Volume 561 Number 7724


The costs of climate inaction p.433

A new analysis breaks down the likely social cost of carbon emissions by country and should make unhappy reading for politicians.

doi: 10.1038/d41586-018-06827-x


News Features

News & Views

Flexible self-powered biosensors p.466

Current biological sensors require bulky external power sources. Ultrathin solar cells have now been fabricated that can power flexible, wearable sensors for the precise and continuous monitoring of biological signals.

doi: 10.1038/d41586-018-06788-1

A core problem in nuclear assembly p.467

Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components.

doi: 10.1038/d41586-018-06668-8

Antibodies pose a double threat to HIV p.468

Drug treatments for HIV infection require the long-term use of daily medication that can have toxic side effects. A pair of HIV-targeting antibodies might offer an alternative therapeutic approach.

doi: 10.1038/d41586-018-06773-8

Complex motion guided without external control p.470

Mechanical structures have been made that exhibit self-guided, multi-step sequences of shape changes in response to an applied force. Such structures could have applications in flexible electronics and soft robotics.

doi: 10.1038/d41586-018-06787-2

Designer proteins activate fluorescent molecules p.471

A computational method has been devised that allows a structural motif found in proteins, known as a β-barrel, to be designed to bind specifically to any small molecule, opening the door to biotechnological applications.

doi: 10.1038/d41586-018-06202-w


Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor p.492

The structure of a complex containing calcitonin gene-related peptide, the human calcitonin gene-related peptide receptor and the Gs heterotrimer, determined using Volta phase-plate cryo-electron microscopy, provides structural insight into the regulation of G-protein-coupled receptors by receptor activity modifying protein 1.

doi: 10.1038/s41586-018-0535-y


A topological source of quantum light p.502

Topologically protected edge states realized in a square array of ring resonators are used to demonstrate a robust source of heralded single photons produced by spontaneous four-wave mixing.

doi: 10.1038/s41586-018-0478-3