Volume 557 Number 7704



News Features

How to save the high seas p.154

As the United Nations prepares a historic treaty to protect the oceans, scientists highlight what’s needed for success.

doi: 10.1038/d41586-018-05079-z

News & Views

From CRISPR scissors to virus sensors p.168

Two bacterial Cas proteins cleave nucleic acids indiscriminately after binding to specific target sequences. This property has now been harnessed to create highly sensitive, portable diagnostic tools for detecting viruses at low cost.

doi: 10.1038/d41586-018-04975-8

Models of Parkinson’s disease revisited p.169

Conventional models propose that activity levels in two neuronal pathways, which have opposing effects on movement, become imbalanced in Parkinson’s disease. Analyses in mice point to a more complex reality.

doi: 10.1038/d41586-018-02589-8

Weak charge of the proton measured p.171

The proton’s weak charge defines the strength of certain interactions between protons and other particles. A precise determination of this quantity provides a stringent test of the standard model of particle physics.

doi: 10.1038/d41586-018-05037-9

Connections that control defence strategy p.172

When presented with a threat, most mice freeze or hide, but a few respond more aggressively. The brain circuits underlying this behavioural choice have now been unpicked.

doi: 10.1038/d41586-018-04747-4



Challenging local realism with human choices p.212

The BIG Bell Test, which used an online video game with 100,000 participants worldwide to provide random bits to 13 quantum physics experiments, contradicts the Einstein–Podolsky–Rosen worldview of local realism.

doi: 10.1038/s41586-018-0085-3

Nanoscale synthesis and affinity ranking p.228

A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.

doi: 10.1038/s41586-018-0056-8