The earliest known drawing in history sends a message through 73,000 years p.149
Cross-hatched crayon on a rock shard suggests early humans indulged in abstract art.
doi: 10.1038/d41586-018-06657-x
Volume 561 Issue 7722
리서치 하이라이트
표지 기사： 그람 음성 다중 약재 내성 균주에 대한 새로운 종류의 항생제, 아릴로마이신 유도체 최적화
RANKL 리버스 신호 전달에 의한 뼈 흡수와 생성 작용의 결합
췌장 도관 시스템을 통해서 이동할 수 있는 전암세포 형태의 신생 세포
지구의 보우 쇼크 업스트림에서 고에너지 이온의 효과적인 가속화
반수소에서 1S-2P 리만 알파 전이 관찰
결정성 반강자성 이온 산화물에서의 조절 가능한 원거리 스핀 전송
해수면 상승에 대한 글로벌 해안 습지의 미래 변화 가능성
상처에 저항성을 가진 in vivo 재프로그램화를 통한 상처 내 피부 상피 조직 재생
프로테오믹스 분석을 통해서 밝혀진 지카 바이러스 감염에 관여하는 새로운 숙주 인자
컨텐츠
Editorials
Celebrate the mathematics of Emmy Noether p.149
An algebra pioneer who faced discrimination deserves wider recognition on the centenary of her namesake theorem.
doi: 10.1038/d41586-018-06658-w
Pakistan’s prosperity needs independent experts p.150
Imran Khan’s new administration must respect expertise to meet its ambitious goals.
doi: 10.1038/d41586-018-06659-9
News
Raging wildfires send scientists scrambling to study health effects p.157
Blazes have created natural experiments in Montana and California towns and a monkey-breeding colony.
doi: 10.1038/d41586-018-06123-8
South Africa pushes science to improve daily life p.158
Sweeping policy changes aim to refocus research efforts on poverty, unemployment, drought and other national problems.
doi: 10.1038/d41586-018-06122-9
India’s surprise plan to send people to space by 2022 p.160
But experts say the mission is a huge task and could detract from more useful space programmes.
doi: 10.1038/d41586-018-06146-1
Pulsar discoverer Jocelyn Bell Burnell wins $3-million Breakthrough Prize p.161
Astrophysicist plans to spend prize money — awarded 50 years after the discovery — on increasing diversity in science.
doi: 10.1038/d41586-018-06210-w
Google unveils search engine for open data p.161
The tool, called Google Dataset Search, should help researchers to find the data they need more easily.
doi: 10.1038/d41586-018-06201-x
News Features
How to stop data centres from gobbling up the world’s electricity p.163
The energy-efficiency drive at the information factories that serve us Facebook, Google and Bitcoin.
doi: 10.1038/d41586-018-06610-y
News & Views
Receptor becomes a ligand to control bone remodelling p.180
The protein RANKL is released by bone-forming cells called osteoblasts, and binds to its receptor, RANK, on osteoclast cells to trigger bone removal. It emerges that the pathway can act in reverse to stimulate bone formation.
doi: 10.1038/d41586-018-05960-x
Spins travel far in an antiferromagnet p.181
Controlled long-distance transport of electron spins is required for a kind of electronics known as spintronics. Such transport has been realized in an antiferromagnet, the most common type of magnetic material.
doi: 10.1038/d41586-018-06197-4
A 3D cell shape that enables tube formation p.182
Sheets of cells called epithelia can curve into tubes in embryos. Modelling and in vivo observations reveal that cells in tubes adopt an asymmetric cell shape dubbed scutoid, contrary to some previous assumptions.
doi: 10.1038/d41586-018-06162-1
Future of tidal wetlands depends on coastal management p.183
Computational simulations suggest that future losses of tidal wetlands attributable to sea-level rise could be greatly offset by the landward advance of these ecosystems into newly sea-inundated areas.
doi: 10.1038/d41586-018-06190-x
Elusive mitochondrial connection to inflammation uncovered p.185
PINK1 and parkin proteins help to degrade damaged mitochondrial organelles, and abnormalities in these proteins are linked to Parkinson’s disease. Mouse studies reveal that the proteins act to prevent inflammation.
doi: 10.1038/d41586-018-05988-z
Protein complexes assemble as they are being made p.186
An investigation finds that most protein complexes in yeast cells assemble before the subunits have fully formed. This mechanism might prevent the formation of toxic protein aggregates.
doi: 10.1038/d41586-018-05905-4
Articles
Optimized arylomycins are a new class of Gram-negative antibiotics p.189
Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.
doi: 10.1038/s41586-018-0483-6
Coupling of bone resorption and formation by RANKL reverse signalling p.195
Osteoclasts secrete small extracellular vesicles that stimulate osteoblasts, promoting bone formation via receptor activator of nuclear factor-kappa B ligand (RANKL), thereby linking bone formation and resorption.
doi: 10.1038/s41586-018-0482-7
Precancerous neoplastic cells can move through the pancreatic ductal system p.201
Comparison of multiple lesions from individual pancreases sheds light on how ancestral clones can spread through the ductal system and give rise to precursor lesions, with acquisition of further mutations leading to pancreatic cancer.
doi: 10.1038/s41586-018-0481-8
Letters
Autogenous and efficient acceleration of energetic ions upstream of Earth’s bow shock p.206
Observations of a hot flow anomaly accelerating solar-wind ions suggest a mechanism for such acceleration—a Fermi acceleration trap caused by Earth’s bow shock interacting with the solar wind.
doi: 10.1038/s41586-018-0472-9
Observation of the 1S–2P Lyman-α transition in antihydrogen p.211
The observation of the 1S–2P Lyman-α transition in the antihydrogen atom, the antimatter counterpart of hydrogen, is reported.
doi: 10.1038/s41586-018-0435-1
Hundred-fold enhancement in far-field radiative heat transfer over the blackbody limit p.216
Rates of radiative heat transfer between sub-wavelength planar membranes are experimentally and theoretically shown to exceed the blackbody limit in the far field by more than two orders of magnitude.
doi: 10.1038/s41586-018-0480-9
Tunable long-distance spin transport in a crystalline antiferromagnetic iron oxide p.222
Tunable spin transport over long distances is demonstrated through the antiferromagnetic insulator haematite, paving the way to the development of spin-logic devices based on antiferromagnetic insulators.
doi: 10.1038/s41586-018-0490-7
Three-dimensional printing of hierarchical liquid-crystal-polymer structures p.226
3D printing of liquid-crystal polymers can create lightweight hierarchical structures with very high stiffness and toughness.
doi: 10.1038/s41586-018-0474-7
Future response of global coastal wetlands to sea-level rise p.231
A global modelling approach shows that in response to rises in global sea level, gains of up to 60% in coastal wetland areas are possible, if appropriate coastal management solutions are developed to help support wetland resilience.
doi: 10.1038/s41586-018-0476-5
Stepwise and independent origins of roots among land plants p.235
Meristems of the rooting axes of Asteroxylon mackiei preserved in 407-million-year-old Rhynie chert lack root caps, which demonstrates that the evolution of the root systems of modern vascular plants occurred in a stepwise fashion.
doi: 10.1038/s41586-018-0445-z
Sensing with tools extends somatosensory processing beyond the body p.239
Tools are embodied by the human somatosensory system, serving as sensory extensions of the human body.
doi: 10.1038/s41586-018-0460-0
In vivo reprogramming of wound-resident cells generates skin epithelial tissue p.243
Four transcription factors that specify keratinocyte cell fate, facilitate in vivo reprogramming of wound-resident mesenchymal cells, epithealization and regeneration of skin epithelial tissues in mice.
doi: 10.1038/s41586-018-0477-4
Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling p.248
The plant receptor kinase co-receptor BAK1 contains phosphosites that are required for immune function but not for brassinosteroid-regulated growth in Arabidopsis thaliana; an additional tyrosine phosphosite may be required for the function of many Arabidopsis receptor kinases.
doi: 10.1038/s41586-018-0471-x
An orthogonal proteomic survey uncovers novel Zika virus host factors p.253
Integrative analyses identify host proteins that are modulated by Zika virus at multiple levels and provide a comprehensive framework for the understanding of Zika virus-induced changes to cellular pathways.
doi: 10.1038/s41586-018-0484-5
Parkin and PINK1 mitigate STING-induced inflammation p.258
Acute and chronic mitochondrial stress in mice require PINK1 and parkin to restrain STING-mediated innate immunity.
doi: 10.1038/s41586-018-0448-9
GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis p.263
During starvation, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) targets GTPase-activating proteins to inhibit multiple intracellular transport pathways, thereby promoting energy homeostasis.
doi: 10.1038/s41586-018-0475-6
Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling p.268
Cotranslational assembly is a prevalent mechanism for the formation of oligomeric complexes in Saccharomyces cerevisiae, with one subunit serving as scaffold for the translation of partner subunits.
doi: 10.1038/s41586-018-0462-y
