Time to talk about why so many postgrads have poor mental health p.5

doi: 10.1038/d41586-018-04023-5

Nature: the truth p.5

doi: 10.1038/d41586-018-04024-4

NASA reveals major delay for $8-billion Hubble successor p.11

doi: 10.1038/d41586-018-03863-5

Cancer researchers push to relax rules for clinical trials p.12

doi: 10.1038/d41586-018-03355-6

Beguiling dark-matter signal persists 20 years on p.13

doi: 10.1038/d41586-018-03991-y

EU copyright reforms draw fire from scientists p.14

doi: 10.1038/d41586-018-03837-7

Squeaky clean mice could be ruining research p.16

doi: 10.1038/d41586-018-03916-9

Mississippi rising p.34

doi: 10.1038/d41586-018-03243-z

Forests in flux as climate varies p.35

doi: 10.1038/d41586-018-02858-6

Novel electronic states seen in graphene p.37

doi: 10.1038/d41586-018-02660-4

Two-pore channels open up p.38

doi: 10.1038/d41586-018-02783-8

Bacterial persister cells tackled p.40

doi: 10.1038/d41586-018-03440-w

Observations of the birth of crystals p.41

doi: 10.1038/d41586-018-03801-5

Unconventional superconductivity in magic-angle graphene superlattices p.43

doi: 10.1038/nature26160

The logic of single-cell projections from visual cortex p.51

doi: 10.1038/nature26159

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity p.57

doi: 10.1038/nature26155

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes p.64

doi: 10.1038/nature26158

A density cusp of quiescent X-ray binaries in the central parsec of the Galaxy p.70

doi: 10.1038/nature25029

Quantized Majorana conductance p.74

doi: 10.1038/nature26142

Correlated insulator behaviour at half-filling in magic-angle graphene superlattices p.80

doi: 10.1038/nature26154

Room-temperature nine-µm-wavelength photodetectors and GHz-frequency heterodyne receivers p.85

Room-temperature operation is essential for any optoelectronics technology that aims to provide low-cost, compact systems for widespread applications. A recent technological advance in this direction is bolometric detection for thermal imaging, which has achieved relatively high sensitivity and video rates (about 60 hertz) at room temperature. However, owing to thermally induced dark current, room-temperature operation is still a great challenge for semiconductor photodetectors targeting the wavelength band between 8 and 12 micrometres, and all relevant applications, such as imaging, environmental remote sensing and laser-based free-space communication, have been realized at low temperatures. For these devices, high sensitivity and high speed have never been compatible with high-temperature operation. Here we show that a long-wavelength (nine micrometres) infrared quantum-well photodetector fabricated from a metamaterial made of sub-wavelength metallic resonators exhibits strongly enhanced performance with respect to the state of the art up to room temperature. This occurs because the photonic collection area of each resonator is much larger than its electrical area, thus substantially reducing the dark current of the device. Furthermore, we show that our photonic architecture overcomes intrinsic limitations of the material, such as the drop of the electronic drift velocity with temperature, which constrains conventional geometries at cryogenic operation. Finally, the reduced physical area of the device and its increased responsivity allow us to take advantage of the intrinsic high-frequency response of the quantum detector at room temperature. By mixing the frequencies of two quantum-cascade lasers on the detector, which acts as a heterodyne receiver, we have measured a high-frequency signal, above four gigahertz (GHz). Therefore, these wide-band uncooled detectors could benefit technologies such as high-speed (gigabits per second) multichannel coherent data transfer and high-precision molecular spectroscopy.

doi: 10.1038/nature25790

Molecular nucleation mechanisms and control strategies for crystal polymorph selection p.89

doi: 10.1038/nature25971

Climatic control of Mississippi River flood hazard amplified by river engineering p.95

doi: 10.1038/nature26145

Shifts in tree functional composition amplify the response of forest biomass to climate p.99

doi: 10.1038/nature26152

A new class of synthetic retinoid antibiotics effective against bacterial persisters p.103

doi: 10.1038/nature26157

Whole-organism clone tracing using single-cell sequencing p.108

doi: 10.1038/nature25969

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 p.113

doi: 10.1038/nature25986

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis p.118

doi: 10.1038/nature25985

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis p.122

doi: 10.1038/nature26153

Modular assembly of the nucleolar pre-60S ribosomal subunit p.126

doi: 10.1038/nature26156

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel p.130

doi: 10.1038/nature26139