Volume 557 Issue 7703



News Features

After the violence p.19

Peace efforts in Colombia have ended 50 years of intense conflict. Now, scientists are studying former fighters and victims as they attempt to heal.

doi: 10.1038/d41586-018-04976-7

News & Views

Faulty replication can sting p.34

Inappropriate cellular inflammation can cause disease. It emerges that the protein SAMHD1 prevents the release of newly replicated DNA from the nucleus, blocking an undesirable pro-inflammatory response.

doi: 10.1038/d41586-018-02804-6

Helium discovered in the tail of an exoplanet p.35

As the exoplanet WASP-107b orbits its host star, its atmosphere escapes to form a comet-like tail. Helium atoms detected in the escaping gases give astronomers a powerful tool for investigating exoplanetary atmospheres.

doi: 10.1038/d41586-018-04969-6

Evolutionary insights from an ancient bird p.36

Ichthyornis dispar is a key extinct bird species from when birds were shedding characteristics of their dinosaur ancestors and evolving their current features. A reconstructed skull of I. dispar now illuminates this transition.

doi: 10.1038/d41586-018-04780-3

Molecular machines swap rings p.39

A chemical system has been made in which two rings on an axle can switch places by allowing a smaller ring to slip through the cavity of a larger one. The advance opens up potential applications in molecular data storage.

doi: 10.1038/d41586-018-02732-5

Life of a liver awaiting transplantation p.40

People waiting for a liver transplant can die before an organ is found, or, if one is available but of poor quality, there is a risk of transplant failure. A machine that preserves livers might offer a way forward.

doi: 10.1038/d41586-018-04458-w


A randomized trial of normothermic preservation in liver transplantation p.50

Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.

doi: 10.1038/s41586-018-0047-9

Cryo-EM structure of the gasdermin A3 membrane pore p.62

High-resolution cryo-electron microscopy structures of the membrane-pore-forming domain of the mouse gasdermin GSDMA3 show that it forms pores with 26-, 27- or 28-fold symmetry and indicate that it may also form a parallel, soluble, pre-pore ring structure.

doi: 10.1038/s41586-018-0058-6