fatal. The discovery of a human protein that mimics one type of Ebola protein and binds to another to suppress viral RNA production might aid the development of clinical treatments for the disease.

doi: 10.1038/d41586-019-00182-1

Consistent patterns of nitrogen fixation identified in the ocean p.191

doi: 10.1038/d41586-019-00498-y

Bigger is better in virtual drug screens p.193

A system has been devised that computationally screens hundreds of millions of drug candidates — all of which can be made on demand — against biological targets. This could help to make drug discovery more efficient.

doi: 10.1038/d41586-019-00145-6

Deep learning and process understanding for data-driven Earth system science p.195

doi: 10.1038/s41586-019-0912-1

Convergent estimates of marine nitrogen fixation p.205

doi: 10.1038/s41586-019-0911-2

Discrete attractor dynamics underlies persistent activity in the frontal cortex p.212

doi: 10.1038/s41586-019-0919-7

CasX enzymes comprise a distinct family of RNA-guided genome editors p.218

doi: 10.1038/s41586-019-0908-x

Ultra-large library docking for discovering new chemotypes p.224

doi: 10.1038/s41586-019-0917-9

Observations of fast radio bursts at frequencies down to 400 megahertz p.230

doi: 10.1038/s41586-018-0867-7

A second source of repeating fast radio bursts p.235

doi: 10.1038/s41586-018-0864-x

Near-field photonic cooling through control of the chemical potential of photons p.239

doi: 10.1038/s41586-019-0918-8

Mapping orbital changes upon electron transfer with tunnelling microscopy on insulators p.245

doi: 10.1038/s41586-019-0910-3

Interleukin-22 protects intestinal stem cells against genotoxic stress p.249

doi: 10.1038/s41586-019-0899-7

The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis p.254

doi: 10.1038/s41586-019-0920-1

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling p.259

doi: 10.1038/s41586-019-0928-6

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress p.264

doi: 10.1038/s41586-019-0895-y

Anti-tumour immunity controlled through mRNA m⁶A methylation and YTHDF1 in dendritic cells p.270

doi: 10.1038/s41586-019-0916-x

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution p.275

doi: 10.1038/s41586-019-0887-y

FOXK1 and FOXK2 regulate aerobic glycolysis p.279

doi: 10.1038/s41586-019-0900-5