Pay people to fight malaria p.443
Workers on the front line of the battle against the disease are too often overlooked as scientists and funders plot how to defeat malaria.
doi: 10.1038/d41586-018-05799-2
Volume 559 Issue 7715
리서치 하이라이트
표지 기사： 동남아시아에서의 말라리아 확산을 방지하기 위한 진단 및 약물 내성 기생충 박멸 계획
분자 및 재료 과학 분야에서의 머신 러닝 활용
니오비움-텅스텐 산화물을 이용한 고효율 리튬 이온 베터리 구현
곰팡이 미토콘드리아 칼슘 채널에 대한 냉동-전자 현미경 구조 분석
약 50억년 차이를 둔 태양계 인근 두 종류 별의 생성 히스토리
DNA 오리가미를 템플레이트로 한 복잡한 실리카 컴포지트 나노 물질
흉선 터프트 세포가 촉진하는 IL-4 풍부 수질과 흉선 세포 발달
글루코오스에 의해 조절되는 AMPK에 의한 TET2 인산화에 의한 당뇨병과 암 간의 상관관계
컨텐츠
Editorials
Recognition for inspirational women in science p.443
Awards highlight impressive efforts that reach the next generation.
doi: 10.1038/d41586-018-05801-x
Open data offer risks and rewards for conservation p.444
Scientists have a new tool to help them judge how widely wildlife data should be shared.
doi: 10.1038/d41586-018-05800-y
News
Ecologists try to speed up evolution to save Australian marsupial from toxic toads p.451
The strategy could also be used to bolster the defences of Tasmanian devils and corals on the Great Barrier Reef.
doi: 10.1038/d41586-018-05757-y
Death-defying NASA mission will make humanity’s closest approach to the Sun p.452
The Parker Solar Probe will dive into the sizzling solar corona to explore its mysteries.
doi: 10.1038/d41586-018-05741-6
Philippines sweetens deal for scientists who return home p.453
The government is trying to bolster its research workforce but academics say more needs to be done to improve the sector.
doi: 10.1038/d41586-018-05600-4
Dutch publishing giant cuts off researchers in Germany and Sweden p.454
Negotiations with Elsevier have stalled over open-access deals.
doi: 10.1038/d41586-018-05754-1
Big Bang telescope finale marks end of an era in cosmology p.455
With the end of Europe’s major Planck mission, researchers are moving to smaller projects studying different aspects of the cosmic microwave background.
doi: 10.1038/d41586-018-05788-5
News Features
How to defuse malaria’s ticking time bomb p.458
Scientists are racing to stamp out the disease in southeast Asia before unstoppable strains spread.
doi: 10.1038/d41586-018-05772-z
News & Views
An early hominin arrival in Asia p.480
An excavation has uncovered stone tools in China that are about 2.1 million years old. This evidence pushes back the date of the earliest established signs of a hominin species outside Africa.
doi: 10.1038/d41586-018-05293-9
Quantum optics without photons p.481
Atoms can exhibit wave-like behaviour to form matter waves. Such waves have been used to model the basic processes that underpin how light interacts with matter, providing an experimental platform for future research.
doi: 10.1038/d41586-018-05738-1
Viruses cooperate to defeat bacteria p.482
It emerges that viruses called phages, which infect bacteria, can suppress the bacterial immune system during an initial wave of unsuccessful infection, enabling subsequent viral infection to succeed.
doi: 10.1038/d41586-018-05762-1
Histidine metabolism boosts cancer therapy p.484
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.
doi: 10.1038/d41586-018-05573-4
Neural circuit evolved to process pheromone differently in two species of fruit fly p.485
The males of two closely related species of fly respond differently to a female pheromone. It emerges that this difference is due to alterations in the activity of an evolutionarily conserved neural circuit in the brain.
doi: 10.1038/d41586-018-05595-y
Ancient ice sheet had a growth spurt p.487
An analysis of ancient coral from the Great Barrier Reef reveals that global sea level fell rapidly at the end of the last glacial period. The findings suggest that ice sheets are more dynamic than was previously thought.
doi: 10.1038/d41586-018-05760-3
Review
Machine learning for molecular and materials science p.547
Recent progress in machine learning in the chemical sciences and future directions in this field are discussed.
doi: 10.1038/s41586-018-0337-2
Articles
Niobium tungsten oxides for high-rate lithium-ion energy storage p.556
Micrometre-sized particles of two niobium tungsten oxides have high volumetric capacities and rate performances, enabled by very high lithium-ion diffusion coefficients.
doi: 10.1038/s41586-018-0347-0
Evolution of a central neural circuit underlies Drosophila mate preferences p.564
A female
doi: 10.1038/s41586-018-0322-9
Cryo-EM structure of a fungal mitochondrial calcium uniporter p.570
A cryo-electron microscopy structure of fungal mitochondrial calcium uniporter shows that the channel is tetrameric and sheds light on channel assembly and function.
doi: 10.1038/s41586-018-0333-6
X-ray and cryo-EM structures of the mitochondrial calcium uniporter p.575
X-ray and cryo-electron microscopy structures of fungal mitochondrial calcium uniporter proteins reveal a tetrameric architecture and shed light on the function of the channel.
doi: 10.1038/s41586-018-0330-9
Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters p.580
Structures of the mitochondrial calcium uniporter from fungal and metazoan organisms reveal a tetrameric architecture and shed light on the function of the channel.
doi: 10.1038/s41586-018-0331-8
Letters
The formation of solar-neighbourhood stars in two generations separated by 5 billion years p.585
The two episodes of star formation predicted by the ‘cold flow’ theory of galactic gas accretion also explain the observed bimodality in the chemical-abundance distribution of solar-neighbourhood stars.
doi: 10.1038/s41586-018-0329-2
Spontaneous emission of matter waves from a tunable open quantum system p.589
An open quantum system containing ultracold rubidium atoms trapped in an optical lattice undergoes spontaneous emission of matter waves into free space.
doi: 10.1038/s41586-018-0348-z
Complex silica composite nanomaterials templated with DNA origami p.593
DNA origami is used as a template to produce complex geometric shapes of nanoscale silica hybrid materials.
doi: 10.1038/s41586-018-0332-7
Atmosphere–soil carbon transfer as a function of soil depth p.599
This study of whole-soil carbon dynamics finds that, of the atmospheric carbon that is incorporated into the topmost metre of soil over 50 years, just 19 per cent reaches the subsoil, in a manner that depends on land use and aridity.
doi: 10.1038/s41586-018-0328-3
Rapid glaciation and a two-step sea level plunge into the Last Glacial Maximum p.603
Details of the drops in sea level associated with glaciation during the Last Glacial Maximum are revealed using a coral proxy from the Great Barrier Reef.
doi: 10.1038/s41586-018-0335-4
Hominin occupation of the Chinese Loess Plateau since about 2.1 million years ago p.608
An Early Pleistocene artefact assemblage from the Chinese Loess Plateau indicates that hominins had left Africa by at least 2.1 million years ago, and occupied the Loess Plateau repeatedly for a long time.
doi: 10.1038/s41586-018-0299-4
Triple oxygen isotope evidence for limited mid-Proterozoic primary productivity p.613
Triple oxygen isotope measurements of 1.4-billion-year-old sedimentary sulfates reveal a unique mid-Proterozoic atmosphere and demonstrate that gross primary productivity in the mid-Proterozoic was between 6% and 41% of pre-anthropogenic levels.
doi: 10.1038/s41586-018-0349-y
The outer membrane is an essential load-bearing element in Gram-negative bacteria p.617
The outer membrane of Gram-negative bacteria is shown to be at least as stiff as the cell wall, and this property enables it to protect cells from mechanical pertubations.
doi: 10.1038/s41586-018-0344-3
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells p.622
A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.
doi: 10.1038/s41586-018-0346-1
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development p.627
A comprehensive analysis of the thymic medulla identifies a tuft-cell-like thymic epithelial cell population that is necessary for shaping thymic function.
doi: 10.1038/s41586-018-0345-2
Histidine catabolism is a major determinant of methotrexate sensitivity p.632
Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.
doi: 10.1038/s41586-018-0316-7
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer p.637
Modulation of DNA 5-hydroxymethylcytosine by glucose reveals an AMPK–TET2–5hmC axis that links diabetes to cancer.
doi: 10.1038/s41586-018-0350-5
