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Cell parts to complex processes, from the bottom up p.188

Engineering approaches allow biological structures and behaviours to be reconstituted in vitro. A biologist and a physicist discuss the potential and limitations of this bottom-up philosophy in providing insights into complex biological processes.

doi: 10.1038/d41586-018-07246-8

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Cellular stretch reveals superelastic powers p.192

External forces can make cells undergo large, irreversible deformations. It emerges that stretched mammalian cells grown in vitro can enter a state called superelasticity, in which large, reversible deformations occur.

doi: 10.1038/d41586-018-07172-9

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Immune-cell crosstalk in multiple sclerosis p.194

Interactions between the B and T cells of the human immune system are implicated in the brain disease multiple sclerosis. It emerges that B cells make a protein that is also made in the brain, and that T cells recognize this protein.

doi: 10.1038/d41586-018-07063-z

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