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HP1 proteins safeguard embryonic stem cells p.640

A complex that includes the protein HP1 binds to specific regulatory DNA sequences to promote local compaction of genomic regions and inhibit associated genes that drive differentiation of specific cell lineages.

doi: 10.1038/d41586-018-05188-9

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Molecular dynamics simulated by photons p.641

The microscopic behaviour of molecules can be difficult to model using ordinary computers because it is governed by quantum physics. A photonic chip provides a versatile platform for simulating such behaviour.

doi: 10.1038/d41586-018-05245-3

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Spinning on the edge of graphene p.645

Long-sought evidence has been found of magnetism at the edges of graphene, a two-dimensional form of carbon. The findings might enable the development of the logic gates needed for quantum computers.

doi: 10.1038/d41586-018-05240-8

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Synthetic yeast genome reveals its versatility p.647

A redesigned yeast genome is being constructed to allow it to be extensively rearranged on demand. A suite of studies reveals the versatility of the genome-shuffling system, and shows how it could be used for biotechnology applications.

doi: 10.1038/d41586-018-05164-3

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Fifty years since DNA repair was linked to cancer p.648

In 1968, a defect in DNA repair was found to underlie a disorder that makes people extremely sensitive to sunlight. This finding continues to influence research into the origins, diagnosis and treatment of cancer.

doi: 10.1038/d41586-018-05255-1

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Analysis

Emerging trends in global freshwater availability p.651

Analysis of 2002–2016 GRACE satellite observations of terrestrial water storage reveals substantial changes in freshwater resources globally, which are driven by natural and anthropogenic climate variability and human activities.

doi: 10.1038/s41586-018-0123-1

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