How lizards got their big feet p.5
Creatures that survived wild weather in the Caribbean offer a glimpse of natural selection in action.
doi: 10.1038/d41586-018-05821-7
Creatures that survived wild weather in the Caribbean offer a glimpse of natural selection in action.
doi: 10.1038/d41586-018-05821-7
Research has finally generated the tools to attribute heatwaves and downpours to global warming.
doi: 10.1038/d41586-018-05839-x
The lake would be the first body of liquid water ever detected on the red planet, if observations by a European spacecraft are confirmed.
doi: 10.1038/d41586-018-05795-6
Vaccines are mandated for children starting school in China and enjoy widespread public support.
doi: 10.1038/d41586-018-05835-1
Top court’s ruling threatens research on gene-edited crops in the bloc.
doi: 10.1038/d41586-018-05814-6
An observation decades in the making confirms predictions about how light behaves in an immense gravitational field.
doi: 10.1038/d41586-018-05825-3
Policymakers have tried, unsuccessfully, to change this law for decades.
doi: 10.1038/d41586-018-05834-2
Weather forecasters will soon provide instant assessments of global warming’s influence on extreme events.
doi: 10.1038/d41586-018-05849-9
The rate at which carbon dioxide is lost from soil has risen faster than the rate at which it is used by land plants, because soil microbes have become more active — possibly weakening the land surface’s ability to act as a carbon sink.
doi: 10.1038/d41586-018-05842-2
An autoimmune attack on cells that make the hormone insulin causes type 1 diabetes. A mouse study reveals that pancreatic-cell release of insulin peptide fragments into the bloodstream triggers this harmful process.
doi: 10.1038/d41586-018-05710-z
The mystery of where blue diamonds get their colour from has been solved — and reveals a geochemical pathway from Earth’s surface to the lower mantle.
doi: 10.1038/d41586-018-05830-6
Certain cancers are prone to invade the nervous system, which leads to poorer prognosis. A study of leukaemia in mice reveals an unexpectedly direct invasion route from the bone marrow to the central nervous system.
doi: 10.1038/d41586-018-05693-x
At the interface between two facets of an artificial crystal, sound waves can be transmitted in the opposite direction to that expected, and undergo no reflection. Such wave behaviour could have many applications.
doi: 10.1038/d41586-018-05806-6
The molecule succinate, which is a product of metabolism, promotes heat production and therefore calorie burning in brown fat in mice. This discovery could have implications for combating obesity in humans.
doi: 10.1038/d41586-018-05619-7
How genetic and environmental factors contribute to the generation of various subtypes of inhibitory neurons called interneurons in the brain is unclear. A study in mice provides new insight into this process.
doi: 10.1038/d41586-018-05737-2
The application and development of machine-learning methods used in experiments at the frontiers of particle physics (such as the Large Hadron Collider) are reviewed, including recent advances based on deep learning.
doi: 10.1038/s41586-018-0361-2
Analysis of more than 1,500 microbial genomes sheds light on the processing of carbon released as permafrost thaws.
doi: 10.1038/s41586-018-0338-1
Expression of α6 integrin enables acute lymphoblastic leukaemia cells to use neural migratory pathways to invade the central nervous system and metastasize to the brain.
doi: 10.1038/s41586-018-0342-5
Sound waves in a specially designed crystal undergo ‘topologically protected’ negative refraction, whereby no reflection is allowed, at certain facets of the crystal and positive refraction at others.
doi: 10.1038/s41586-018-0367-9
Using topology-switching metal–ligand cages to crosslink polymer networks produces gels whose chemical and mechanical properties can be radically and reversibly switched on irradiation.
doi: 10.1038/s41586-018-0339-0
Direct coupling of aliphatic C–H nucleophiles to aryl electrophiles is described, through the combination of light-driven polyoxometalate hydrogen atom transfer and nickel catalysis.
doi: 10.1038/s41586-018-0366-x
A multiple-proxy reconstruction for the catchment of the Limpopo River and of sea surface temperatures in the Indian Ocean provides evidence for hydroclimatic changes that may have been important in hominin evolution.
doi: 10.1038/s41586-018-0309-6
Global soil respiration is rising, probably in response to environmental changes, suggesting that climate-driven losses of soil carbon are occurring worldwide.
doi: 10.1038/s41586-018-0358-x
Mineral inclusions in blue boron-bearing diamonds reveal that such diamonds are among the deepest diamonds ever found and indicate a viable pathway for the deep-mantle recycling of crustal elements.
doi: 10.1038/s41586-018-0334-5
Two populations of
doi: 10.1038/s41586-018-0352-3
Fish and invertebrate communities transformed across the span of the Great Barrier Reef following the 2016 bleaching event due to a decline in coral-feeding fishes resulting from coral loss, and because of different regional responses of key trophic groups to the direct effect of temperature.
doi: 10.1038/s41586-018-0359-9
Inhibition to the null direction of motion has a critical role in the direction selectivity of neurons in ferret primary visual cortex.
doi: 10.1038/s41586-018-0354-1
A comparative metabolomics approach is used to identify succinate as a key activator of thermogenesis in brown adipose tissue.
doi: 10.1038/s41586-018-0353-2
A sensitive T cell tracking assay reveals immunogenic activity of specific catabolized peptide fragments of insulin and their effects on T cell activity in lymph nodes, highlighting communication between pancreatic islets and lymphoid tissue.
doi: 10.1038/s41586-018-0341-6
53BP1 and shieldin recruit the CTC1–STN1–TEN1 complex and polymerase-α to sites of DNA damage to help control the repair of double-strand breaks.
doi: 10.1038/s41586-018-0324-7
The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1.
doi: 10.1038/s41586-018-0340-7
The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair.
doi: 10.1038/s41586-018-0362-1
High-resolution structures of the human plasma membrane protein patched 1 alone and in complex with the native form of the ligand sonic hedgehog are determined.
doi: 10.1038/s41586-018-0308-7