With Pruitt gone, Trump and his allies continue to threaten the EPA p.301
Scientists at the US Environmental Protection Agency hope for the best, but fear the worst.
doi: 10.1038/d41586-018-05744-3
Volume 559 Issue 7714
리서치 하이라이트
표지 기사： DNA 기반 승자 독식 전략 신경 네트워크를 이용한 분자 패턴 인식 스캐일 업
8,342개의 mCA로부터 얻어진 클론성 조혈작용에 대한 인사이트
관상 동맥을 형성하는 초기 전구 세포에 대한 단일 세포 레벨 분석
전립선 암을 촉진하는 골수 세포 유래 IL-23 분비
새로운 반응성에 대한 머신-러닝을 이용한 유기 합성 로봇 조절
시신세 기간 동안 일어난 열대지역과 극지역 간의 기온 조절
건강한 성인에서의 급성 골수성 백혈병 발생 위험에 대한 예측 방법 개발
비 바이러스성 지놈 타깃팅을 이용한 T 세포의 기능 및 특이성 재프로그램화
전구 스플라이소솜 구조 분석을 통한 스플라이소솜의 조립 및 조절에 대한 구조적 인사이트
컨텐츠
Editorials
Officials and scientists need help to track down rogue source of CFCs p.302
Emissions of ozone-destroying chemical blamed on Chinese companies, but origin is yet to be confirmed.
doi: 10.1038/d41586-018-05743-4
Track the fate of postdocs to help the next generation of scientists p.302
Data on the career paths of young researchers would help to guide the ‘lost generation’.
doi: 10.1038/d41586-018-05745-2
News
Single subatomic particle illuminates mysterious origins of cosmic rays p.309
When a subatomic particle from space streaked through Antarctica last September, astrophysicists raced to find the source.
doi: 10.1038/d41586-018-05703-y
China expands surveillance of sewage to police illegal drug use p.310
Privacy concerns and cultural differences make some researchers sceptical that the method could work in other countries.
doi: 10.1038/d41586-018-05728-3
Science journals end open-access trial with Gates Foundation p.311
Pilot experiment has seen 26 papers published under open-access terms so far and should yield a report by the end of the year.
doi: 10.1038/d41586-018-05729-2
Jupiter has 10 more moons we didn't know about — and they're weird p.312
The planet now has 79 known moons, including a tiny oddball on a collision course with its neighbours.
doi: 10.1038/d41586-018-05725-6
Gene therapy in mouse fetuses treats deadly disease p.313
The method could minimize damage from disease if a condition is diagnosed in utero.
doi: 10.1038/d41586-018-05726-5
News Features
Science under siege: behind the scenes at Trump’s troubled environment agency p.316
Uncertainty, hostility and irrelevance are now part of daily life for scientists at the US Environmental Protection Agency.
doi: 10.1038/d41586-018-05706-9
News & Views
A record-breaking microscope p.334
An electron microscope has been developed that produces images at higher resolution than conventional approaches can achieve, and is suitable for studying fragile materials that can be damaged by electron beams.
doi: 10.1038/d41586-018-05711-y
Coronary artery development, one cell at a time p.335
An analysis of gene-expression patterns in single cells provides detailed insights into the developmental processes that lead to maturation of the coronary arteries.
doi: 10.1038/d41586-018-05463-9
High-quality genomes reveal new differences between the great apes p.336
High-quality genome sequences for some of the great apes have been assembled using state-of-the-art sequencing tools. The assemblies provide an unbiased comparison between humans and their closest evolutionary relatives.
doi: 10.1038/d41586-018-05679-9
Resistance to prostate-cancer treatment is driven by immune cells p.338
Prostate-cancer treatment usually fails after time as resistance to therapy develops. It emerges from studies of mice and human cells that a population of immune cells can cause this type of treatment resistance.
doi: 10.1038/d41586-018-05460-y
Sluggish Atlantic circulation could cause global temperatures to surge p.340
The circulation system of the North Atlantic Ocean has weakened and is predicted to weaken further in the coming decades. An analysis suggests that this decline could lead to accelerated global surface warming.
doi: 10.1038/d41586-018-05712-x
Speciation far from the madding crowd p.341
New species of marine fishes are found to emerge at a faster rate in high-latitude oceans, which have lower densities of species, than in the species-rich tropics. Are the tropics too crowded for new species to take hold?
doi: 10.1038/d41586-018-05575-2
Articles
Electron ptychography of 2D materials to deep sub-ångström resolution p.343
Combining an electron microscope pixel-array detector that collects the entire distribution of scattered electrons with full-field ptychography greatly improves image resolution and contrast compared to traditional techniques, even at low beam energies.
doi: 10.1038/s41586-018-0298-5
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations p.350
Analysis of genotyping data for more than 150,000 individuals from the UK Biobank using long-range phase information sheds light on mechanisms of clonal haematopoiesis.
doi: 10.1038/s41586-018-0321-x
Single-cell analysis of early progenitor cells that build coronary arteries p.356
During development, new arteries can arise from pre-existing veins; the cell fate switch involved occurs gradually and before the onset of blood flow in mouse embryo hearts.
doi: 10.1038/s41586-018-0288-7
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer p.363
IL-23 produced by myeloid-derived suppressor cells regulates castration resistance in prostate cancer by sustaining androgen receptor signalling.
doi: 10.1038/s41586-018-0266-0
Letters
Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks p.370
DNA-strand-displacement reactions are used to implement a neural network that can distinguish complex and noisy molecular patterns from a set of nine possibilities—an improvement on previous demonstrations that distinguished only four simple patterns.
doi: 10.1038/s41586-018-0289-6
Controlling an organic synthesis robot with machine learning to search for new reactivity p.377
A robot instructed by a machine learning algorithm and coupled with real-time spectroscopic systems provides fast and accurate reaction outcome predictions and reactivity assessments, leading to the discovery of new reactions.
doi: 10.1038/s41586-018-0307-8
Synchronous tropical and polar temperature evolution in the Eocene p.382
A 26-million-year record of equatorial sea surface temperatures reveals synchronous changes of tropical and polar temperatures during the Eocene epoch forced by variations in concentrations of atmospheric carbon dioxide, with a constant degree of polar amplification.
doi: 10.1038/s41586-018-0272-2
Global surface warming enhanced by weak Atlantic overturning circulation p.387
In preindustrial times, a weak Atlantic Meridional Overturning Circulation led to cooling in the Northern Hemisphere, but now it is predicted to cause accelerated global surface warming.
doi: 10.1038/s41586-018-0320-y
An inverse latitudinal gradient in speciation rate for marine fishes p.392
Contrary to previous hypotheses, high-latitude fish lineages form new species at much faster rates than their tropical counterparts especially in geographical regions that are characterized by low surface temperatures and high endemism.
doi: 10.1038/s41586-018-0273-1
Hot streaks in artistic, cultural, and scientific careers p.396
The career trajectories of around 30,000 artists, film directors and scientists show that individuals in each domain have ‘hot streaks’ during which their works have increased impact, despite showing no increase in productivity.
doi: 10.1038/s41586-018-0315-8
Prediction of acute myeloid leukaemia risk in healthy individuals p.400
Individuals who are at high risk of developing acute myeloid leukaemia can be identified years before diagnosis using genetic information from blood samples.
doi: 10.1038/s41586-018-0317-6
Reprogramming human T cell function and specificity with non-viral genome targeting p.405
A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.
doi: 10.1038/s41586-018-0326-5
Mechanism of parkin activation by PINK1 p.410
Structural mass spectrometry of full-length human parkin and a structure of the activated parkin core reveal large-scale domain rearrangements involved in activation of parkin by PINK1.
doi: 10.1038/s41586-018-0224-x
Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action p.415
Fungal genome mining targeted to self-resistance genes close to biosynthetic gene clusters identifies a pathway that produces aspterric acid, which proves to be a potent inhibitor of plant growth.
doi: 10.1038/s41586-018-0319-4
Prespliceosome structure provides insights into spliceosome assembly and regulation p.419
The cryo-electron microscopy structure of the
doi: 10.1038/s41586-018-0323-8
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling p.423
Mass spectrometry-based assays are used to reveal specificity and structural determinants of lipid binding to class A G-protein-coupled receptors, and the effects of specific lipids on receptor coupling to G proteins.
doi: 10.1038/s41586-018-0325-6
