Volume 560 Issue 7717


Signs of hope emerge against influenza p.141

A universal vaccine might be some way off, but research into how the immune system responds to the virus will be crucial to achieving that goal.

doi: 10.1038/d41586-018-05885-5


News Features

News & Views

Drug candidate and target for leishmaniasis p.171

Better treatments are needed for the neglected tropical disease leishmaniasis. The development of a compound that tackles the disease in mice, and the identification of the protein it targets, offer a way forward.

doi: 10.1038/d41586-018-05765-y

Stable and switchable electric polarization in two dimensions p.174

The electric polarization of materials called ferroelectrics is often suppressed by an internal electric field, limiting uses for these materials. The discovery of a thin-film ferroelectric that is resistant to this field represents a major advance.

doi: 10.1038/d41586-018-05807-5

Newly made mitochondrial DNA drives inflammation p.176

Activation of the inflammasome protein complex in immune cells is a key step that triggers an innate immune response. It emerges that the synthesis and oxidation of mitochondrial DNA drives this activation step.

doi: 10.1038/d41586-018-05764-z


Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease p.185

Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases.

doi: 10.1038/s41586-018-0368-8


Diode fibres for fabric-based optical communications p.214

A scalable thermal drawing process is used to integrate light-emitting and photodetecting diodes into textile-ready polymer fibres, which can be woven into fabrics with possible optical communication and health monitoring applications.

doi: 10.1038/s41586-018-0390-x