Nature at 150 p.5

In the 150 years since the first issue was published, Nature has evolved alongside the research community it serves. We hope to continue to grow in the years to come.

doi: 10.1038/d41586-018-07844-6

Japan’s pioneering detector set to join hunt for gravitational waves p.9

LIGO’s Asian cousin will this year deploy ambitious technology to improve sensitivity in the search for these faint, cosmic ripples — but its biggest enemy could be snowmelt.

doi: 10.1038/d41586-018-07867-z

Political upheaval in Nicaragua leaves scientists under siege p.11

Government's response to the protests has led to funding cuts for universities and the firing of faculty members.

doi: 10.1038/d41586-018-07837-5

First hint of near-room-temperature superconductor tantalizes physicists p.12

High-pressure hydrogen materials could be a step towards a new era of superconductivity.

doi: 10.1038/d41586-018-07831-x

What to expect in 2019: science in the new year p.13

Gene-editing, open access and a biosafety rethink are set to shape research.

doi: 10.1038/d41586-018-07847-3

How ‘magic angle’ graphene is stirring up physics p.15

doi: 10.1038/d41586-018-07848-2

Enzymes engineered to trap reaction intermediates p.28

Many enzymatic processes involve a mechanism in which reaction intermediates are covalently attached to the enzyme’s active site. A strategy has been devised that enables mimics of these intermediates to be visualized.

doi: 10.1038/d41586-018-07569-6

All for one and one for all to fight flu p.29

Antibodies have been engineered to recognize diverse strains of influenza, including both the A and B types of virus that cause human epidemics. Are we moving closer to achieving ‘universal’ protection against all flu strains?

doi: 10.1038/d41586-018-07654-w

Methane beneath Greenland’s ice sheet is being released p.31

Methane produced in sediments beneath the Greenland Ice Sheet is released to the atmosphere by meltwater in the summer. This suggests that glacial melt could be an important global source of this greenhouse gas.

doi: 10.1038/d41586-018-07762-7

Topological properties controlled by light p.32

In materials called Weyl semimetals, electrons form structures that have distinct topological properties. The discovery of an ultrafast switch between two of these structures could have many practical applications.

doi: 10.1038/d41586-018-07851-7

Metabolism reprogrammed by the nitric oxide signalling molecule p.33

The signalling molecule nitric oxide protects the kidneys by reprogramming metabolism, and its levels are regulated by a two-component system in mice. These findings identify new targets for drug discovery.

doi: 10.1038/d41586-018-07457-z

Scalable energy-efficient magnetoelectric spin–orbit logic p.35

doi: 10.1038/s41586-018-0770-2

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade p.43

doi: 10.1038/s41586-018-0768-9

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome p.49

doi: 10.1038/s41586-018-0736-4

Direct observation of incommensurate magnetism in Hubbard chains p.56

doi: 10.1038/s41586-018-0778-7

An ultrafast symmetry switch in a Weyl semimetal p.61

doi: 10.1038/s41586-018-0809-4

Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp³ C–H functionalization p.67

doi: 10.1038/s41586-018-0808-5

Greenland melt drives continuous export of methane from the ice-sheet bed p.73

doi: 10.1038/s41586-018-0800-0

Capture of nebular gases during Earth’s accretion is preserved in deep-mantle neon p.78

doi: 10.1038/s41586-018-0771-1

Late Middle Pleistocene Levallois stone-tool technology in southwest China p.82

doi: 10.1038/s41586-018-0710-1

Identifying the pathways required for coping behaviours associated with sustained pain p.86

doi: 10.1038/s41586-018-0793-8

A male-expressed rice embryogenic trigger redirected for asexual propagation through seeds p.91

doi: 10.1038/s41586-018-0785-8

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury p.96

doi: 10.1038/s41586-018-0749-z

Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity p.101

doi: 10.1038/s41586-018-0806-7

Programmable design of orthogonal protein heterodimers p.106

doi: 10.1038/s41586-018-0802-y

Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid p.112

doi: 10.1038/s41586-018-0781-z

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex p.118

doi: 10.1038/s41586-018-0779-6