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Actin proteins assemble to protect the genome p.35

The assembly of polymerized actin with motor proteins at DNA breaks in the nucleus supports the mobility and repair of DNA. This finding reveals a layer of regulation that helps to preserve genome integrity.

doi: 10.1038/d41586-018-05339-y

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Key receptor involved in neuronal signalling visualized p.37

Proteins called GABAA receptors have a pivotal role in neuronal inhibition, and are targets of several drugs. Structures of the most abundant GABAA receptor in humans are now reported, and will aid future drug discovery.

doi: 10.1038/d41586-018-05538-7

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General relativity verified by a triple-star system p.40

Einstein’s theory of gravity — the general theory of relativity — is based on the principle that all objects accelerate identically in an external gravitational field. A triple-star system provides a stringent test of this principle.

doi: 10.1038/d41586-018-05549-4

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Unexpected cell population gives fat a brake p.41

Single-cell transcriptional profiling of stem and progenitor cells in fat tissue identifies distinct cell subpopulations, one of which inhibits fat growth by signalling to neighbouring cells.

doi: 10.1038/d41586-018-05120-1

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Taking bioengineered heart valves from faulty to functional p.42

Bioengineered heart valves are a promising treatment for heart-valve disease, but often undergo mechanical failure when implanted. Computational modelling of the initial valve design has now improved their performance in sheep.

doi: 10.1038/d41586-018-05566-3

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Structure of a human synaptic GABAA receptor p.67

The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor.

doi: 10.1038/s41586-018-0255-3

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